A murine model of large-scale bone regeneration reveals a selective requirement for Sonic Hedgehog

A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting

(2021) Ximeng Han et al.   Cell Stem Cell

Direct contribution of skeletal muscle mesenchymal progenitors to bone repair

(2021) Anais Julien et al.   Nature Communications

Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function

(2021) Amy J. Petty et al.   JCI Insight

Hedgehog signaling regulates metabolism and polarization of mammary tumor-associated macrophages

(2021) Dominique C. Hinshaw et al.   CANCER RESEARCH

Tracing the skeletal progenitor transition during postnatal bone formation

(2021) Hui Sophie Shu et al.   Cell Stem Cell

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

(2020) Yuki Matsushita et al.   Nature Communications

Skeletal stem cells: insights into maintaining and regenerating the skeleton

(2020) Maxwell A. Serowoky et al.   DEVELOPMENT

Growth plate skeletal stem cells and their transition from cartilage to bone

(2020) Yuki Matsushita et al.   BONE

Modulation of the Inflammatory Response and Bone Healing

(2020) Masahiro Maruyama et al.   Frontiers in Endocrinology

Identification of a regeneration-organizing cell in the Xenopus tail

(2019) C. Aztekin et al.   SCIENCE

Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib

(2019) Stephanie T Kuwahara et al.   eLife

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

(2019) Silvia Pietrobono et al.   Frontiers in Genetics

Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin

(2018) Oriane Duchamp de Lageneste et al.   Nature Communications

Discovery of a periosteal stem cell mediating intramembranous bone formation

(2018) Shawon Debnath et al.   NATURE

Knockdown Indian Hedgehog (Ihh) does not delay Fibular Fracture Healing in genetic deleted Ihh mice and pharmaceutical inhibited Ihh Mice

(2018) Shengchun Li et al.   Scientific Reports

The use of commercially available adhesive tapes to preserve cartilage and bone tissue integrity during cryosectioning

(2018) Maxwell A Serowoky et al.   BIOTECHNIQUES

Mechanical stimulation promote the osteogenic differentiation of bone marrow stromal cells through epigenetic regulation of Sonic Hedgehog

(2017) Chuandong Wang et al.   EXPERIMENTAL CELL RESEARCH

A minimally sufficient model for rib proximal-distal patterning based on genetic analysis and agent-based simulations

(2017) Jennifer L Fogel et al.   eLife

Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow

(2016) Rui Yue et al.   Cell Stem Cell

Expression of homeobox genes in the mouse olfactory epithelium

(2016) Marta Parrilla et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Natural Large-Scale Regeneration of Rib Cartilage in a Mouse Model

(2015) Marissa K Srour et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sonic Hedgehog Produced by Bone Marrow-Derived Mesenchymal Stromal Cells Supports Cell Survival in Myelodysplastic Syndrome

(2015) Jixue Zou et al.   Stem Cells International

A Surgical Procedure for Resecting the Mouse Rib: A Model for Large-Scale Long Bone Repair

(2015) Nikita Tripuraneni et al.   Jove-Journal of Visualized Experiments

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

A Mechanical Jack-like Mechanism Drives Spontaneous Fracture Healing in Neonatal Mice

(2014) Chagai Rot et al.   DEVELOPMENTAL CELL

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

(2014) Noriaki Ono et al.   NATURE CELL BIOLOGY

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation

(2013) Gurpreet S Baht et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Injectable gel graft for bone defect repair

(2013) Josephine Fang et al.   Regenerative Medicine

Hedgehog-Gli Pathway Activation during Kidney Fibrosis

(2012) Steven L. Fabian et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog

(2012) C.-i. Lau et al.   BLOOD

Hedgehog Signaling in Hematopoiesis

(2012) Yiting Lim et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer

(2011) Hideya Onishi et al.   CANCER SCIENCE

Activation of the Hh Pathway in Periosteum-Derived Mesenchymal Stem Cells Induces Bone Formation in Vivo

(2010) Qun Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons

(2010) Tsunemitsu Soeda et al.   GENESIS

Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair

(2009) Yan Yiu Yu et al.   BONE

Skeletal Cell Fate Decisions Within Periosteum and Bone Marrow During Bone Regeneration

(2008) Céline Colnot   JOURNAL OF BONE AND MINERAL RESEARCH

Hypoxia induces a hedgehog response mediated by HIF-1α

(2008) Maarten F. Bijlsma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration

(2008) Giuseppe Straface et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE