Article
Immunology
DQ. Cai, Diankui Cai, Yiping Zou, Xumeng Chen, Zhixiang Jian, Mude Shi, Ye Lin, Jueming Chen
Summary: CD8+ T cell exhaustion has been found to negatively impact immunotherapy outcomes. The molecular functions and mechanisms of action of this exhaustion in chemoresistance are still unclear. In this study, a chemoresistant TILCD8T signature (cr-TILCD8TSig) was identified using gene expression data, and it was found to independently predict prognosis, chemotherapy response, and immunotherapy outcomes in breast cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Kaili Liao, Qijun Yang, Yuhan Xu, Yingcheng He, Jingyi Wang, Zimeng Li, Chengfeng Wu, Jialing Hu, Xiaozhong Wang
Summary: This study identified specific marker genes for CD8+ T cell subsets in colon cancer and constructed a prognostic evaluation model. The model was able to predict the prognosis and drug response of patients with colon cancer. The study found that certain genes had high mutation rates in specific risk groups, and patients in the high-risk group had lower drug response rates.
CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sara Valpione, Piyushkumar A. Mundra, Elena Galvani, Luca G. Campana, Paul Lorigan, Francesco De Rosa, Avinash Gupta, John Weightman, Sarah Mills, Nathalie Dhomen, Richard Marais
Summary: High baseline T cell receptor diversity is predictive of favorable prognosis in multiple cancer types, while monoclonal expansion of T cells pre-treatment correlates with good response to immune checkpoint blockade therapy in metastatic melanoma patients.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Raquel Benitez, Katherine Yu, Marina Sirota, Nuria Malats, Silvia Pineda
Summary: This study analyzed the tumor-infiltrating B and T cell repertoire in the tumor microenvironment of MIBC and found differences among different MIBC subtypes. The Basal/Squamous-like and Stroma-rich subtypes showed higher infiltration and were associated with better survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yangyang Guo, Yingjue Zhang, Kenan Cen, Ying Dai, Yifeng Mai, Kai Hong
Summary: In this study, we identified an ideal prognostic signature based on positive regulators of T cell function in gastric cancer, which has significant clinical potential.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Yifang Sun, Jian Wu, Yonggang Yuan, Yumin Lu, Ming Luo, Ling Lin, Shengsheng Ma
Summary: The study identified a gene signature based on CD8+ T-cell-associated immune-related genes for predicting prognosis and immunotherapy response in uveal melanoma (UM) patients. This gene signature was effective in predicting overall survival (OS) and metastasis-free survival (MFS) of UM patients, categorizing them into high- and low-risk subgroups with distinct clinical characteristics, CD8+ T-cell immune infiltration, and immunotherapy response. Gene set enrichment analysis (GSEA) indicated activation of immune pathways in low-risk UM phenotype.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Bingzhi Wang, Yongjian Zhu, Shaoming Wang, Zhuo Li, Long Wang, Wei Rao, Na Cheng, Rongshan Chen, Jianming Ying, Liyan Xue
Summary: TADNI is a special morphological subtype with poorer prognoses and unique molecular characteristics, which might benefit from CXCR1/CXCR2 inhibitors.
