Article
Pharmacology & Pharmacy
Chun-lin Zhang, Hai-ling Wang, Peng-cheng Li, Can-dong Hong, An-qi Chen, Yan-mei Qiu, Ai-ping Zeng, Yi-fan Zhou, Bo Hu, Ya-nan Li
Summary: Research suggests that the failure of DHA therapy in some patients with diabetic retinopathy (DR) is associated with low expression of Mfsd2a, and the combination of Mfsd2a overexpression with DHA therapy may be an effective treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dongjoon Kim, Marcela Votruba, Sayon Roy
Summary: Reduced level of Opa1 promotes apoptosis and retinal vascular lesions associated with diabetic retinopathy. Downregulation of Opa1 expression contributes to the development of retinal cell death and capillary damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Malgorzata Mrugacz, Anna Bryl, Katarzyna Zorena
Summary: Diabetes mellitus is a growing societal issue, with increasing incidence of type 1 and type 2 diabetes. Diabetic retinopathy, caused by vascular abnormalities, involves small vessels and may also result from neuroretinal degeneration. Understanding the factors and mechanisms contributing to these changes is essential in preventing complications in diabetes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Dongjoon Kim, Hiromi Sesaki, Sayon Roy
Summary: The study found that reducing Drp1 levels can decrease diabetes-induced retinal vascular lesions, reduce the number of acellular capillaries and pericyte loss, and is associated with an increase in the expression of apoptosis-related genes.
Article
Biotechnology & Applied Microbiology
Min Tian, Jun Yang, Xia Yan, Yang Cao, Yuting Liu, Yingqing Lei, Hongbin Lv
Summary: This study reveals that inhibiting TUG1 can impair vascular function in diabetic retinas by controlling miR-524-5p and FGFR2, suggesting a potential therapeutic method for diabetic retinopathy.
Article
Biochemistry & Molecular Biology
Devy Deliyanti, Varaporn Suphapimol, Phoebe Ang, Xiuying Tang, Abhirup Jayasimhan, Jennifer L. Wilkinson-Berka
Summary: This study found that the increase of neutrophils contributes to retinal inflammation and vascular injury in oxygen-induced retinopathy. Depletion of neutrophils with anti-Ly6G mAb reduces inflammation and vasculopathy in the retina.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Warren W. Pan, Thomas W. Gardner, Jennifer L. Harder
Summary: DRD remains a common cause of vision loss in working-age adults, with limited progress on new therapies due to the complexity of the human eye. Utilizing systems biology approaches that have been successful in DKD research may help clarify the molecular basis and progression of DRD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Wonjin Park, Joohwan Kim, Seunghwan Choi, Taesam Kim, Minsik Park, Suji Kim, Ji-Chang You, Jeong Hun Kim, Kwon-Soo Ha, Jeong-Hyung Lee, Young-Guen Kwon, Young-Myeong Kim
Summary: The newly developed Ac-RLYE has shown potential therapeutic effects for diabetic retinopathy by antagonizing VEGFR-2, thereby preventing blood-retinal barrier breakdown and vascular leakage while maintaining retinal capillary pericyte coverage.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Rachael S. Allen, Cara T. Khayat, Andrew J. Feola, Alice S. Win, Allison R. Grubman, Kyle C. Chesler, Li He, Jendayi A. Dixon, Timothy S. Kern, P. Michael Iuvone, Peter M. Thule, Machelle T. Pardue
Summary: This study investigated the temporal appearance of functional deficits (retinal, cognitive, and motor), retinal vascular pathology, and retinal dopamine levels in diabetic rats. The results showed that glucose intolerance and retinal deficits were detectable at 4 weeks and 1 month, respectively. Cognitive deficits appeared at 6 months, but no motor deficits were observed. Retinal vascular pathology was not observed, and high levels of dopamine may provide protection against vascular pathology.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ting Xie, Xiaodong Chen, Wenyi Chen, Sien Huang, Xinye Peng, Lingmei Tian, Xuejie Wu, Yan Huang
Summary: The study found that curcumin can significantly reduce blood glucose, relieve oxidative stress, and improve pathological damage in diabetic rats. Curcumin not only significantly reduces retinal edema, but also has a better anti-photoreceptor apoptosis effect than insulin. In the early stages of diabetes, retinal oxidative stress induced the adaptive activation of the nuclear factor E2-associated factor 2 (Nrf2) pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Scott J. Howell, Chieh A. Lee, Julia C. Batoki, Thomas E. Zapadka, Sarah Lindstrom, Brooklyn E. Taylor, Patricia R. Taylor
Summary: The global number of diabetics is increasing annually, leading to a rise in diabetic retinopathy cases. XMD8-92, a small molecule inhibitor, shows potential as a novel therapeutic for diabetic retinopathy by blocking inflammatory processes and reducing retinal inflammation in experimental models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ophthalmology
Jun Chen, Yizhou Sun, Lei Chen, Yun Zhou
Summary: The study found that CBR2 plays a protective role in diabetic retinopathy by regulating VEGFA, alleviating retinal vascular dysfunction and abnormal endothelial proliferation.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Xudong Wang, Tianxi Wang, Enton Lam, David Alvarez, Ye Sun
Summary: The eye has immune privilege to protect retinal neural cells from immune provocation. However, breach of this privilege can lead to acute inflammatory responses and chronic inflammation, causing ocular diseases and vision loss. This review discusses the features of immune privilege in the retina, the inflammatory responses and factors involved when immune privilege fails, as well as recent advances in ocular immunity and ocular vascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Jian Yang, Xiao Miao, Feng-Juan Yang, Jin-Feng Cao, Xin Liu, Jin-Ling Fu, Guan-Fang Su
Summary: Diabetic retinopathy (DR) is a major cause of blindness among working individuals worldwide, with an increasing incidence among younger diabetic patients and a need for lifelong treatment. Current treatment methods have limitations, highlighting the importance of discovering drugs targeting the pathogenesis of DR.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Ophthalmology
Selin L. Auvazian, Jennifer Cano, Sophie Leahy, Preny Karamian, Amir Kashani, Andrew Moshfeghi, Hossein Ameri, Norman P. Blair, Mahnaz Shahidi
Summary: This study aimed to investigate the association of retinal vessel oxygen saturation with vessel density (VD) and tortuosity in diabetic retinopathy (DR). Results from measurements on 95 subjects showed significant differences in oxygen saturation, VD, and vessel tortuosity among different DR groups, suggesting a correlation between retinal vessel morphology, oxygenation, and DR severity.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)