Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes

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Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors

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Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

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Optical Mapping of cAMP Signaling at the Nanometer Scale

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Subcellular Organization of the cAMP Signaling Pathway

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Illuminating G-Protein-Coupling Selectivity of GPCRs

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Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond

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The Molecular Basis of G Protein–Coupled Receptor Activation

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Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

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G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

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Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

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Discovery, characterization, and clinical development of the glucagon-like peptides

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Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots

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Trends in GPCR drug discovery: new agents, targets and indications

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GPCRdb in 2018: adding GPCR structure models and ligands

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Experimental and mathematical analysis of cAMP nanodomains

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FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

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The complexity of signalling mediated by the glucagon-like peptide-1 receptor

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Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes

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Mechanisms Restricting Diffusion of Intracellular cAMP

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cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons

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Signalling scaffolds and local organization of cellular behaviour

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The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

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cAMP signaling in subcellular compartments

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Role of Membrane Microdomains in Compartmentation of cAMP Signaling

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Assembly of allosteric macromolecular switches: lessons from PKA

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Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system

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FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells

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Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, β-arrestin 2, PDE4D3 complex

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Visualization of PKA activity in plasma membrane microdomains

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 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

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Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

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The structure and function of G-protein-coupled receptors

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Enzymatic assembly of DNA molecules up to several hundred kilobases

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Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

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Protein Kinase A Type I and Type II Define Distinct Intracellular Signaling Compartments

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Selective coupling of type 6 adenylyl cyclase with type 2 IP3receptors mediates direct sensitization of IP3receptors by cAMP

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