Biological and Mechanistic Characterization of Novel Prodrugs of Green Tea Polyphenol Epigallocatechin Gallate Analogs in Human Leiomyoma Cell Lines

Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition

(2014) N. Mimura et al.   CANCER RESEARCH

The activity of catechol-O-methyltransferase (COMT) is not impaired by high doses of epigallocatechin-3-gallate (EGCG) in vivo

(2014) Mario Lorenz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Green Tea Extract Inhibition of Human Leiomyoma Cell Proliferation Is Mediated via Catechol-O-Methyltransferase

(2014) Dong Zhang et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Antifibrotic properties of epigallocatechin-3-gallate in endometriosis

(2014) Sachiko Matsuzaki et al.   HUMAN REPRODUCTION

Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference summary and future recommendations

(2014) James H. Segars et al.   HUMAN REPRODUCTION UPDATE

Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: Promising options for prevention and treatment of uterine fibroids?

(2014) Md Soriful Islam et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Synergistic inhibition of lung cancer cell lines by (-)-epigallocatechin-3-gallate in combination with clinically used nitrocatechol inhibitors of catechol-O-methyltransferase

(2013) S. C. Forester et al.   CARCINOGENESIS

Peracetylated (−)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34 + skin stem cells and skin tumors

(2013) Yi-Shiou Chiou et al.   CARCINOGENESIS

Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice

(2012) Chi Chiu Wang et al.   ANGIOGENESIS

2-Methoxyestradiol causes functional repression of transforming growth factor β3 signaling by ameliorating Smad and non-Smad signaling pathways in immortalized uterine fibroid cells

(2012) Salama A. Salama et al.   FERTILITY AND STERILITY

Peracetylated (−)-Epigallocatechin-3-gallate (AcEGCG) Potently Suppresses Dextran Sulfate Sodium-Induced Colitis and Colon Tumorigenesis in Mice

(2012) Yi-Shiou Chiou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cross-Talk between NFkB and the PI3-Kinase/AKT Pathway Can Be Targeted in Primary Effusion Lymphoma (PEL) Cell Lines for Efficient Apoptosis

(2012) Azhar R. Hussain et al.   PLoS One

Activation of AMP-Activated Protein Kinase by 3,3′-Diindolylmethane (DIM) Is Associated with Human Prostate Cancer Cell Death In Vitro and In Vivo

(2012) Di Chen et al.   PLoS One

The estimated annual cost of uterine leiomyomata in the United States

(2011) Eden R. Cardozo et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor

(2011) Glenn S. Van Aller et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells

(2011) S. M. Meeran et al.   Cancer Prevention Research

A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins

(2011) Rosalind J. Miller et al.   EUROPEAN JOURNAL OF NUTRITION

Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo

(2011) Hui Xu et al.   FERTILITY AND STERILITY

The role of the phosphatidylinositol 3-kinase (PI3K) pathway in the development and treatment of uterine cancer

(2011) R. Wendel Naumann   GYNECOLOGIC ONCOLOGY

PI3K-Akt-mTOR and MAPK signaling pathways in polycystic ovarian syndrome, uterine leiomyomas and endometriosis: an update

(2011) Annu Makker et al.   GYNECOLOGICAL ENDOCRINOLOGY

Levels of p27 Sensitize to Dual PI3K/mTOR Inhibition

(2011) M. Lee et al.   MOLECULAR CANCER THERAPEUTICS

Antiangiogenic therapy: impact on invasion, disease progression and metastasis

(2011) John M. L. Ebos et al.   Nature Reviews Clinical Oncology

The chemistry and biotransformation of tea constituents

(2011) Shengmin Sang et al.   PHARMACOLOGICAL RESEARCH

Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice

(2010) Dong Zhang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

(−)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells

(2010) Christine A. Larsen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Targeting Apoptosis Pathway with Natural Terpenoids: Implications for Treatment of Breast and Prostate Cancer

(2010) Huanjie Yang et al.   CURRENT DRUG TARGETS

Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice

(2010) George L. Tipoe et al.   TOXICOLOGY

Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs

(2009) Congde Huo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antiproliferative and proapoptotic effects of epigallocatechin gallate on human leiomyoma cells

(2009) Dong Zhang et al.   FERTILITY AND STERILITY

Green tea polyphenols for prostate cancer chemoprevention: A translational perspective

(2009) J.J. Johnson et al.   PHYTOMEDICINE

Semi-synthesis and proteasome inhibition of D-ring deoxy analogs of (–)-epigallocatechin gallate (EGCG), the active ingredient of green tea extract

(2008) Congde Huo et al.   CANADIAN JOURNAL OF CHEMISTRY

Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model

(2008) H. Xu et al.   HUMAN REPRODUCTION

Effect of a Prodrug of the Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate on the Growth of Androgen-Independent Prostate Cancer In Vivo

(2008) Suk-Ching Lee et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Chemoprevention of fibroid tumors by [−]-epigallocatechin-3-gallate in quail

(2008) Ibrahim H. Ozercan et al.   NUTRITION RESEARCH

Inpatient hysterectomy surveillance in the United States, 2000-2004

(2007) Maura K. Whiteman et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

PI3K/PTEN signaling in tumorigenesis and angiogenesis

(2007) Bing-Hua Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS