GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK

The far C-terminus of MCAK regulates its conformation and spindle pole focusing

(2016) Hailing Zong et al.   MOLECULAR BIOLOGY OF THE CELL

NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity

(2016) Chenyu Li et al.   Scientific Reports

The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

(2015) Sandeep K Talapatra et al.   eLife

The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle

(2015) Faye M Nixon et al.   eLife

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

(2015) Mourad Sanhaji et al.   Oncotarget

The mitotic origin of chromosomal instability

(2014) Samuel F. Bakhoum et al.   CURRENT BIOLOGY

Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells

(2014) Alexander Braun et al.   JOURNAL OF CELL BIOLOGY

Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program

(2014) Prathapan Thiru et al.   MOLECULAR BIOLOGY OF THE CELL

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

(2014) Norman Ertych et al.   NATURE CELL BIOLOGY

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Nucleotide Exchange in Dimeric MCAK Induces Longitudinal and Lateral Stress at Microtubule Ends to Support Depolymerization

(2014) Kyle M. Burns et al.   STRUCTURE

Aurora B Inhibits MCAK Activity through a Phosphoconformational Switch that Reduces Microtubule Association

(2013) Stephanie C. Ems-McClung et al.   CURRENT BIOLOGY

Coordination of adjacent domains mediates TACC3–ch-TOG–clathrin assembly and mitotic spindle binding

(2013) Fiona E. Hood et al.   JOURNAL OF CELL BIOLOGY

Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension

(2013) L. P. Cheeseman et al.   JOURNAL OF CELL SCIENCE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The cancer biology of whole-chromosome instability

(2013) P H G Duijf et al.   ONCOGENE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

A Double-Edged Sword: How Oncogenes and Tumor Suppressor Genes Can Contribute to Chromosomal Instability

(2013) Bernardo Orr et al.   Frontiers in Oncology

Doublecortin Recognizes the 13-Protofilament Microtubule Cooperatively and Tracks Microtubule Ends

(2012) Susanne Bechstedt et al.   DEVELOPMENTAL CELL

MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment

(2012) Sarah B. Domnitz et al.   JOURNAL OF CELL BIOLOGY

Mitotic spindle (DIS)orientation and DISease: Cause or consequence?

(2012) Anna Noatynska et al.   JOURNAL OF CELL BIOLOGY

Causes and consequences of aneuploidy in cancer

(2012) David J. Gordon et al.   NATURE REVIEWS GENETICS

GTSE1 Is a Microtubule Plus-End Tracking Protein That Regulates EB1-Dependent Cell Migration

(2012) Massimilano Scolz et al.   PLoS One

A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging

(2011) Daniel G Booth et al.   EMBO JOURNAL

Kif18B interacts with EB1 and controls astral microtubule length during mitosis

(2011) Jane R. Stout et al.   MOLECULAR BIOLOGY OF THE CELL

Nup98 regulates bipolar spindle assembly through association with microtubules and opposition of MCAK

(2011) Marie K. Cross et al.   MOLECULAR BIOLOGY OF THE CELL

K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly

(2011) Sylvain Meunier et al.   NATURE CELL BIOLOGY

High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes

(2011) Alexander W Bird et al.   NATURE METHODS

PLK1 Phosphorylates Mitotic Centromere-associated Kinesin and Promotes Its Depolymerase Activity

(2010) Liangyu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long astral microtubules uncouple mitotic spindles from the cytokinetic furrow

(2010) Kathleen E. Rankin et al.   JOURNAL OF CELL BIOLOGY

Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability

(2010) Chiou-Hong Lin et al.   JOURNAL OF CELL BIOLOGY

Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions

(2010) Nina C. Hubner et al.   JOURNAL OF CELL BIOLOGY

Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment

(2010) W. Fu et al.   JOURNAL OF CELL SCIENCE

Functional and Spatial Regulation of Mitotic Centromere- Associated Kinesin by Cyclin-Dependent Kinase 1

(2010) Mourad Sanhaji et al.   MOLECULAR AND CELLULAR BIOLOGY

Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

(2009) Samuel F. Bakhoum et al.   CURRENT BIOLOGY

TIP150 interacts with and targets MCAK at the microtubule plus ends

(2009) Kai Jiang et al.   EMBO REPORTS

MCAK and Paclitaxel Have Differential Effects on Spindle Microtubule Organization and Dynamics

(2009) Rania S. Rizk et al.   MOLECULAR BIOLOGY OF THE CELL

Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK

(2009) Jeremy R Cooper et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A

(2008) Alexander W. Bird et al.   JOURNAL OF CELL BIOLOGY

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

(2008) Ina Poser et al.   NATURE METHODS