Kindlin-2 directly binds actin and regulates integrin outside-in signaling

Interaction of kindlin-2 with integrin  3 promotes outside-in signaling responses by the  V 3 vitronectin receptor

(2015) Z. Liao et al.   BLOOD

Direct Interaction of Kindlin-3 With Integrin αIIbβ3 in Platelets Is Required for Supporting Arterial Thrombosis in Mice

(2014) Zhen Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Integrin function in vascular biology

(2014) Edward F. Plow et al.   CURRENT OPINION IN HEMATOLOGY

Molecular Basis of Kindlin-2 Binding to Integrin-linked Kinase Pseudokinase for Regulating Cell Adhesion

(2014) Koichi Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation

(2014) C. Huet-Calderwood et al.   JOURNAL OF CELL SCIENCE

Diverse functions of kindlin/fermitin proteins during embryonic development in Xenopus laevis

(2014) Tania Rozario et al.   MECHANISMS OF DEVELOPMENT

Tracing the evolution of FERM domain of Kindlins

(2014) Raja Hashim Ali et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

(2013) Feng Ye et al.   CURRENT BIOLOGY

The eukaryotic linear motif resource ELM: 10 years and counting

(2013) Holger Dinkel et al.   NUCLEIC ACIDS RESEARCH

A Role of Kindlin-3 in Integrin αMβ2 Outside-In Signaling and the Syk-Vav1-Rac1/Cdc42 Signaling Axis

(2013) Zhi-Hong Xue et al.   PLoS One

The Integrin-Linked Kinase-PINCH-Parvin Complex Supports Integrin αIIbβ3 Activation

(2013) Shigenori Honda et al.   PLoS One

Spatial Coordination of Kindlin-2 with Talin Head Domain in Interaction with Integrin β Cytoplasmic Tails

(2012) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Molecular Mechanism for the Requirement of PAT-4 (Integrin-linked Kinase (ILK)) for the Localization of UNC-112 (Kindlin) to Integrin Adhesion Sites

(2012) Hiroshi Qadota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-3 Mediates Integrin αLβ2 Outside-in Signaling, and It Interacts with Scaffold Protein Receptor for Activated-C Kinase 1 (RACK1)

(2012) Chen Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional differences between kindlin-1 and kindlin-2 in keratinocytes

(2012) A. Bandyopadhyay et al.   JOURNAL OF CELL SCIENCE

Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation

(2012) Yan Liu et al.   Protein & Cell

The integrin coactivator Kindlin-2 plays a critical role in angiogenesis in mice and zebrafish

(2011) E. Pluskota et al.   BLOOD

Structural Basis of Phosphoinositide Binding to Kindlin-2 Protein Pleckstrin Homology Domain in Regulating Integrin Activation

(2011) Jianmin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins

(2011) H. Qu et al.   JOURNAL OF CELL SCIENCE

Membrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin Activation

(2011) H. Dhanuja Perera et al.   STRUCTURE

Kindlins in FERM adhesion

(2010) N. L. Malinin et al.   BLOOD

Tyrosine Phosphorylation of Integrin β3Regulates Kindlin-2 Binding and Integrin Activation

(2010) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Integrin Co-activator Kindlin-3 Is Expressed and Functional in a Non-hematopoietic Cell, the Endothelial Cell

(2010) Katarzyna Bialkowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

(2010) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Kindlin-2 in Fibroblast Functions: Implications for Wound Healing

(2010) Yinghong He et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NMR analysis of the  IIb 3 cytoplasmic interaction suggests a mechanism for integrin regulation

(2010) D. G. Metcalf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycogenome expression dynamics during mouse C2C12 myoblast differentiation suggests a sequential reorganization of membrane glycoconjugates

(2009) Mathilde Janot et al.   BMC GENOMICS

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

The Kindlin protein family: new members to the club of focal adhesion proteins

(2009) Alexander Meves et al.   TRENDS IN CELL BIOLOGY

Comparative study of ezrin phosphorylation among different tissues: more is good; too much is bad

(2008) Lixin Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

LAD-1/variant syndrome is caused by mutations inFERMT3

(2008) Taco W. Kuijpers et al.   BLOOD

Kindlin-3: a new gene involved in the pathogenesis of LAD-III

(2008) A. Mory et al.   BLOOD

Kindlin-2 is required for myocyte elongation and is essential for myogenesis

(2008) James J Dowling et al.   BMC CELL BIOLOGY

Kindlin-2 Is an Essential Component of Intercalated Discs and Is Required for Vertebrate Cardiac Structure and Function

(2008) James J. Dowling et al.   CIRCULATION RESEARCH

Kindlins: essential regulators of integrin signalling and cell–matrix adhesion

(2008) Hannu Larjava et al.   EMBO REPORTS

Kindlin-2 controls bidirectional signaling of integrins

(2008) E. Montanez et al.   GENES & DEVELOPMENT

Kindlin-2 (Mig-2): a co-activator of β3integrins

(2008) Yan-Qing Ma et al.   JOURNAL OF CELL BIOLOGY

Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction

(2008) Siegfried Ussar et al.   PLoS Genetics