A multi-organ chip with matured tissue niches linked by vascular flow

Bioinformatic analysis of peripheral blood miRNA of breast cancer patients in relation with anthracycline cardiotoxicity

(2020) Wang Yadi et al.   BMC Cardiovascular Disorders

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

(2020) Richard Novak et al.   Nature Biomedical Engineering

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

(2020) Martin Trapecar et al.   Cell Systems

A pharmacokinetic–pharmacodynamic model based on multi-organ-on-a-chip for drug–drug interaction studies

(2020) Kenta Shinha et al.   Biomicrofluidics

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Human skin explant model for the investigation of topical therapeutics

(2020) Jessica E. Neil et al.   Scientific Reports

A deep proteome and transcriptome abundance atlas of 29 healthy human tissues

(2019) Dongxue Wang et al.   Molecular Systems Biology

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

(2019) Christopher W. McAleer et al.   Science Translational Medicine

Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype

(2019) Kacey Ronaldson-Bouchard et al.   Nature Protocols

miRDB: an online database for prediction of functional microRNA targets

(2019) Yuhao Chen et al.   NUCLEIC ACIDS RESEARCH

ShinyGO: a graphical gene-set enrichment tool for animals and plants

(2019) Steven Xijin Ge et al.   BIOINFORMATICS

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

(2018) Rachelle Prantil-Baun et al.   Annual Review of Pharmacology and Toxicology

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Streamlined Tandem Mass Tag (SL-TMT) Protocol: An Efficient Strategy for Quantitative (Phospho)proteome Profiling Using Tandem Mass Tag-Synchronous Precursor Selection-MS3

(2018) José Navarrete-Perea et al.   JOURNAL OF PROTEOME RESEARCH

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

RBiomirGS: an all-in-one miRNA gene set analysis solution featuring target mRNA mapping and expression profile integration

(2018) Jing Zhang et al.   PeerJ

Identification of a Novel microRNA Profile in Pediatric Cancer Patients treated with Anthracycline Chemotherapy

(2018) Kelsie E. Oatmen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data

(2018) Steven Xijin Ge et al.   BMC BIOINFORMATICS

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

(2018) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation

(2018) Haoyu Zeng et al.   TOXICOLOGICAL SCIENCES

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

(2017) William J. Polacheck et al.   NATURE

Tissue-Engineered Model of Human Osteolytic Bone Tumor

(2017) Aranzazu Villasante et al.   TISSUE ENGINEERING PART C-METHODS

Circulating microRNAs: Potential Markers of Cardiotoxicity in Children and Young Adults Treated With Anthracycline Chemotherapy

(2017) Kasey J. Leger et al.   Journal of the American Heart Association

Computational approaches for modeling and analysis of human-on-chip systems for drug testing and characterization

(2016) Mahadevabharath R. Somayaji et al.   DRUG DISCOVERY TODAY

Engineering a perfusable 3D human liver platform from iPS cells

(2016) Arnout Schepers et al.   LAB ON A CHIP

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Tissue-engineered autologous grafts for facial bone reconstruction

(2016) Sarindr Bhumiratana et al.   Science Translational Medicine

Circulating miR-1 as a potential biomarker of doxorubicin-induced cardiotoxicity in breast cancer patients

(2016) Vagner Oliveira-Carvalho Rigaud et al.   Oncotarget

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats

(2015) Yu Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The relevance and potential roles of microphysiological systems in biology and medicine

(2014) John P Wikswo   EXPERIMENTAL BIOLOGY AND MEDICINE

The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations

(2014) Yuanbin Ru et al.   NUCLEIC ACIDS RESEARCH

Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research

(2014) Tove Tuntland et al.   Frontiers in Pharmacology

Generation of 3D Skin Equivalents Fully Reconstituted from Human Induced Pluripotent Stem Cells (iPSCs)

(2013) Munenari Itoh et al.   PLoS One

Bone scaffold architecture modulates the development of mineralized bone matrix by human embryonic stem cells

(2012) Ivan Marcos-Campos et al.   BIOMATERIALS

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Doxorubicin pathways

(2010) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE