Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of Leukocyte Concentration on the Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis

(2015) Jonathan C. Riboh et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Targeting VEGF-A with a vaccine decreases inflammation and joint destruction in experimental arthritis

(2015) Luca Semerano et al.   ANGIOGENESIS

A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain

(2015) Deepitha Selvaraj et al.   CANCER CELL

Hydrostatic Pressure Influences HIF-2 Alpha Expression in Chondrocytes

(2015) Hiroaki Inoue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crizotinib Improves Osteoarthritis Symptoms in a ROS1-Fusion Advanced Non–Small Cell Lung Cancer Patient

(2015) Jordi Remon et al.   Journal of Thoracic Oncology

Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Injecting vascular endothelial growth factor into the temporomandibular joint induces osteoarthritis in mice

(2015) Pei Shen et al.   Scientific Reports

Elevated VEGF levels contribute to the pathogenesis of osteoarthritis

(2015) Quan Yuan et al.   BMC MUSCULOSKELETAL DISORDERS

The Effect of Vascular Endothelial Growth Factor on Osteoclastogenesis in Rheumatoid Arthritis

(2015) Hae-Rim Kim et al.   PLoS One

Efficacy of intra-articular bevacizumab for relapsing diffuse-type giant cell tumour

(2014) M J Nissen et al.   ANNALS OF THE RHEUMATIC DISEASES

Mechanical Forces Induce Changes in VEGF and VEGFR-1/sFlt-1 Expression in Human Chondrocytes

(2014) Rainer Beckmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Angiogenic cytokine expression profiles in plasma and synovial fluid of primary knee osteoarthritis

(2014) Thomas Mabey et al.   INTERNATIONAL ORTHOPAEDICS

Animal data show VEGF blocker inhibits post-traumatic OA

(2014) Caroline Barranco   Nature Reviews Rheumatology

Bevacizumab, an anti-vascular endothelial growth factor antibody, inhibits osteoarthritis

(2014) Toshihiro Nagai et al.   ARTHRITIS RESEARCH & THERAPY

Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes

(2014) Anika I Tsuchida et al.   ARTHRITIS RESEARCH & THERAPY

Dkk-1-Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice

(2014) Thomas Funck-Brentano et al.   Arthritis & Rheumatology

Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature

(2013) K Ghasemi Falavarjani et al.   EYE

Avastin Exhibits Therapeutic Effects on Collagen-Induced Arthritis in Rat Model

(2013) Yong Wang et al.   INFLAMMATION

Relationship of plasma and synovial fluid vascular endothelial growth factor with radiographic severity in primary knee osteoarthritis

(2013) Natthaphon Saetan et al.   INTERNATIONAL ORTHOPAEDICS

Vascular endothelial growth factor signaling in injured nerves underlies peripheral sensitization in neuropathic pain

(2013) Norikazu Kiguchi et al.   JOURNAL OF NEUROCHEMISTRY

Therapeutic effects of sunitinib, one of the anti-angiogenetic drugs, in a murine arthritis

(2013) Kazuhiro Furuya et al.   Modern Rheumatology

Disease-modifying drugs for knee osteoarthritis: can they be cost-effective?

(2013) E. Losina et al.   OSTEOARTHRITIS AND CARTILAGE

Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review

(2013) Y. Zhu et al.   OSTEOARTHRITIS AND CARTILAGE

In vitro and in vivo angiogenic activity of osteoarthritic and osteoporotic osteoblasts is modulated by VEGF and vitamin D3 treatment

(2013) Anna Neve et al.   REGULATORY PEPTIDES

Engineering endostatin-expressing cartilaginous constructs using injectable biopolymer hydrogels

(2012) Lily Jeng et al.   Acta Biomaterialia

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Recombinant human endostatin inhibits adjuvant arthritis by down-regulating VEGF expression and suppression of TNF-α, IL-1β production

(2012) Wei Hu et al.   INFLAMMATION RESEARCH

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

(2012) Yanqiu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain management

(2012) Laura McKelvey et al.   JOURNAL OF NEUROCHEMISTRY

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

(2012) Paul I. Mapp et al.   Nature Reviews Rheumatology

Vatalanib decrease the positive interaction of VEGF receptor-2 and P2X2/3 receptor in chronic constriction injury rats

(2012) Shuangmei Liu et al.   NEUROCHEMISTRY INTERNATIONAL

The Impact of Osteoarthritis in the United States

(2012) Louise Murphy et al.   Orthopaedic Nursing

Injection of vascular endothelial growth factor into knee joints induces osteoarthritis in mice

(2012) A. Ludin et al.   OSTEOARTHRITIS AND CARTILAGE

The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair

(2012) Y. Mifune et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis as a disease of mechanics

(2012) D.T. Felson   OSTEOARTHRITIS AND CARTILAGE

Chondroclasts are mature osteoclasts which are capable of cartilage matrix resorption