Article
Immunology
Zeev Elkoshi
Summary: Tumor-infiltrating lymphocytes, particularly the frequencies of regulatory T cells (Tregs) and CD8+ T cells, are important prognostic markers in cancer. The correlation between intra-tumoral Tregs and survival can vary depending on the type of cancer. This study suggests using the frequency ratio of lymphocytes as the preferred marker in most cancer types, as it shows a direct correlation with survival and is less variable compared to individual lymphocyte frequencies. However, if the frequency of one lymphocyte is highly variable, it may be beneficial to focus on the lymphocyte with a less variable frequency to improve the correlation with survival, especially when the intra-tumoral frequencies of the two species are inversely correlated. The marker selected using this approach may also be a good predictor of checkpoint inhibitor therapy success.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Konrad Lehr, Darja Nikitina, Ramiro Vilchez-Vargas, Ruta Steponaitiene, Cosima Thon, Jurgita Skieceviciene, Denny Schanze, Martin Zenker, Peter Malfertheiner, Juozas Kupcinskas, Alexander Link
Summary: The mucosal microbial community in the stomach is associated with worse overall survival in gastric cancer patients, with the genus Fusobacterium and Prevotella being significantly associated with poor prognosis. The abundance of Fusobacterium nucleatum in tumorous specimens has the strongest negative impact on prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Konrad Lehr, Darja Nikitina, Ramiro Vilchez-Vargas, Ruta Steponaitiene, Cosima Thon, Jurgita Skieceviciene, Denny Schanze, Martin Zenker, Peter Malfertheiner, Juozas Kupcinskas, Alexander Link
Summary: Helicobacter pylori (H. pylori) infection is the main cause of gastric cancer, but other bacterial species may also play a role. This study found that the mucosal microbial community in the stomach is associated with the prognosis of gastric cancer. The abundance of Fusobacterium and Prevotella is significantly associated with worse overall survival in gastric cancer patients.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Silvia Pineda, Evangelina Lopez de Maturana, Katharine Yu, Akshay Ravoor, Ines Wood, Nuria Malats, Marina Sirota
Summary: The study found that PDAC tumor tissue had richer and more diverse IG and TCR infiltration compared to normal pancreatic tissue. Specific IG clonotypes could help differentiate samples with better prognosis, while a larger TCR infiltration was associated with patients with a history of diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Xinyue Li, Jing Yang
Summary: This study investigated the relationship between tumor deposits and clinicopathological characteristics, tumor-infiltrating lymphocytes, and prognosis in gastric cancer. The results showed a significant association between tumor deposits and various characteristics and prognosis of gastric cancer, with patients having more than 4 tumor deposits having a worse prognosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Hematology
Kohta Miyawaki, Koji Kato, Takeshi Sugio, Kensuke Sasaki, Hiroaki Miyoshi, Yuichiro Semba, Yoshikane Kikushige, Yasuo Mori, Yuya Kunisaki, Hiromi Iwasaki, Toshihiro Miyamoto, Frank C. Kuo, Jon C. Aster, Koichi Ohshima, Takahiro Maeda, Koichi Akashi
Summary: This study evaluated the impact of the microenvironment on clinical outcomes and molecular features in DLBCL. It found that the presence of normal GC-microenvironmental cells in lymphoma tissue is associated with a positive therapeutic response and established an independent prognostic model. Additionally, DLBCL tissues lacking GC-microenvironmental cells showed an increased incidence of genomic alterations and aberrant gene expression associated with poor prognosis.
Article
Immunology
Guanghao Li, Yongheng Liu, Yanting Zhang, Yao Xu, Jin Zhang, Xianfu Wei, Zhongmin Zhang, Chao Zhang, Jinyan Feng, Qiang Li, Guowen Wang
Summary: This study explores the prognostic value of ferroptosis-related lncRNAs in HCC patients. A novel signature consisting of five ferroptosis-related lncRNAs is established and shown to have a high clinical application value in predicting overall survival. The findings suggest that this signature could serve as an efficient indicator for predicting prognosis and guiding treatment in HCC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Xin-Bin Pan, Yan Lu, De-Sheng Yao
Summary: Through gene expression profiles and the CIBERSORT algorithm, the study identified 22 types of tumor-infiltrating immune cells in endometrial adenocarcinoma patients, with the abundance of M0 macrophages and CD8 T cells correlating with patient prognosis.
Letter
Surgery
Xiaoyin Bai, Linfeng Zou, Qiang Wang, Aiming Yang
ASIAN JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Zhiyu Yan, Cheng Zhu, Xi Wu, Huijuan Zhu, Tao Yuan, Yaping Luo, Yunlu Feng, Qiang Wang, Shengyu Zhang, Huadan Xue, Zehui Zheng, Aiming Yang
Summary: Insulinomas are a common type of pancreatic neuroendocrine tumor that causes symptoms and severe impairment in patients due to high insulin levels and subsequent hypoglycemia. Surgery is usually the first choice but carries a high risk of complications. Ethanol ablation is a promising non-surgical option for tumor shrinking, but there is insufficient evidence for its impact on symptom control and long-term efficacy.
Article
Computer Science, Information Systems
Tianyi Zhang, Yunlu Feng, Yu Zhao, Guangda Fan, Aiming Yang, Shangqing Lyu, Peng Zhang, Fan Song, Chenbin Ma, Yangyang Sun, Youdan Feng, Guanglei Zhang
Summary: Pancreatic cancer is a highly lethal malignant tumor, but its diagnosis can be accelerated by using the rapid on-site evaluation (ROSE) technique. However, the shortage of experienced pathologists has hindered the wider use of ROSE diagnosis. Deep learning shows potential in automatically classifying ROSE images, but modeling the complex local and global image features is challenging. Therefore, a multi-stage hybrid Transformer (MSHT) is proposed to combine the advantages of both traditional convolutional neural networks (CNN) and Transformer structures, achieving improved accuracy and attention regions.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Ziying Han, Xianlin Han, Yuan Li, Yunlu Feng, Shengyu Zhang, Aiming Yang
ENDOSCOPIC ULTRASOUND
(2023)
Editorial Material
Gastroenterology & Hepatology
Guizhi Zhang, Qingwei Jiang, Shengyu Zhang, Dongsheng Wu, Yaping Luo, Weixun Zhou, Aiming Yang
ENDOSCOPIC ULTRASOUND
(2023)
Article
Medicine, General & Internal
Ziqi Wan, Xiaoyin Bai, Chengqing He, Yueyi Zhang, Ying Wang, Kaini Shen, Meizi Li, Qiang Wang, Dongsheng Wu, Yunlu Feng, Aiming Yang
Summary: This study described the clinical characteristics of gallstones following chronic haemolytic anaemia and compared them with the general gallstone population. The lipid profile of haemolytic anaemia patients with gallstones was distinct, with low total cholesterol and high-density lipoprotein, and increased or normal low-density lipoprotein. Elderly patients were more likely to develop gallstones in a shorter period after anaemia, and abdominal ultrasound and frequent follow-up visits were recommended for chronic haemolytic anaemia patients older than 50 years old.
ANNALS OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Qiu Shi Xu, Yan You, Shuang Liu, Wen You, Sheng Yu Zhang, Jing Nan Li, Ai Ming Yang, Ji Li, Jia Ming Qian
Summary: This study aimed to explore the endoscopic features of different histopathological patterns of colorectal polyps in Cronkhite-Canada syndrome (CCS). The results showed that the endoscopic features, including size, color, sessility, Kudo's pit pattern classification, and endoscopic activity, could help identify the histopathological patterns of colorectal polyps in CCS.
JOURNAL OF DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yongru Liu, Dingkun Xiong, Yu Zhao, Zhilan Meng, Xi Wu, Qingwei Jiang, Qiang Wang, Dongsheng Wu, Shengyu Zhang, Yunlu Feng, Aiming Yang
Summary: Self-ROSE significantly improves the accuracy and sensitivity of EUS-FNA alone and EUS-TA diagnosis of solid pancreatic lesions. However, whether self-ROSE benefits EUS-FNB and whether EUS-FNB alone is comparable to EUS-FNA with self-ROSE need further clarification.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Shengyu Zhang, Zhiyu Yan, Yuheng Zhang, Xi Wu, Li Liu, Aiming Yang, Mengjie Duan
Summary: This randomized controlled trial (RCT) aims to establish a state-of-the-art protocol for quantifying the multiroute exposure of medical staff to infectious particles exhaled by patients during real oesophagogastroduodenoscopy (OGD) procedures. The study will use an anthropomorphic model to simulate a medical staff member and will assess the dosage of exhaled infectious particles in the airway and facial mucosa of the model with or without a surgical mask. The results of this study will be disseminated through presentations and publications in peer-reviewed journals.
Review
Medicine, General & Internal
Xinyuan Cao, Yingyun Yang, Yizhen Zhang, Ruoyu Ji, Xinyu Zhao, Weiyang Zheng, Aiming Yang
Summary: This study aims to identify changes in gastrointestinal microbiota composition between patients with H. pylori-infective and non-infective chronic gastritis through a systematic review and meta-analysis. The results of this study may provide new insights into future diagnosis and treatments.
Article
Medicine, General & Internal
Qingwei Jiang, Xiaxiao Yan, Duan Wang, Shengyu Zhang, Yuelun Zhang, Yunlu Feng, Aiming Yang, Dong Wu
Summary: This study aims to compare the efficacy of cold snare polypectomy (CSP) and hot snare polypectomy (HS-EMR) in the resection of 10-19 mm non-pedunculated colorectal polyps. The results will have implications for future clinical practice and guideline development.
Review
Immunology
Yuhao Jiao, Zhiyu Yan, Aiming Yang
Summary: Autoimmune diseases involve complex immune response alterations, with the exact pathogenesis remaining unclear. Recent research has focused on the functions of mitochondria, which play crucial roles in cell differentiation, maturation, and death. This review summarizes the role of mitochondria in the innate immune response and its dysfunction in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, with a focus on its impact on cellular metabolism and regulation of immune signaling pathways. Additionally, potential therapeutic targets in mitochondrial regulation for autoimmune diseases are discussed, highlighting the need for further research.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Peng Li, Zheng Zhang, Sheng Wang, Zhendong Jin, Yiqi Du, Aiming Yang, Yunlu Feng, Xiaoping Zou, Lei Wang, Xiaoyan Wang, Li Tian, Pinghong Zhou, Yiqun Zhang, Jun Liu, Zhen Ding, Junwen Zhang, Jian Yang, Siyu Sun, Shutian Zhang
Summary: This study evaluated the safety and efficacy of the Hot AXIOS system for PFC drainage in a multicenter Chinese cohort. The results showed that stent placement was successful in all patients and 93.3% of patients achieved clinical success within 60 days after surgery. The study found that a previous pancreatitis attack > 6 months prior was associated with a greater chance of achieving 100% remission of PFCs within 1 month.
ENDOSCOPIC ULTRASOUND
(2023)
Review
Oncology
Yongru Liu, Huanwen Wu, Xi Wu, Yunlu Feng, Qingwei Jiang, Qiang Wang, Aiming Yang
Summary: Gastroblastoma is an extremely rare stomach tumor that primarily occurs in adolescents and young adults, with a biphasic cell morphology of epithelioid and spindle cells. Most patients survive after surgical treatment with no evidence of disease. A diagnosis of gastroblastoma should be considered in cases with characteristic histopathology and immunohistochemistry patterns, even without a MALAT1-GLI1 fusion.
Article
Medicine, General & Internal
Long Zou, Qingwei Jiang, Tao Guo, Xi Wu, Qiang Wang, Yunlu Feng, Shengyu Zhang, Weigang Fang, Weixun Zhou, Aiming Yang
Summary: This study aimed to evaluate predictive factors to identify malignancies misdiagnosed as low-grade intraepithelial neoplasia (LGIN) by biopsy and LGIN at high risk of progression. The study found that a single lesion, a large lesion size, and marked intestinal metaplasia (IM) were independent predictors of initially misdiagnosed malignancies; a whitish appearance, irregular margins, marked IM, and a histological diagnosis of LGIN more than twice within the first year were predictors for progression.
CHINESE MEDICAL JOURNAL
(2022)
