Article
Multidisciplinary Sciences
Xinyi Cao, Jiuchen Wang, Tianye Zhang, Zhiheng Liu, Lijun Liu, Ying Chen, Zehua Li, Youlu Zhao, Qi Yu, Tong Liu, Jing Nie, Yuanjie Niu, Yupeng Chen, Li Yang, Lirong Zhang
Summary: Renal tubular epithelial cells can respond to varying kidney injuries either adaptively or maladaptively. This study elucidates the chromatin-mediated mechanism underlying the responses of renal tubular epithelial cells to different kidney injuries, and identifies RXR alpha as a therapeutic target for acute kidney injury.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Qisheng Lin, Shu Li, Haijiao Jin, Hong Cai, Xuying Zhu, Yuanting Yang, Jingkui Wu, Chaojun Qi, Xinghua Shao, Jialin Li, Kaiqi Zhang, Wenyan Zhou, Minfang Zhang, Jiayi Cheng, Leyi Gu, Shan Mou, Zhaohui Ni
Summary: This study investigated the mechanism by which mitophagy protects against ferroptosis in cisplatin-induced acute kidney injury. The results showed aggravated iron accumulation, lipid peroxidation, and ferroptosis in mice lacking BNIP3, Pink1, or Park2. Additionally, the synthetic antioxidant ferroptosis inhibitor, Ferrstatin-1, rescued the effects of mitophagy inhibition.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yan Li, Ke Li, Weihao Zhao, Haodong Wang, Xiaodong Xue, Xianghui Chen, Wantao Li, Peihao Xu, Kexin Wang, Pengfei Liu, Xuefei Tian, Rongguo Fu
Summary: This study found that valproic acid (VPA) prevents cisplatin-induced renal injury through regulating glutathione peroxidase 4 (GPX4) and inhibiting ferroptosis. This suggests that inhibiting ferroptosis through VPA is a viable treatment for cisplatin-induced acute kidney injury.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Physiology
Peipei Wang, Jing Ouyang, Zhanjun Jia, Aihua Zhang, Yunwen Yang
Summary: The prevalence of renal diseases is increasing globally, yet the pathogenesis and effective treatments are still unclear. DNA damage and the related DNA damage response have been identified as common factors in acute kidney injury (AKI) and chronic kidney disease (CKD). Reactive oxygen species induced DNA damage is a common type involved in the development of these conditions. Recent developments in the field of DNA damage have provided insights into the role of DNA damage and DNA damage response in renal tubular epithelial cell injury. Focusing on DNA damage and DNA damage response may offer valuable diagnostic biomarkers and treatment strategies for renal diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Immunology
Sean E. DeWolf, Sashi G. Kasimsetty, Alana A. Hawkes, Lisa M. Stocks, Sunil M. Kurian, Dianne B. McKay
Summary: This study demonstrates for the first time that endogenous DAMPs released from injured RTECs directly activate PRR signaling in healthy RTECs. These findings provide new insights for the treatment of renal IRI.
Article
Urology & Nephrology
Lirui Wang, Jiangtao Li, Chen Yu
Summary: The study indicated that SENP3 played a significant regulatory role in LPS-induced AKI, inducing cell apoptosis through protein deSUMOylation and exacerbating damage to renal tubular epithelial cells.
Article
Critical Care Medicine
Min Gao, Hongbin Li, Qilong Liu, Ning Ma, Panpan Zi, Huijuan Shi, Yuming Du
Summary: The study found that KLF6 was highly expressed in septic acute kidney injury (SAKI). Knockdown of KLF6 alleviated oxidative stress and pyroptosis in SAKI. Mechanistically, KLF6 inhibited miR-223-3p expression and promoted NLRP3 activation, thereby aggravating SAKI.
Article
Medicine, Research & Experimental
Jiachuan Xiong, Li Ran, Yingguo Zhu, Yaqin Wang, Shaobo Wang, Yue Wang, Qigang Lan, Wenhao Han, Yong Liu, Yinghui Huang, Ting He, Yan Li, Li Liu, Jinghong Zhao, Ke Yang
Summary: The study reveals the important role of the DUSP2-STAT1 axis in regulating RTEC pyroptosis in AKI and highlights it as an attractive therapeutic target for AKI.
Article
Medicine, Research & Experimental
Shuiqin Gong, Aihong Zhang, Mengying Yao, Wang Xin, Xu Guan, Shaozong Qin, Yong Liu, Jiachuan Xiong, Ke Yang, Li Xiong, Ting He, Yinghui Huang, Jinghong Zhao
Summary: Ischemic-reperfusion injury (IRI) is a major factor in acute kidney injury (AKI) that leads to hypoxic injury of renal tubular epithelial cells (RTECs). The upregulation of repressor element 1-silencing transcription factor (REST) in AKI patients, mice, and RTECs is positively correlated with the severity of kidney injury. Knockout of Rest in renal tubules significantly alleviates AKI and its progression to chronic kidney disease (CKD). These findings highlight the involvement of REST in the transition from AKI to CKD and reveal its ferroptosis-inducing effect, suggesting it as a potential therapeutic target for AKI and CKD.
Article
Cell & Tissue Engineering
Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung, Der-Cherng Tarng
Summary: This study demonstrates that the enhancing effect of MSCs, especially HMSCs, on tissue autophagy can be applied to suppress renal tubular apoptosis and attenuate renal impairment during renal I/R injury in rats. These findings provide further mechanistic support for HMSC therapy and its investigation in clinical trials of ischemic AKI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Yan Liang, Zhenjie Liu, Lingyun Qu, Yingzi Wang, Yali Zhou, Lulu Liang, Yanhong Guo, Lin Tang
Summary: The study revealed an interaction between the IRE1/JNK pathway and ferroptosis in ischemia-reperfusion or hypoxia-reoxygenation induced acute kidney injury. Inhibiting the IRE1/JNK pathway has a protective effect on reducing I/R renal injury or AKI, and may serve as a therapeutic target for treating AKI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yinyin Ye, Lingling Xu, Hao Ding, Xiao Wang, Jing Luo, Yu Zhang, Ke Zen, Yi Fang, Chunsun Dai, Yuwei Wang, Yang Zhou, Lei Jiang, Junwei Yang
Summary: PKM2 plays a role in fibroblast activation in AKI, and its loss impairs fibroblast proliferation, promotes tubular epithelial cell death, and may worsen AKI by blocking HGF signal activation. Targeting PKM2 expression could be a novel strategy for treating AKI.
Article
Biochemistry & Molecular Biology
Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Vassilios Liakopoulos, Ioannis Stefanidis
Summary: Inhibition of malate dehydrogenase-2 (MDH-2) protects renal cells from death or senescence caused by ischemia-reperfusion injury. MDH-2 inhibition reduces oxidative stress and inflammation, and maintains cell proliferation capacity.
Review
Nutrition & Dietetics
Leslie S. Gewin
Summary: The kidney relies on specialized epithelial cells in the renal tubules for reabsorption, with the proximal tubules using fatty acid oxidation as the preferred metabolic pathway. After kidney injury, there are alterations in metabolism leading to decreased fatty acid oxidation and increased lactic acid generation.
Article
Critical Care Medicine
Diyu Lv, Ying Zhang, Chunmei Wang, Yi Gu, Yang Zhang, Xiuhua Li
Summary: This study investigates the role of platelet-derived transthyretin (TTR) in sepsis-associated acute kidney injury (S-AKI). The results indicate that platelet TTR can cause oxidative stress and apoptosis in human renal proximal tubule epithelial (HK2) cells, and may play an important role in the development of S-AKI.
Article
Ophthalmology
Jian Hu, Yueyue Li, Qian Li, Liqiang Wang, Yifei Huang
Summary: This retrospective study evaluated the effectiveness of tailored surgical treatment based on the mechanical balance principle in treating involutional entropion in the lower eyelid. It was found that the surgical plans were safe and effective, with no recurrence cases during the follow-up period.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jie Wu, Tengyun Wu, Shuo Zheng, Yifei Huang, Liqiang Wang
Summary: Repeated low-dose exposure to DC on the ocular surface caused significant impairments on the structure and viability of the corneal epithelium by inhibiting epithelial proliferation and inducing apoptosis. This study provides a foundation for understanding the harmful effects of daily exposure to cleaning products on the ocular surface.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Jie Wu, Junyi Wang, Liqiang Wang, Yifei Huang
Summary: This study showed that retinoic acid can increase corneal stiffness by upregulating TG2 expression for crosslinking. Experimental and microscopic results confirmed that retinoic acid increased collagen density in the cornea and increased its elastic modulus.