(2012) H. J. Knowles et al.   VIRCHOWS ARCHIV

Characterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate

(2012) Cécile Lambert et al.   ARTHRITIS RESEARCH & THERAPY

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

(2012) Jing Li et al.   ARTHRITIS RESEARCH & THERAPY

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes

(2011) Petra Juffer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

(2011) Patrick W. Mantyh et al.   ANESTHESIOLOGY

Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue

(2011) Patricia Klinger et al.   ARTHRITIS AND RHEUMATISM

Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis

(2011) Sadaf Ashraf et al.   ARTHRITIS AND RHEUMATISM

Expression of vascular endothelial growth factor in normal, osteoarthritic and osteoporotic osteoblasts

(2011) Addolorata Corrado et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Suramin ameliorates collagen induced arthritis

(2011) Debasis Sahu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A SYSTEMATIC REVIEW OF THE ADVERSE EVENTS OF INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS

(2011) Margriet I Van der Reis et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

The effect of vascular endothelial growth factor on aggrecan and type II collagen expression in rat articular chondrocytes

(2011) Xuan-yin Chen et al.   RHEUMATOLOGY INTERNATIONAL

Systemic and Ocular Safety of Intravitreal Anti-VEGF Therapies for Ocular Neovascular Disease

(2011) Michael Tolentino   SURVEY OF OPHTHALMOLOGY

Thrombospondin-1 Prevents Excessive Ossification in Cartilage Repair Tissue Induced by Osteogenic Protein-1

(2011) Kolja Gelse et al.   TISSUE ENGINEERING PART A

Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis

(2010) S. Ashraf et al.   ANNALS OF THE RHEUMATIC DISEASES

Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model

(2010) Hee-Jeong Im et al.   ARTHRITIS AND RHEUMATISM

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis

(2010) David J Hunter et al.   BMC MUSCULOSKELETAL DISORDERS

VEGF and its receptor-2 involved in neuropathic pain transmission mediated by P2X2/3 receptor of primary sensory neurons

(2010) Jiari Lin et al.   BRAIN RESEARCH BULLETIN

The evolving role of obesity in knee osteoarthritis

(2010) MaryFran R Sowers et al.   CURRENT OPINION IN RHEUMATOLOGY

Biphasic positive effect of formononetin on metabolic activity of human normal and osteoarthritic subchondral osteoblasts

(2010) Jeong-Eun Huh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47

(2010) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular Endothelial Growth Factor and Spinal Cord Injury Pain

(2010) Olivera Nesic et al.   JOURNAL OF NEUROTRAUMA

Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis

(2010) Jeng-Long Hsieh et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Blood-induced joint disease: the pathophysiology of hemophilic arthropathy

(2010) L. A. VALENTINO   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The basic science of the subchondral bone

(2010) Henning Madry et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α

(2010) Katsuya Nakamura et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

(2010) Nancy E. Lane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis

(2010) D. A. Walsh et al.   RHEUMATOLOGY

Engineering Endostatin-Producing Cartilaginous Constructs for Cartilage Repair Using Nonviral Transfection of Chondrocyte-Seeded and Mesenchymal-Stem-Cell-Seeded Collagen Scaffolds

(2010) Lily Jeng et al.   TISSUE ENGINEERING PART A

Intravenous administration of anti-vascular endothelial growth factor humanized monoclonal antibody bevacizumab improves articular cartilage repair

(2010) Toshihiro Nagai et al.   ARTHRITIS RESEARCH & THERAPY

Calcification of articular cartilage in human osteoarthritis

(2009) M. Fuerst et al.   ARTHRITIS AND RHEUMATISM

Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cells

(2009) Seiji Kubo et al.   ARTHRITIS AND RHEUMATISM

Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble flt-1

(2009) Tomoyuki Matsumoto et al.   ARTHRITIS AND RHEUMATISM

Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

(2009) Tania M. Hansen et al.   CELLULAR SIGNALLING

VEGF165 Promotes the Osteolytic Bone Destruction of Ewing's Sarcoma Tumors by Upregulating RANKL

(2009) Hui Guan et al.   ONCOLOGY RESEARCH

Osteochondral angiogenesis and increased protease inhibitor expression in OA

(2009) R.E. Fransès et al.   OSTEOARTHRITIS AND CARTILAGE

Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer

(2009) Andre F Steinert et al.   ARTHRITIS RESEARCH & THERAPY

Thrombospondins function as regulators of angiogenesis

(2009) Paul Bornstein   Journal of Cell Communication and Signaling

Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter

(2008) Peter Zimmermann et al.   ARTHRITIS AND RHEUMATISM

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone

(2008) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffolds

(2008) Xiao-Dan Sun et al.   BIOMATERIALS

Therapeutic effect of anti-vascular endothelial growth factor receptor I antibody in the established collagen-induced arthritis mouse model

(2008) Sang Tae Choi et al.   CLINICAL RHEUMATOLOGY

An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis

(2008) D. D. Lazarus et al.   INFLAMMATION RESEARCH

VEGF enhancement of osteoclast survival and bone resorption involves VEGF receptor-2 signaling and β3-integrin

(2008) Q YANG et al.   MATRIX BIOLOGY

The potential role of vascular endothelial growth factor (VEGF) in cartilage

(2007) M. Murata et al.   OSTEOARTHRITIS AND CARTILAGE