Review
Endocrinology & Metabolism
Bayley J. Waters, Barak Blum
Summary: Growing evidence suggests that axon guidance molecules play a crucial role in islet morphogenesis and function by regulating cell migration and cell-cell communication.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Elisa Damo, Manuela Simonetti
Summary: Chronic pain is a debilitating condition that affects various aspects of patients' lives, and finding better treatments is of great interest to researchers. Developmental molecules such as Wnt, ephrins, and semaphorins play important roles in the normal growth of biological systems. Their pathways contribute to the development, maintenance, and resolution of pain by impacting both neurons and glial cells. This review summarizes the current understanding of these pathways and their mechanisms in experimental animal models, providing insights into their involvement in the chronicity of pain.
Article
Dentistry, Oral Surgery & Medicine
Minjie Li, Zhongyuan Tang, Chengfei Zhang, Lijian Jin, Koichi Matsuo, Yanqi Yang
Summary: Simultaneous stimulation by LPS and CF significantly suppresses EphB4 expression and enhances ephrinA2 expression. This stimulation also intensifies osteoclastic differentiation, while sequential exposure to LPS and CF only slightly increases osteoclastic cell numbers.
Review
Reproductive Biology
Enoch Appiah Adu-Gyamfi, Armin Czika, Tai-Hang Liu, Philip Narteh Gorleku, Linda Ahenkorah Fondjo, Francis Tanam Djankpa, Yu-Bin Ding, Ying-Xiong Wang
Summary: Ephrins and Eph receptors play important roles in the female reproductive system, regulating various processes and being associated with obstetric and gynecologic disorders.
BIOLOGY OF REPRODUCTION
(2021)
Review
Oncology
Stavros P. Papadakos, Ioanna E. Stergiou, Nikolina Gkolemi, Konstantinos Arvanitakis, Stamatios Theocharis
Summary: This narrative literature review focuses on the role of EPH/ephrin signaling in liver cancer and its implications for tumor progression and potential therapeutic strategies. It highlights the upregulation of HIF-1α in HCC cells under low oxygen conditions and explores the significance of the EPH/ephrin axis in regulating the hypoxic tumor microenvironment. The review also emphasizes the potential of targeting the EPH/ephrin signaling pathway in liver cancer treatment.
Article
Biochemistry & Molecular Biology
Nihal Kaplan, Min Liu, Junyi Wang, Wending Yang, Elaina Fiolek, Han Peng, Robert M. Lavker
Summary: This study demonstrates a link between miR-210 and EphA2/Ephrin-A1 signaling that potentially regulates corneal epithelial migration.
Article
Endocrinology & Metabolism
Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh
Summary: This article reviews the recent advances in understanding the molecular mechanism of skeletal-neural interactions in bone homeostasis, with a focus on the functions of axon guidance molecules in the establishment and maintenance of the skeletal system.
Article
Plant Sciences
Ivan Anchesi, Federica Betto, Luigi Chiricosta, Agnese Gugliandolo, Federica Pollastro, Stefano Salamone, Emanuela Mazzon
Summary: In this study, NSC-34 cells were treated with CBG at a concentration of 10 μM, and the effects of CBG on these cells were evaluated using NGS technology. The analysis showed that CBG activates the WNT/planar cell polarity pathway and Ephrin-Eph signaling. The results indicated that CBG increases the expression of genes associated with cytoskeletal remodeling and axon guidance.
Review
Neurosciences
Kelly G. Sullivan, Greg J. Bashaw
Summary: Friedrich Bonhoeffer made significant contributions to the study of axon guidance in the developing nervous system by uncovering key cellular and molecular mechanisms and cloning important repulsive axon guidance cues. This review highlights his major contributions and ongoing investigations into the regulation of axon repulsion. The post-translational regulation of ephrin and slit ligands and their respective receptors is discussed, with a focus on endocytic trafficking events and receptor signaling. The article aims to identify outstanding questions for future research. Published by Elsevier Ltd. as part of a Special Issue entitled "Prof. Friedrich Bonhoeffer". All rights reserved.