EXPERIMENTAL EYE RESEARCH
(2022)
Letter
Ophthalmology
Liqiang Wang, Zongyuan Li, Tengyun Wu, Anqi Liu, Xiezhou He, Shuo Zheng, Tao Ye, Liyuan Rong, Yifei Huang
Article
Nanoscience & Nanotechnology
Anqi Liu, Chunjing Liang, Ji Liu, Yifei Huang, Ming Wang, Liqiang Wang
Summary: This study reports the design of a novel ROS-responsive lipid nanoparticle for enhanced RNAi in CNV treatment. The lipid nanoparticles efficiently deliver siRNA into cells and release siRNA in response to the upregulated ROS in CNV.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Integrative & Complementary Medicine
Yumei Zhou, Weiwei Xu, Anqi Liu, Ye Tao, Qun Wang, Yanfeng Yang, Liqiang Wang, Yifei Huang
Summary: Salvianolic acids (Sal A) have a protective effect on retinal degeneration (RD) by antioxidant and antiapoptotic mechanisms, as demonstrated in both in vivo and in vitro experiments.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Ophthalmology
Qing-Hua Yang, Hong-Tao Zhang, Xiao-Qi Li, Bing Chen, Zhao-Hui Li, Yi-Fei Huang, Xin Jin, Ying Zhang, Li-Qiang Wang
Summary: The segmented measurement of axial length by immersion B-scan shows comparable accuracy with that of IOLMaster 500 in ultra-high myopia patients with severe cataract secondary to silicone oil filling, leading to ideal postoperative refractive outcomes.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Liyuan Rong, Yan Fu, Qiyou Li, Xinji Yang, Yueyue Li, Liang Yan, Liqiang Wang, Wei Wu
Summary: In this study, the effect of surface charge of PEG-GO on ocular compatibility was comprehensively investigated through in vitro and in vivo studies. The results showed that the surface charge of PEG-GO had negligible effect on its ocular compatibility, except for the cellular uptake. These findings contribute to our understanding of the relationship between surface charge and biocompatibility of GO derivatives.
Review
Clinical Neurology
Kaixiu Li, Qun Wang, Liqiang Wang, Yifei Huang
Summary: Visual impairment and cognitive impairment are related to high myopia, but the specific pathogenesis and neural structure damage are not well understood.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Zhao Li, Qun Wang, Shi-Feng Zhang, Yi-Fei Huang, Li-Qiang Wang
Summary: The purpose of this study was to summarize and discuss the treatment and timing of glaucoma in patients with MICOF keratoprosthesis implantation. The data analysis showed that patients with preexisting glaucoma were more likely to undergo corneal transplants, while there was a difference in the efficacy between surgical and medical treatment in patients with de novo glaucoma.
FRONTIERS IN MEDICINE
(2022)
Article
Neurosciences
Kaixiu Li, Xiaoqi Li, Qun Wang, Liqiang Wang, Yifei Huang
Summary: This study compared the kinetic pupillary changes between high myopia and low/moderate myopia using Pentacam. The results showed that in certain scanning periods, the pupillary changes in high myopia patients were slower compared to low/moderate myopia patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Zongyuan Li, Kunkun Yang, Yannan Zhou, Tengyun Wu, Hongtao Zhang, Qinghua Yang, Qun Wang, Yifei Huang, Liqiang Wang
Summary: KLAL-DALK is an effective option for restoring a stable ocular surface and rapidly improving visual acuity in patients with bilateral severe LSCD.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Zhicha Hu, Wenqin Xu, Xinji Yang, Yueyue Li, Rui Ma, Yan Hei, Jian Hu, Zifeng Zhang, Liqiang Wang, Yusheng Wang
Summary: Despite extensive research, the exact mechanism of retinopathy of prematurity (ROP) is still unclear. In this study, the role of Sirt2, involved in both angiogenesis and inflammation, was investigated in a ROP animal model. The study found that Sirt2 was overexpressed and co-located with microglia in the model. Additionally, the study demonstrated that Sirt2 levels were upregulated in hypoxic microglia BV-2 in vitro.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Medicine, General & Internal
Zhibang Zhao, Wenliang Fan, Liqiang Wang, Qingbo Chu
Summary: This study aimed to explore the association between lipids and the survival and walking ability of hip fractures in geriatric patients after surgery. Restricted cubic spline was used to establish the nonlinear relationship, and the patients were divided into low, middle, and high levels of LDL-c. The results showed that patients with middle levels of LDL-c had a significantly higher survival probability, and low and high levels of LDL-c were associated with poor prognosis in terms of mortality and free walking ability.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
