10 Years of GWAS discovery in endometrial cancer: Aetiology, function and translation
出版年份 2022 全文链接
标题
10 Years of GWAS discovery in endometrial cancer: Aetiology, function and translation
作者
关键词
Endometrial cancer, Genome-wide association study (GWAS), Risk factors, Cross-trait analysis, Functional analysis, Polygenic risk scores
出版物
EBioMedicine
Volume 77, Issue -, Pages 103895
出版商
Elsevier BV
发表日期
2022-02-23
DOI
10.1016/j.ebiom.2022.103895
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cancer Statistics, 2021
- (2021) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Genetics of 35 blood and urine biomarkers in the UK Biobank
- (2021) Nasa Sinnott-Armstrong et al. NATURE GENETICS
- A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization
- (2021) Jue-Sheng Ong et al. Nature Communications
- Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts
- (2021) Rebecca E. Graff et al. Nature Communications
- No Evidence for a Causal Relationship Between Cancers and Parkinson’s Disease
- (2021) Konstantin Senkevich et al. Journal of Parkinsons Disease
- Genetically Raised Circulating Bilirubin Levels and Risk of Ten Cancers: A Mendelian Randomization Study
- (2021) Nazlisadat Seyed Seyed Khoei et al. Cells
- Combined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk
- (2021) Burcu F. Darst et al. EUROPEAN UROLOGY
- Associations between Genetically Predicted Circulating Protein Concentrations and Endometrial Cancer Risk
- (2021) Jingjing Zhu et al. Cancers
- Testosterone, sex hormone-binding globulin, insulin-like growth factor-1 and endometrial cancer risk: observational and Mendelian randomization analyses
- (2021) Amy Mullee et al. BRITISH JOURNAL OF CANCER
- Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus
- (2021) Pik Fang Kho et al. HUMAN GENETICS
- Genetic insights into biological mechanisms governing human ovarian ageing
- (2021) Katherine S. Ruth et al. NATURE
- Multi-tissue transcriptome-wide association study identifies eight candidate genes and tissue-specific gene expression underlying endometrial cancer susceptibility
- (2021) Pik Fang Kho et al. Communications Biology
- Enhancer Domains Predict Gene Pathogenicity and Inform Gene Discovery in Complex Disease
- (2020) Xinchen Wang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Using human genetics to understand the disease impacts of testosterone in men and women
- (2020) Katherine S Ruth et al. NATURE MEDICINE
- Is Type 2 Diabetes Mellitus Causally Associated with Cancer Risk? Evidence From a Two-Sample Mendelian Randomisation Study
- (2020) Shuai Yuan et al. DIABETES
- Evaluating polygenic risk scores in assessing risk of nine solid and hematologic cancers in European descendants
- (2020) Jungyoon Choi et al. INTERNATIONAL JOURNAL OF CANCER
- Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
- (2020) Kazuyoshi Ishigaki et al. NATURE GENETICS
- Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
- (2020) Yan Dora Zhang et al. Nature Communications
- Smoking, alcohol consumption, and cancer: A mendelian randomisation study in UK Biobank and international genetic consortia participants
- (2020) Susanna C. Larsson et al. PLOS MEDICINE
- Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks
- (2020) Lars G. Fritsche et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A Mendelian randomization study identified obesity as a causal risk factor of uterine endometrial cancer in Japanese
- (2020) Tatsuo Masuda et al. CANCER SCIENCE
- Regulation of adipocyte differentiation by clusterin‐mediated Krüppel‐like factor 5 stabilization
- (2020) Gyun‐Sik Oh et al. FASEB JOURNAL
- Circulating adipokine concentrations and risk of five obesity‐related cancers: a Mendelian randomization study
- (2020) Niki L Dimou et al. INTERNATIONAL JOURNAL OF CANCER
- Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study
- (2020) Shuai Yuan et al. EBioMedicine
- Genetic Susceptibility to Endometrial Cancer: Risk Factors and Clinical Management
- (2020) Thilo Dörk et al. Cancers
- Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction
- (2020) Linda Kachuri et al. Nature Communications
- Assessing the Role of Selenium in Endometrial Cancer Risk: A Mendelian Randomization Study
- (2019) Pik Fang Kho et al. Frontiers in Oncology
- Estrogen Signaling in Endometrial Cancer: a Key Oncogenic Pathway with Several Open Questions
- (2019) Adriana C. Rodriguez et al. Hormones & Cancer
- Opportunities and challenges for transcriptome-wide association studies
- (2019) Michael Wainberg et al. NATURE GENETICS
- Genome-wide association studies of endometrial cancer: Latest developments and future directions.
