Article
Geriatrics & Gerontology
Hye-Yeon Lee, Ji-Hyeon Lee, Seung Hyung Kim, Su-Yeon Jo, Kyung-Jin Min
Summary: This study evaluated the anti-aging effects of Lactobacillus reuteri on the lifespan and physiology of fruit flies. It found that L. reuteri significantly increased the mean lifespan of fruit flies without affecting reproductive output, food intake, or locomotor activity. The study suggests that the longevity effect of L. reuteri is mediated by the reduction of the insulin/IGF-1 signaling pathway and the action of reuterin.
Article
Geriatrics & Gerontology
Hye-Yeon Lee, Ji-Hyeon Lee, Seung Hyung Kim, Su-Yeon Jo, Kyung-Jin Min
Summary: This study found that L. reuteri has anti-aging effects and can significantly extend the average lifespan of fruit flies. Furthermore, the effects of L. reuteri do not affect the reproductive output, food intake, or locomotor activity of fruit flies. The results suggest that the anti-aging effects of L. reuteri are mediated by the reduction of the insulin/IGF-1 signaling pathway and the action of reuterin.
Article
Medicine, General & Internal
Wenlong Zhang, Jie Huang, Feng Gao, Qianglong You, Liuyan Ding, Junwei Gong, Mengran Zhang, Runfang Ma, Shaohui Zheng, Xiangdong Sun, Yunlong Zhang
Summary: The study reveals that Cntnap4 deficiency leads to social behavior and fear memory deficits in mice. Reduced GABAergic transmission was observed in the amygdala of Cntnap4-/- mice. Microbiota supplementation through Lactobacillus treatment or faecal transplantation can improve fear memory abnormalities caused by Cntnap4 deficiency.
Article
Microbiology
Theresa L. Montgomery, Korin Eckstrom, Katarina H. Lile, Sydney Caldwell, Eamonn R. Heney, Karolyn G. Lahue, Angelo D'Alessandro, Matthew J. Wargo, Dimitry N. Krementsov
Summary: The study found that gut commensal, such as the potential probiotic species Lactobacillus reuteri, can unexpectedly enhance autoimmunity through tryptophan metabolism, leading to broad shifts in the metabolome and immunological repertoire.
Article
Polymer Science
Punnisa Kasibut, Jintakorn Kuvatanasuchati, Boonyanit Thaweboon, Irin Sirisoontorn
Summary: This study investigated the bacterial communities adhering to acrylic retainers using sequencing technology. The results showed significant differences in the bacterial communities before and after cleaning. The study found a combination of chemical and mechanical cleaning methods to be the most effective in eliminating retainer biofilms, and retainer cleaning tablets did not alter the balance of bacterial communities.
Article
Microbiology
Karin Schwaiger, Julia Storch, Christoph Bauer, Johann Bauer
Summary: L. reuteri is important for the intestinal health of newborn calves, and oral administration of preselected L. reuteri isolates can significantly reduce the incidence of diarrhea in newborn calves. This study provides evidence supporting the use of L. reuteri as a potential protective measure against diarrhea in dairy farms.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Nathalia Louize Nunes Vieira Silva, Alvaro Della Bona, Moises Cardoso, Sidia Maria Callegari-Jacques, Fernando Fornari
Summary: The probiotic Lactobacillus brevis CD2 was found to reduce the duration of traumatic oral lesions and alleviate pain caused by fixed orthodontic appliances, though it did not significantly improve oral health-related quality of life in comparison to a placebo.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2021)
Article
Microbiology
Hao-Yu Liu, Antoine Giraud, Cedric Seignez, David Ahl, Feilong Guo, John Sedin, Tomas Walden, Jee-Hwan Oh, Jan Peter van Pijkeren, Lena Holm, Stefan Roos, Stefan Bertilsson, Mia Phillipson
Summary: The study shows that oral administration of the probiotic bacterium Limosilactobacillus reuteri R2LC increases the numbers and effector functions of B cell subsets, leading to enhanced IgA production, altered intestinal microbiota, and protection against inflammation.
