Review
Pharmacology & Pharmacy
Joel Brunner, Sakthikumar Ragupathy, Gerrit Borchard
Summary: Research focuses on modulating intercellular tight junctions to enhance drug absorption and bioavailability, with challenges in commercialization. Target-specific permeation enhancers have potential clinical applications.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Food Science & Technology
Yunika Mayangsari, Mayu Okudaira, Chinatsu Mano, Yuki Tanaka, Osamu Ueda, Tomohiro Sakuta, Yoshiharu Suzuki, Yoshinari Yamamoto, Takuya Suzuki
Summary: Research showed that DMF can enhance intestinal TJ barrier integrity by increasing the expression of occludin and claudin-1, while reducing the expression of claudin-2. This regulation involves the induction of occludin protein translation via mTOR and silencing Cldn2 mRNA via miR-16-5p.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Gastroenterology & Hepatology
Roberta Lais Mendonca de Mattos, Danilo Toshio Kanno, Fabio Guilherme Campos, Geovanna Pacciulli Pereira, Mateus Magami Yoshitani, Andress de Godoy Delben, Jose Aires Pereira, Carlos Augusto Real Martinez
Summary: The study found that the content of claudin-3 and occludin in the cell membranes of neoplastic tissue in patients with colorectal cancer is reduced.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Agriculture, Dairy & Animal Science
Sung Woo Kim, Yu-Da Jeong, Ga-Yeong Lee, Jinwook Lee, Jae-Yeung Lee, Chan-Lan Kim, Yeoung-Gyu Ko, Sung-Soo Lee, Bongki Kim
Summary: The blood-epididymis barrier (BEB) is a crucial microenvironment for the maturation, protection, transport, and storage of spermatozoa in the epididymis. In this study, the expression and localization of tight junction (TJ) proteins in the goat epididymis were investigated. It was found that at least five TJ proteins, including ZO-1, ZO-2, ZO-3, occludin, and Cldn3, were present in TJs and exhibited age-dependent expression patterns. These findings suggest that the distinct expression patterns of TJ proteins are essential for the regulation of luminal contents and the maintenance of adequate luminal conditions in the goat epididymis, which are necessary for spermatozoa maturation, protection, transport, and storage.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abigail Taylor, Mark Warner, Christopher Mendoza, Calvin Memmott, Tom LeCheminant, Sara Bailey, Colter Christensen, Julie Keller, Arminda Suli, Dario Mizrachi
Summary: The tight junction (TJ) is a structure composed of multiple proteins responsible for cell-cell adhesion in polarized endothelium and epithelium. This article introduces a new experimental method to study the membrane protein claudins (CLDNs), providing a novel approach for studying other membrane proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Nandhini Rajagopal, Shikha Nangia
Summary: This study investigates the molecular assembly of claudins, specifically claudin-5 and claudin-15, to determine their structural and functional properties. The research findings suggest that each member of the claudin family has a unique strand architecture that requires systematic molecular-level analysis.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Cell Biology
Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin, Ya-Wen Liu, Tse-Hua Tan, Yi-Rong Chen
Summary: This study revealed the importance of DUSP3 as a regulator of epithelial TJ and its decrease may be implicated in the progression of epithelial cancers.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Akira C. Saito, Chisato Endo, Yugo Fukazawa, Tomohito Higashi, Hideki Chiba
Summary: MarvelD3 does not affect the morphology of TJ strands and barrier function in MDCK II cells. The carboxy-terminal cytoplasmic tail of tricellulin is dispensable for barrier improvement.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Haixiong Tang, Zemin Chen, Sudan Gan, Yan Liang, Hailing Zhang, Changyun Yang, Liqin Lin, Yubiao Guo, Shiyue Li, Jing Li, Lihong Yao
Summary: This study demonstrates the crucial role of glucose transporter 1 (GLUT1) in the dysfunction of epithelial tight junctions during the development of acute lung injury (ALI).
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenxian Ma, Qiaoyan Jin, Haiqin Guo, Xinpeng Han, Lingbin Xu, Shemin Lu, Changgui Wu
Summary: This study demonstrates that metformin can alleviate airway inflammation and remodeling in an OVA-induced chronic asthmatic model. The protective effects of metformin may be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Harleen Kaur, Regis Moreau
Summary: The role of mTORC1 in the regulation of intestinal barrier function and permeability remains to be fully elucidated.
Article
Endocrinology & Metabolism
Lars Winkler, Rosel Blasig, Olga Breitkreuz-Korff, Philipp Berndt, Sophie Dithmer, Hans C. Helms, Dmytro Puchkov, Kavi Devraj, Mehmet Kaya, Zhihai Qin, Stefan Liebner, Hartwig Wolburg, Anuska Andjelkovic, Andre Rex, Ingolf E. Blasig, Reiner F. Haseloff
Summary: The study shows that Cldn3 and occludin play a protective role in the stroke by maintaining the integrity of TJ and BBB, but also contribute to the development of edema and infarction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Toxicology
Youting Zhang, Likang Zhang, Wanwan Chen, Yuanyuan Zhang, Xiaoming Wang, Yaoyao Dong, Weixi Zhang, Xixi Lin
Summary: The impact of fine particulate matter (PM2.5) on public health has been increasingly studied, with Shp2 identified as playing a crucial role in PM2.5-induced epithelial barrier dysfunction through the ERK1/2 MAPK signaling pathway.
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Adriana Cortes, Maite Solas, Alvaro Pejenaute, Miguel A. Abellanas, Marcos Garcia-Lacarte, Maria S. Aymerich, Javier Marques, Maria J. Ramirez, Guillermo Zalba
Summary: The study revealed that NADPH oxidase 5 (NOX5) promotes vascular alterations in aged mice and leads to cognitive decline, disrupting the integrity of the blood-brain barrier through oxidative stress.
Article
Respiratory System
Elizabeth J. Becker, Alen Faiz, Maarten van den Berge, Wim Timens, Pieter S. Hiemstra, Kristopher Clark, Gang Liu, Xiaohui Xiao, Yuriy O. Alekseyev, George O'Connor, Stephen Lam, Avrum Spira, Marc E. Lenburg, Katrina Steiling
Summary: The study identified and replicated an airway gene expression signature associated with the rate of FEV1 decline in individuals with COPD. Genes that are elevated in individuals with a more rapid FEV1 decline are significantly enriched among the genes altered by modulation of XBP1 and are related to mucin production. These findings suggest that molecular processes related to the rate of FEV1 decline can be detected in the airway epithelium, potentially serving as an early indicator of rapid FEV1 decline in both smokers with and without COPD.
Article
Pharmacology & Pharmacy
Alexandra M. E. Zuckermann, Roberto M. La Ragione, Deborah L. Baines, Robin S. B. Williams
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Article
Microbiology
Nidhi Sofat, Robin Wait, Saralili D. Robertson, Deborah L. Baines, Emma H. Baker
FRONTIERS IN MICROBIOLOGY
(2015)
Article
Critical Care Medicine
Emma H. Baker, Deborah L. Baines
Article
Respiratory System
Aristides D. Tagalakis, Mustafa M. Munye, Rositsa Ivanova, Hanpeng Chen, Claire M. Smith, Ahmad M. Aldossary, Luca Z. Rosa, Dale Moulding, Josephine L. Barnes, Konstantinos N. Kafetzis, Stuart A. Jones, Deborah L. Baines, Guy W. J. Moss, Christopher O'Callaghan, Robin J. McAnulty, Stephen L. Hart
Article
Pharmacology & Pharmacy
A. Waheed, M. H. R. Ludtmann, N. Pakes, S. Robery, A. Kuspa, C. Dinh, D. Baines, R. S. B. Williams, M. A. Carew
BRITISH JOURNAL OF PHARMACOLOGY
(2014)
Article
Biochemistry & Molecular Biology
James P. Garnett, Daniela Braun, Alex J. McCarthy, Matthew R. Farrant, Emma H. Baker, Jodi A. Lindsay, Deborah L. Baines
CELLULAR AND MOLECULAR LIFE SCIENCES
(2014)
Article
Multidisciplinary Sciences
Simren K. Gill, Kailyn Hui, Hugo Farne, James P. Garnett, Deborah L. Baines, Luke S. P. Moore, Alison H. Holmes, Alain Filloux, John S. Tregoning
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
James Peter Garnett, Kameljit K. Kalsi, Mirko Sobotta, Jade Bearham, Georgina Carr, Jason Powell, Malcolm Brodlie, Christopher Ward, Robert Tarran, Deborah L. Baines
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Kameljit K. Kalsi, James P. Garnett, Wishwanath Patkee, Alexina Weekes, Mark E. Dockrell, Emma H. Baker, Deborah L. Baines
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Cell Biology
Jade Bearham, James P. Garnett, Victoria Schroeder, Matthew G. S. Biggart, Deborah L. Baines
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2019)
Editorial Material
Neurosciences
Deborah L. Baines
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Cell Biology
Tongde Wu, Joe A. Wrennall, Hong Dang, Deborah L. Baines, Robert Tarran
Summary: Primary human bronchial epithelial cultures (HBECs) are useful for studying airway physiology, disease, and drug development, but their expansion through passaging can affect their phenotype and gene expression, as well as their functional properties.
Article
Pharmacology & Pharmacy
Annika Astrand, Cecilia Wingren, Audra Benjamin, John S. Tregoning, James P. Garnett, Helen Groves, Simren Gill, Maria Orogo-Wenn, Anders J. Lundqvist, Dafydd Walters, David M. Smith, John D. Taylor, Emma H. Baker, Deborah L. Baines
BRITISH JOURNAL OF PHARMACOLOGY
(2017)
Article
Physiology
Mustafa M. Munye, Amelia Shoemark, Robert A. Hirst, Juliette M. Delhove, Tyson V. Sharp, Tristan R. McKay, Christopher O'Callaghan, Deborah L. Baines, Steven J. Howe, Stephen L. Hart
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2017)