Article
Multidisciplinary Sciences
Gen Honda, Nen Saito, Taihei Fujimori, Hidenori Hashimura, Mitsuru J. Nakamura, Akihiko Nakajima, Satoshi Sawai
Summary: Through quantitative image analysis of Dictyostelium on microfabricated surfaces, it was found that the macropinocytic membrane cup is a distinct mode of topographical guidance driven by the Ras/PI3K/F-actin signaling patch, showing unique responses to micrometer-scale topographical features. This topographical guidance differs from previously known guidance mechanisms that depend on nanometer-scale curvature sensing proteins or stress fibers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Wenqing Li, Lai Wen, Bhavisha Rathod, Anne-Claude Gingras, Klaus Ley, Ho-Sup Lee
Summary: This study reveals that kindlin2 can mediate bi-directional ephrinB signaling through binding to a conserved NIYY motif in the ephrinB2 cytoplasmic tail. The interaction is important for EphB/ephrinB-mediated integrin activation in mammalian cells and blood vessel morphogenesis in zebrafish development.
LIFE SCIENCE ALLIANCE
(2022)
Review
Neurosciences
R. J. Pasterkamp, K. Burk
Summary: The translation explains how axons navigate through the nervous system and the role of endosomes in intracellular signaling. It highlights the importance of endosome trafficking for axon guidance receptors and their localization for proper function and signaling pathways.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Miguel E. Dominguez-Romero, Paula G. Slater
Summary: The growth cone is a critical structure during neuronal development and regeneration, detecting and integrating signals to reach its final destination. After neuronal injuries in mammals, only axons in the peripheral nervous system are able to regenerate, while the ones from the central nervous system fail to do so.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Selma E. Anton, Charlotte Kayser, Isabella Maiellaro, Katarina Nemec, Jan Moeller, Andreas Koschinski, Manuela Zaccolo, Paolo Annibale, Martin Falcke, Martin J. Lohse, Andreas Bock
Summary: Cells use independent cAMP nanodomains to send different signals, which form self-sufficient cell signaling units. Each nanodomain contains a highly localized cAMP pool that is protected from other receptors and cell compartments. The gradients of local cAMP concentrations define the size of each individual nanodomain. The coexistence of many such nanodomains allows a single cell to operate multiple independent cellular signals simultaneously.
Article
Ophthalmology
Victor H. Guaiquil, Cissy Xiao, Daniel Lara, Greigory Dimailig, Qiang Zhou
Summary: Axon guidance proteins and their receptors are abundantly expressed in the cornea and trigeminal ganglia. After corneal epithelium injury, these proteins and receptors quickly recover at the protein and gene expression levels and remain upregulated for several weeks. The initial protein expression recovery may be related to corneal epithelium recovery, and sustained high expression levels may be functionally related to nerve regeneration and/or patterning.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Multidisciplinary Sciences
F. Frottin, F. Schueder, S. Tiwary, R. Gupta, R. Koerner, T. Schlichthaerle, J. Cox, R. Jungmann, F. U. Hartl, M. S. Hipp
Article
Cell Biology
Liang Zhao, Giulia Vecchi, Michele Vendruscolo, Roman Koerner, Manajit Hayer-Hartl, F. Ulrich Hartl
Article
Cell Biology
Jingyi Gong, Thomas N. Gaitanos, Olivia Luu, Yunyun Huang, Louise Gaitanos, Jana Lindner, Rudolf Winklbauer, Rudiger Klein
JOURNAL OF CELL BIOLOGY
(2019)
Article
Neurosciences
Sonia Paixao, Laura Loschek, Louise Gaitanos, Pilar Alcala Morales, Martyn Goulding, Ruediger Klein
Article
Biochemistry & Molecular Biology
Daniel del Toro, Maria A. Carrasquero-Ordaz, Amy Chu, Tobias Ruff, Meriam Shahin, Verity A. Jackson, Matthieu Chavent, Miguel Berbeira-Santana, Goenuel Seyit-Bremer, Sara Brignani, Rainer Kaufmann, Edward Lowe, Ruediger Klein, Elena Seiradake
Article
Neurosciences
Marion Ponserre, Christian Peters, Federica Fermani, Karl-Klaus Conzelmann, Ruediger Klein
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Ruediger Klein, Ronald Jeroen Pasterkamp
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sonja Blumenstock, Elena Katharina Schulz-Trieglaff, Kerstin Voelkl, Anna-Lena Bolender, Paul Lapios, Jana Lindner, Mark S. Hipp, F. Ulrich Hartl, Rudiger Klein, Irina Dudanova
Summary: Researchers have developed reporter mice for neuronal proteostasis, revealing proteostasis decline in the aging brain and in a mouse model of tauopathy. Different types of protein aggregates have distinct effects on cellular protein quality control.