Article
Biochemistry & Molecular Biology
Mackenzie J. Bender, Alex C. McPherson, Catherine M. Phelps, Surya P. Pandey, Colin R. Laughlin, Jake H. Shapira, Luzmariel Medina Sanchez, Mohit Rana, Tanner G. Richie, Tahliyah S. Mims, Angela M. Gocher-Demske, Luisa Cervantes-Barragan, Steven J. Mullett, Stacy L. Gelhaus, Tullia C. Bruno, Nikki Cannon, John A. McCulloch, Dario A. A. Vignali, Reinhard Hinterleitner, Alok V. Joglekar, Joseph F. Pierre, Sonny T. M. Lee, Diwakar Davar, Hassane M. Zarour, Marlies Meisel
Summary: The use of probiotics, specifically Lactobacillus reuteri, has been shown to enhance antitumor immunity and facilitate immune checkpoint inhibitor (ICI) treatment in preclinical melanoma. This is achieved through the release of the tryptophan catabolite indole-3-aldehyde (I3A), which promotes interferon-gamma-producing CD8 T cells within the tumor microenvironment. The signaling of the aryl hydrocarbon receptor (AhR) within CD8 T cells is necessary for the antitumor effects of Lactobacillus reuteri and I3A.
Article
Microbiology
Kevimy Agossa, Marie Dubar, Gregoire Lemaire, Alessandra Blaizot, Celine Catteau, Emmanuel Bocquet, Laurent Nawrocki, Emile Boyer, Vincent Meuric, Florence Siepmann
Summary: This study aims to evaluate the effect of probiotic administration in addition to tooth brushing on oral health in orthodontic patients. The study will assess the impact of probiotics through clinical assessment and biological sample collection, while monitoring compliance outcomes and adverse events.
Article
Multidisciplinary Sciences
Eleonora Colantoni, Francesca Palone, Vincenzo Cesi, Beatrice Leter, Giulia Sugoni, Ilaria Laudadio, Anna Negroni, Roberta Vitali, Laura Stronati
Summary: This study demonstrated for the first time that the microalgae I. galbana is an excellent culture medium for the probiotic L. reuteri. The fermented compound derived from the growth of L. reuteri in I. galbana was shown to significantly reduce the adhesiveness and invasiveness of harmful Escherichia coli. These findings open up new possibilities for the use of microalgae as growth media for probiotics and the production of biofunctional compounds.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zuzana Marincak Vrankova, Margarita Rousi, Michaela Cvanova, Daniela Gachova, Filip Ruzicka, Veronika Hola, Jan Lochman, Lydie Izakovicova Holla, Alena Brysova, Petra Borilova Linhartova
Summary: This pilot study found that the application of fixed orthodontic appliances on both upper and lower arches can lead to changes in oral microbial diversity and an increase in plaque index. The study highlights the importance of a comprehensive approach in research of this kind, as the association between clinical characteristics and combined microbial parameters is stronger than when evaluated separately.
Article
Biochemistry & Molecular Biology
Alexis Espinal, Michael W. Epperly, Amitava Mukherjee, Renee Fisher, Donna Shields, Hong Wang, M. Saiful Huq, Diala Fatima Hamade, Anda M. Vlad, Lan Coffman, Ronald Buckanovich, Jian Yu, Brian J. Leibowitz, Jan-Peter van Pijkeren, Ravi B. Patel, Donna Stolz, Simon Watkins, Asim Ejaz, Joel S. Greenberger
Summary: Gavaging Lactobacillus reuteri-Interleukin-22 (LR-IL-22) improves the delivery of IL-22 to the irradiated intestine and effectively mitigates radiation damage. Compared to the control group, gavaging LR-IL-22 improves multiple biomarkers associated with radiation damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xinwu Wang, Yalu Ji, Cao Qiu, Hao Zhang, Lanting Bi, Hengyu Xi, Liancheng Lei, Bing Liu, Wenyu Han, Jingmin Gu
Summary: In this study, the effects of a combination therapy using a phage cocktail (Pc) and Lactobacillus reuteri (L. reuteri) in an S. typhimurium-induced colitis murine model were compared. The combination therapy resulted in complete removal of S. typhimurium and significant improvement in intestinal barrier and colonic pathological damage. Short-chain fatty acid (SCFA) levels were also increased in the combination therapy group. Additionally, the combination of Pc with acetate and reuterin released by L. reuteri (PcReAc) showed similar effects. This study provides a new concept for the treatment of inflammatory diseases caused by intestinal pathogens.
Article
Biotechnology & Applied Microbiology
Soyon Mann, Myeong Soo Park, Tony V. Johnston, Geun Eog Ji, Keum Taek Hwang, Seockmo Ku
Summary: The research successfully isolated L. gasseri HHuMIN D from the human body, which showed high inhibitory effects against oral pathogens and halitosis-producing anaerobic microorganisms. This strain demonstrated potential as a safe and effective probiotic for promoting human oral health.
MICROBIAL CELL FACTORIES
(2021)
Review
Microbiology
Chaminda J. Seneviratne, Tanujaa Suriyanarayanan, Armelia Sari Widyarman, Lye Siang Lee, Matthew Lau, Jianhong Ching, Christopher Delaney, Gordon Ramage
CRITICAL REVIEWS IN MICROBIOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Armelia Sari Widyarman, Nadeeka S. Udawatte, Citra Fragrantia Theodorea, Anie Apriani, Mario Richi, Tri Erri Astoeti, Chaminda Jayampath Seneviratne
Summary: The study showed that the CPP-ACP/F treatment modulated the dysbiotic oral microbiome towards a healthier state, increasing the abundance of certain microbial protective species. Although the overall community structure in children with caries was relatively uniform, there were significant differences in bacterial species before and after treatment. Three bacterial species were found to be strongly sensitive to the CPP-ACP/F treatment, indicating potential clinical significance of this varnish treatment in modulating the dental plaque microbiome.
JOURNAL OF DENTISTRY
(2021)
Article
Geriatrics & Gerontology
Fatimah Maria Tadjoedin, Sri Lelyati C. Masulili, Muhammad Ihsan Rizal, Lindawati S. Kusdhany, Yuda Turana, Raden Irawati Ismail, Boy M. Bachtiar
Summary: This study aimed to evaluate the subgingival microbiome in elderly Indonesian subjects with periodontitis and cognitive impairment. The findings showed differences in the subgingival microbiota between the cognitively impaired and cognitively normal groups, with a higher abundance of Porphyromonas and Treponema bacteria in the cognitive impairment group. These results suggest a potential link between subgingival microbiota and cognitive impairment, highlighting the need for further investigation into the pathogenesis of cognitive impairment.
Article
Environmental Sciences
Citra Fragrantia Theodorea, Saint Diven, Devin Hendrawan, Ariadna Adisattya Djais, Boy Muchlis Bachtiar, Armelia Sari Widyarman, Chaminda Jayampath Seneviratne
Summary: This study found differences in oral Veillonella profiles between healthy and stunted children, particularly in Indonesia's East Nusa Tenggara province, suggesting a potential association between oral Veillonella species and stunting in children.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chaminda Jayampath Seneviratne, Preethi Balan, Ruklanthi de Alwis, Nadeeka S. Udawatte, Thanuja Herath, Justin Z. N. Toh, Goh Bee Tin, Eng Eong Ooi, Jenny Low Guek Hong, Jean Sim Xiang Ying
Summary: This study evaluated the antibody response in oral fluids of healthcare workers following vaccination with the Pfizer/BioNTech-BNT162b2 vaccine. The results showed that gingival crevicular fluid had higher detection rates and titers of antibodies compared to saliva, and had a stronger correlation with serum antibodies. The researchers suggest that gingival crevicular fluid could be a less invasive alternative to serum for monitoring antibody responses to COVID-19 vaccines.
INTERNATIONAL DENTAL JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Armelia Sari Widyarman, Citra Fragrantia Theodorea, Nadeeka S. Udawatte, Aradhea Monica Drestia, Endang W. Bachtiar, Tri Erri Astoeti, Boy M. Bachtiar
Summary: This study aimed to investigate the differences in oral microbiome of Indonesian women in urban and rural areas. The results showed significant differences in oral microbiome between urban and rural areas, with two bacterial taxa present at significantly higher levels in urban women.
FRONTIERS IN ORAL HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Tri Erri Astoeti, Howis Josephine, Armelia Sari Widyarman, Widijanto Sudhana
Summary: During the COVID-19 pandemic, dental students collectively displayed moderate perceived stress scores. There was a positive correlation between dental environmental stressors and perceived stress among dental students.
KESMAS-NATIONAL PUBLIC HEALTH JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Armelia Sari Widyarman, Triska Ramajayanti, Citra Fragrantia Theodorea
OPEN DENTISTRY JOURNAL
(2020)