Intestinal Radiation Protection and Mitigation by Second-Generation Probiotic Lactobacillus-reuteri Engineered to Deliver Interleukin-22

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

(2022) Teng Ma et al.   NATURE

Lactobacillus reuteri Releasing IL-22 (LR-IL-22) Facilitates Intestinal Radioprotection for Whole-Abdomen Irradiation (WAI) of Ovarian Cancer

(2022) Diala F. Hamade et al.   RADIATION RESEARCH

“Longitudinal Fecal Microbiome Study of Total Body Irradiated Mice Treated With Radiation Mitigators Identifies Bacterial Associations With Survival”

(2021) Kelvin Li et al.   Frontiers in Cellular and Infection Microbiology

B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity

(2021) Baihao Zhang et al.   NATURE

Metabolic modulation of tumours with engineered bacteria for immunotherapy

(2021) Fernando P. Canale et al.   NATURE

Regulation of intestinal immunity and tissue repair by enteric glia

(2021) Fränze Progatzky et al.   NATURE

Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme

(2021) Jing Huang et al.   Nature Chemistry

Interferon b drives intestinal regeneration after radiation

(2021) Brian J. Leibowitz et al.   Science Advances

Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis

(2020) Stephanie Thermozier et al.   RADIATION RESEARCH

Organoids reveal that inherent radiosensitivity of small and large intestinal stem cells determines organ sensitivity

(2019) Maria Laura Martin et al.   CANCER RESEARCH

Second-generation Probiotics Producing IL-22 Increase Survival of Mice After Total Body Irradiation

(2019) XICHEN ZHANG et al.   IN VIVO

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

(2018) Marlies Meisel et al.   NATURE

Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways

(2018) Justin Steinman et al.   RADIATION RESEARCH

The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice

(2018) Liang Wei et al.   Scientific Reports

Lack of Fc Gamma Receptor IIIA Promotes Rather than Suppresses Humoral and Cellular Immune Responses after Mucosal or Parenteral Immunization with Antigen and Adjuvants

(2017) J.-B. Sun et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice

(2016) Liang Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

The nuclear aryl hydocarbon receptor is involved in regulation of DNA repair and cell survival following treatment with ionizing radiation

(2016) K.H. Dittmann et al.   TOXICOLOGY LETTERS

Radiologic Differences between Bone Marrow Stromal and Hematopoietic Progenitor Cell Lines from Fanconi Anemia (Fancd2–/–) Mice

(2014) Hebist Berhane et al.   RADIATION RESEARCH

Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi AnemiaFancd2–/–(FVB/N) Mice by Intraoral GS-Nitroxide JP4-039

(2014) Hebist Berhane et al.   RADIATION RESEARCH

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice

(2014) Brian J. Leibowitz et al.   Nature Communications

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Amelioration of Radiation-Induced Pulmonary Fibrosis by a Water-Soluble Bifunctional Sulfoxide Radiation Mitigator (MMS350)

(2013) Ronny Kalash et al.   RADIATION RESEARCH

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

(2011) Ju Qiu et al.   IMMUNITY

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Sphingosine-1-Phosphate Activates the AKT Pathway to Protect Small Intestines from Radiation-Induced Endothelial Apoptosis

(2010) S. Bonnaud et al.   CANCER RESEARCH

Mitochondrial Targeting of a Catalase Transgene Product by Plasmid Liposomes Increases RadioresistanceIn VitroandIn Vivo

(2009) Michael W. Epperly et al.   RADIATION RESEARCH

Bax and Bak Do Not Exhibit Functional Redundancy in Mediating Radiation-Induced Endothelial Apoptosis in the Intestinal Mucosa

(2008) Jimmy A. Rotolo et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Timing of Lethality From Gastrointestinal Syndrome in Mice Revisited

(2008) Jimmy A. Rotolo et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS