A Novel Domain-Specific Mutation in a Sclerosteosis Patient Suggests a Role of LRP4 as an Anchor for Sclerostin in Human Bone

Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption

(2015) Lei Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Truncating mutations inLRP4lead to a prenatal lethal form of Cenani-Lenz syndrome

(2014) Amanda S. Lindy et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

LRP4 Is Critical for Neuromuscular Junction Maintenance

(2014) A. Barik et al.   JOURNAL OF NEUROSCIENCE

Romosozumab in Postmenopausal Women with Low Bone Mineral Density

(2014) Michael R. McClung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels

(2014) Ming-Kang Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner

(2013) Bisei Ohkawara et al.   HUMAN MOLECULAR GENETICS

Single- and Multiple-Dose Randomized Studies of Blosozumab, a Monoclonal Antibody Against Sclerostin, in Healthy Postmenopausal Women

(2013) Juliet McColm et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Van Buchem disease: Clinical, biochemical, and densitometric features of patients and disease carriers

(2012) Antoon H van Lierop et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Autoantibodies to Lipoprotein-Related Protein 4 in Patients With Double-Seronegative Myasthenia Gravis

(2011) John S. Tzartos   ARCHIVES OF NEUROLOGY

Identification of the first deletion in the LRP5 gene in a patient with Autosomal Dominant Osteopetrosis type I

(2011) Alessandra Pangrazio et al.   BONE

Bone Overgrowth-associated Mutations in theLRP4Gene Impair Sclerostin Facilitator Function

(2011) Olivier Leupin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis

(2011) Alexandra Pevzner et al.   JOURNAL OF NEUROLOGY

LRP4 Mutations Alter Wnt/β-Catenin Signaling and Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome

(2010) Yun Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis

(2010) Osamu Higuchi et al.   ANNALS OF NEUROLOGY

Sclerosteosis - An autosomal recessive disorder

(2010) Peter Beighton et al.   CLINICAL GENETICS

First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function

(2010) Elke Piters et al.   HUMAN MUTATION

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo

(2009) Hong Y. Choi et al.   PLoS One

The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations

(2008) Wendy Balemans et al.   CALCIFIED TISSUE INTERNATIONAL