Article
Neurosciences
Catherine Fleitas, Pau Marfull-Oromi, Disha Chauhan, Daniel del Toro, Blanca Peguera, Bahira Zammou, Daniel Rocandio, Rudiger Klein, Carme Espinet, Joaquim Egea
Summary: Neuron migration is important in nervous system development, with FLRTs controlling the distribution of cortical inhibitory interneurons through Unc5 receptors, potentially impacting the development of psychiatric disorders.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Baruch Haimson, Oren Meir, Reut Sudakevitz-Merzbach, Gerard Elberg, Samantha Friedrich, Peter Lovell, Sonia Paixao, Ruediger Klein, Claudio Mello, Avihu Klar
Summary: Flight in birds evolved through wing patterning from forelimbs and transition from alternating gait to synchronous flapping. In mammals, the ephrin-B3 protein guides wiring for limb alternation, with its deletion leading to synchronous hopping gait. The avian ephrin-B3 protein lacks certain motifs found in vertebrates, reducing its affinity for the EphA4 receptor and influencing the development of the brachial spinal cord circuitry.
Article
Neurosciences
Tobias Ruff, Christian Peters, Akihiro Matsumoto, Stephan J. Ihle, Pilar Alcala Morales, Louise Gaitanos, Keisuke Yonehara, Daniel del Toro, Ruediger Klein
Summary: The study introduced a novel genetic Flrt3-CreERT2 knock-in mouse that labels a specific subtype of RGC, and found that these RGC subtypes project to a part of the accessory optic system (AOS) called MTN and preferentially respond to downward motion in an ON-fashion.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biology
Irene Riera-Tur, Tillman Schaefer, Daniel Hornburg, Archana Mishra, Miguel da Silva Padilha, Lorena Fernandez-Mosquera, Dennis Feigenbutz, Patrick Auer, Matthias Mann, Wolfgang Baumeister, Rudiger Klein, Felix Meissner, Nuno Raimundo, Ruben Fernandez-Busnadiego, Irina Dudanova
Summary: This study investigates the effects of protein aggregates on primary neurons. It was found that the aggregates impair the late stages of autophagy, resulting in lysosomal alterations and neurotoxicity. The study also identifies the interaction between β proteins and the AP-3 adaptor complex, which leads to lysosomal defects.
LIFE SCIENCE ALLIANCE
(2022)
Article
Neurosciences
Marion Ponserre, Federica Fermani, Louise Gaitanos, Ruediger Klein
Summary: In order to successfully forage in a rewarding and threatening environment, animals rely on familiar structures of the environment to signal the availability of food. This study found that two major subpopulations of neurons in the central amygdala, CeA(Sst) and CeA(PKC delta) neurons, can assign motivational properties to environmental cues. The activity of CeA(PKC delta) neurons is required for learning contextual food cues.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Christian Peters, Songwei He, Federica Fermani, Hansol Lim, Wenyu Ding, Christian Mayer, Ruediger Klein
Summary: Using single-nucleus RNA sequencing, this study identifies nine clusters of cells in the central amygdala (CeA) and finds that certain cells are associated with appetitive and aversive behaviors. The study focuses on serotonin receptor 2a (Htr2a)-expressing neurons (CeAHtr2a) in the CeA that promote feeding and finds that these neurons are activated by fasting, ghrelin, and the presence of food. They also project to the parabrachial nucleus, inhibiting target neurons and influencing feeding behavior.
Article
Cell Biology
Augusto Escalante, Ruediger Klein