Article
Biochemistry & Molecular Biology
Sejin Kim, Hyunjae Lee, Hanbyeol Moon, Ran Kim, Minsuk Kim, Seongtae Jeong, Hojin Kim, Sang Hyeon Kim, Soo Seok Hwang, Min Young Lee, Jongmin Kim, Byeong-Wook Song, Woochul Chang
Summary: Cardiac tissue damage following ischemia leads to cardiomyocyte apoptosis and myocardial fibrosis. The active polyphenol flavonoid or catechin epigallocatechin-3-gallate (EGCG) protects ischemic myocardium and is involved in the regulation of endothelial-to-mesenchymal transition (EndMT). In this study, EGCG treatment was shown to regenerate ischemic tissue and induce cardioprotection by regulating proteins associated with the EndMT process, as well as positively regulating cardiomyocyte apoptosis and fibrosis.
Article
Medicine, Research & Experimental
Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi
Summary: This study found that EGCG can prevent the occurrence of hepatic fibrosis by suppressing oxidative stress and reducing OPN expression. Treatment with EGCG significantly alleviated liver injury and fibrogenesis, and reduced collagen deposition in liver tissue.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Baogui Liu, Zhiyin Chen, Yangling Zhang, Enshuo Liu, Shuming Han, Zhihua Gong, Wenjun Xiao
Summary: The study improved the bioavailability and efficacy of EGCG by preparing EGCG+LTA/βCD inclusion complexes, which significantly enhanced its lipid-lowering and weight loss effects by improving gut microflora and EGCG bioavailability.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Chemistry, Applied
Jianyong Zhang, Hongchun Cui, Jiahuan Qiu, Xiaoqing Wang, Yixin Zhong, Caiping Yao, Lanying Yao, Qunxiong Zheng, ChunHua Xiong
Summary: This study aimed to improve the stability and bioavailability of EGCG in aqueous solutions and in vivo by preparing EGCG glycosylated arachin nanoparticles and EGCG glycosylated casein nanoparticles. The results showed that the DPPH scavenging activity of the nanoparticles was stable within temperature range of 25-70 degrees Celsius. EGCG enhanced the crosslinking effect of molecular particles in the glycosylation complexes solution. The glycosylated protein nanoparticles were stable to acid-base and enzymolysis in simulated gastrointestinal fluid.
Article
Agriculture, Multidisciplinary
Lijie Jia, Fuming Wang, Ke Zhang, Dongxu Wang, Xiaoxiao Wang, Xiuli Li, Jinsong Zhang
Summary: The study found that L-theanine in tea can inhibit the oxidation of tea catechins by chelating copper, thereby protecting the liver from damage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Honghui Zhang, Wei Su, Rusong Zhao, Mei Li, Shigang Zhao, Zi-Jiang Chen, Han Zhao
Summary: This study delves into the precise impact and underlying mechanisms of EGCG on aged oocytes. Both in vitro and in vivo experiments demonstrate EGCG's capacity to enhance the quality of aged oocytes. In vitro application of EGCG yields remarkable improvements, including heightened rates of first polar body extrusion, refined spindle morphology, enhanced mitochondrial function, and reduced oxidative stress. Besides, EGCG may enhance Arf6 expression through direct interaction in aged oocytes, consequently promoting the assembly of spindle-associated F-actin and mitigating the aneuploidy induced by the disruption of spindle F-actin. In addition, these positive outcomes are corroborated by enhanced fertility observed in aged mice, providing a therapeutic intervention to address fertility challenges associated with advanced age.
CELL PROLIFERATION
(2023)
Article
Plant Sciences
Qianjin Xie, Xiaqiang Cai, Xu Dong, Ying Wang, Minghui Sun, Lingling Tai, Yan Xu
Summary: The combination of EGCG with Vc and glycerol could effectively increase its stability and uric acid-lowering activity, which sheds light on the development and application of EGCG in the fields of food and medicine.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Tomonori Unno, Yoshiharu Araki, Shun Inagaki, Makoto Kobayashi, Masaki Ichitani, Takanobu Takihara, Hitoshi Kinugasa
Summary: Dietary fructooligosaccharides (FOS) were found to increase the plasma concentration of EGCG in rats by preventing its auto-oxidation. Treatment with FOS resulted in a dose-dependent increase in cecal lactate levels and alterations in the abundance of Lactobacillus and Collinsella. Consequently, FOS contributed to the protection of EGCG from auto-oxidation and allowed it to be absorbed into the blood circulation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Qiang Jia, Rui Yang, Shomaila Mehmood, Yan Li
Summary: This study investigated the anti-fibrotic effects of epigallocatechin-3-gallate (EGCG) on diabetic-induced myocardial fibrosis and its underlying molecular mechanisms. The results showed that EGCG treatment improved cardiac contractile function, attenuated myocardial hypertrophy and injury, activated myocardial autophagy, and alleviated myocardial fibrosis in type 2 diabetic rats.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Yingjie Wang, Shanqiu Jian, Wen Li, Ling Zhao, Gang Ye, Fei Shi, Lixia Li, Yuanfeng Zou, Xu Song, Xinghong Zhao, Zhongqiong Yin, Yinglun Li, Huaqiao Tang
Summary: This study evaluated the protective effect of epigallocatechin gallate (EGCG) on liver damage secondary to P. aeruginosa infection. The results showed that EGCG reduced liver function markers, improved histopathological changes, reduced oxidative stress and inhibited inflammation response. EGCG exerted its liver protective effect through regulation of multiple signaling pathways, providing a new therapeutic strategy for P. aeruginosa infection-related liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Engineering, Environmental
Yuan Cheng, Xin Li, Ming-Ya Fang, Qing-Jing Ye, Zhi-Miao Li, Golam Jalal Ahammed
Summary: The application of EECCG alleviated the adverse effects of cadmium stress in tomato plants by reducing oxidative stress and promoting the expression of RBOH1 gene. These findings contribute to our understanding of the stress resistance properties of EGCG in plants.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Oncology
Chunguang Wang, Meiling Bai, Zhiguang Sun, Nan Yao, Aiting Zhang, Shengyu Guo, Zatollah Asemi
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that affect gene expression and are inappropriately expressed in various cancers. Recent research shows that phytochemicals like EGCG can modulate miRNAs and have potential anticancer effects. Targeting specific miRNAs with EGCG can regulate cancer-related processes and improve current cancer treatments.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Jaganmay Sarkar, Manjusri Das, Md Sariful Islam Howlader, Prateeksha Prateeksha, Derek Barthels, Hiranmoy Das
Summary: EGCG inhibits osteoclast differentiation through modulating mitophagy and ROCK-mediated pathways. This study provides important theoretical support for the development of new therapies for arthritis.
CELL DEATH & DISEASE
(2022)