ALKBH5 regulates STAT3 activity to affect the proliferation and tumorigenicity of osteosarcoma via an m6A-YTHDF2-dependent manner
出版年份 2022 全文链接
标题
ALKBH5 regulates STAT3 activity to affect the proliferation and tumorigenicity of osteosarcoma via an m6A-YTHDF2-dependent manner
作者
关键词
Osteosarcoma, m6A, ALKBH5, YTHDF2, STAT3, SOCS3
出版物
EBioMedicine
Volume 80, Issue -, Pages 104019
出版商
Elsevier BV
发表日期
2022-04-29
DOI
10.1016/j.ebiom.2022.104019
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma
- (2021) Ye Yuan et al. Cell Death & Disease
- ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma
- (2020) Shuo Chen et al. Cancer Cell International
- M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma
- (2020) Xueliang Zuo et al. Journal of Hematology & Oncology
- The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis
- (2020) Mengnuo Chen et al. Molecular Cancer
- m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling
- (2020) Bo Tang et al. Molecular Cancer
- A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
- (2020) Sara Zaccara et al. CELL
- Roles of METTL3 in cancer: mechanisms and therapeutic targeting
- (2020) Chengwu Zeng et al. Journal of Hematology & Oncology
- The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
- (2019) Maosheng Cheng et al. ONCOGENE
- m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner
- (2019) Ruifan Wu et al. Cell Death & Disease
- The Critical Role of RNA m6A Methylation in Cancer
- (2019) Qing Lan et al. CANCER RESEARCH
- The role of m6A RNA methylation in human cancer
- (2019) Xiao-Yu Chen et al. Molecular Cancer
- METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma
- (2019) Ting Li et al. Molecular Cancer
- m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
- (2019) Seungwon Yang et al. Nature Communications
- The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1
- (2019) Wujun Miao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Molecular characterization and clinical relevance of m6A regulators across 33 cancer types
- (2019) Yongsheng Li et al. Molecular Cancer
- The HOTAIR/miR-214/ST6GAL1 crosstalk modulates colorectal cancer procession through mediating sialylated c-Met via JAK2/STAT3 cascade
- (2019) Bing Liu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Epigenetic regulation of m6A modifications in human cancer
- (2019) Wei Zhao et al. Molecular Therapy-Nucleic Acids
- IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader
- (2019) Xiaoge Hu et al. CELL DEATH AND DIFFERENTIATION
- m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis
- (2019) Dan Jin et al. Journal of Hematology & Oncology
- Functions of N6-methyladenosine and its role in cancer
- (2019) Liuer He et al. Molecular Cancer
- m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma
- (2019) Li Liu et al. Molecular Cancer
- The role of STAT3 in leading the crosstalk between human cancers and the immune system
- (2018) Yu Wang et al. CANCER LETTERS
- R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling
- (2018) Rui Su et al. CELL
- METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification
- (2018) Hengyou Weng et al. Cell Stem Cell
- Role of N 6 -methyladenosine modification in cancer
- (2018) Xiaolan Deng et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
- (2018) Mengnuo Chen et al. HEPATOLOGY
- Multiple functions of m6A RNA methylation in cancer
- (2018) Yutian Pan et al. Journal of Hematology & Oncology
- m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
- (2018) Jun Liu et al. NATURE CELL BIOLOGY
- METTL3 regulates WTAP protein homeostasis
- (2018) Melissa Sorci et al. Cell Death & Disease
- Tumor-associated macrophages promote lung metastasis and induce epithelial-mesenchymal transition in osteosarcoma by activating the COX-2/STAT3 axis
- (2018) Yu Han et al. CANCER LETTERS
- Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells
- (2018) Dongqing Zuo et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma
- (2018) Li Zhong et al. CANCER LETTERS
- Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia
- (2017) Chau-To Kwok et al. Journal of Hematology & Oncology
- m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition
- (2017) Boxuan Simen Zhao et al. NATURE
- The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
- (2017) Ly P Vu et al. NATURE MEDICINE
- Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
- (2017) A Visvanathan et al. ONCOGENE
- Apatinib promotes autophagy and apoptosis through VEGFR2/STAT3/BCL-2 signaling in osteosarcoma
- (2017) Kuisheng Liu et al. Cell Death & Disease
- Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth
- (2017) Xing Bao et al. Cell Death & Disease
- m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
- (2017) Qi Cui et al. Cell Reports
- HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3
- (2016) K Yuan et al. CELL DEATH AND DIFFERENTIATION
- Post-transcriptional gene regulation by mRNA modifications
- (2016) Boxuan Simen Zhao et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- N6-methyladenosine–encoded epitranscriptomics
- (2016) Nian Liu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- N6-methyladenosine–encoded epitranscriptomics
- (2016) Nian Liu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
- (2015) Shay Geula et al. SCIENCE
- Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
- (2012) Kate D. Meyer et al. CELL
- Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
- (2012) Dan Dominissini et al. NATURE
- A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
- (2010) Li Lin et al. Molecular Cancer
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