- (2019) Tracy A O'Mara et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- The proportion of endometrial cancers associated with Lynch syndrome: a systematic review of the literature and meta-analysis
- (2019) N. A. J. Ryan et al. GENETICS IN MEDICINE
- Hysterectomy-Corrected Uterine Corpus Cancer Incidence Trends and Differences in Relative Survival Reveal Racial Disparities and Rising Rates of Nonendometrioid Cancers
- (2019) Megan A. Clarke et al. JOURNAL OF CLINICAL ONCOLOGY
- Benefits and limitations of genome-wide association studies
- (2019) Vivian Tam et al. NATURE REVIEWS GENETICS
- Identifying Putative Susceptibility Genes and Evaluating Their Associations with Somatic Mutations in Human Cancers
- (2019) Zhishan Chen et al. AMERICAN JOURNAL OF HUMAN GENETICS
- GWAS of five gynecologic diseases and cross-trait analysis in Japanese
- (2019) Tatsuo Masuda et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening
- (2019) Matteo Boretto et al. NATURE CELL BIOLOGY
- Analysis of Promoter-Associated Chromatin Interactions Reveals Biologically Relevant Candidate Target Genes at Endometrial Cancer Risk Loci
- (2019) Tracy A. O’Mara et al. Cancers
- Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke
- (2019) Gad Abraham et al. Nature Communications
- The Post-GWAS Era: From Association to Function
- (2018) Michael D. Gallagher et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Comprehensive Characterization of Cancer Driver Genes and Mutations
- (2018) Matthew H. Bailey et al. CELL
- Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses
- (2018) Jodie N. Painter et al. Cancer Medicine
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci
- (2018) David Stacey et al. NUCLEIC ACIDS RESEARCH
- Identification of nine new susceptibility loci for endometrial cancer
- (2018) Tracy A. O’Mara et al. Nature Communications
- Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women
- (2018) Megan A. Clarke et al. JAMA Internal Medicine
- Risk Factors for Endometrial Cancer: An umbrella review of the literature
- (2018) O. Raglan et al. INTERNATIONAL JOURNAL OF CANCER
- Association Between Polycystic Ovary Syndrome and Cancer Risk
- (2018) Weiyao Yin et al. JAMA Oncology
- Family history of cancer predicts endometrial cancer risk independently of Lynch Syndrome: Implications for genetic counselling
- (2017) Sharon E. Johnatty et al. GYNECOLOGIC ONCOLOGY
- International Patterns and Trends in Endometrial Cancer Incidence, 1978–2013
- (2017) Joannie Lortet-Tieulent et al. JNCI-Journal of the National Cancer Institute
- Association analysis identifies 65 new breast cancer risk loci
- (2017) Kyriaki Michailidou et al. NATURE
- Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
- (2017) Felix R Day et al. NATURE GENETICS
- The druggable genome and support for target identification and validation in drug development
- (2017) Chris Finan et al. Science Translational Medicine
- International Patterns and Trends in Endometrial Cancer Incidence, 1978–2013
- (2017) Joannie Lortet-Tieulent et al. JNCI-Journal of the National Cancer Institute
- Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases
- (2017) et al. JAMA Oncology
- Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer
- (2016) J. N. Painter et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Endometriosis and risks for ovarian, endometrial and breast cancers: A nationwide cohort study
- (2016) Julie Brøchner Mogensen et al. GYNECOLOGIC ONCOLOGY
- Five endometrial cancer risk loci identified through genome-wide association analysis
- (2016) Timothy H T Cheng et al. NATURE GENETICS
- CYP19A1fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer
- (2015) Deborah J Thompson et al. ENDOCRINE-RELATED CANCER
- Increased Association Between Endometriosis and Endometrial Cancer
- (2015) Hann-Chin Yu et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis
- (2015) Kevin T. Nead et al. JNCI-Journal of the National Cancer Institute
- Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1
- (2015) Timothy HT Cheng et al. Scientific Reports
- Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis
- (2015) Kevin T. Nead et al. JNCI-Journal of the National Cancer Institute
- Body Mass Index Genetic Risk Score and Endometrial Cancer Risk
- (2015) Jennifer Prescott et al. PLoS One
- Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk
- (2014) Jodie N. Painter et al. HUMAN MOLECULAR GENETICS
- Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis
- (2014) John A. Barry et al. HUMAN REPRODUCTION UPDATE
- Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer
- (2012) J. Long et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- The Epidemiology of Endometrial and Ovarian Cancer
- (2011) Daniel W. Cramer HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
- Genome-wide association study identifies a common variant associated with risk of endometrial cancer
- (2011) Amanda B Spurdle et al. NATURE GENETICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started