Structural Mechanism Underpinning Cross-reactivity of a CD8+T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

(2016) David K. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy

(2016) Marine C C Raman et al.   Scientific Reports

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

(2015) Chihiro Motozono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

(2015) Jarrett J Adams et al.   NATURE IMMUNOLOGY

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

(2015) Henrik N Kløverpris et al.   Retrovirology

Deconstructing the Peptide-MHC Specificity of T Cell Recognition

(2014) Michael E. Birnbaum et al.   CELL

Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides

(2014) Florian Madura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Decision making inxia2

(2013) Graeme Winter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions

(2013) David K. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-cell Receptor Specificity Maintained by Altered Thermodynamics

(2013) Florian Madura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells

(2013) B. J. Cameron et al.   Science Translational Medicine

Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop

(2013) Dhruv K. Sethi et al.   Nature Communications

Cellular-Level Versus Receptor-Level Response Threshold Hierarchies in T-Cell Activation

(2013) Hugo A. van den Berg et al.   Frontiers in Immunology

Peptide length determines the outcome of TCR/peptide-MHCI engagement

(2012) J. Ekeruche-Makinde et al.   BLOOD

Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies

(2012) Milos Aleksic et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TCR/pMHC Optimized Protein crystallization Screen

(2012) Anna M. Bulek et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

(2012) Anna M Bulek et al.   NATURE IMMUNOLOGY

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

Structural and biophysical determinants of αβ T-cell antigen recognition

(2011) John S. Bridgeman et al.   IMMUNOLOGY

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides

(2011) Linda Wooldridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allelic polymorphism in the T cell receptor and its impact on immune responses

(2010) Stephanie Gras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8 Controls T Cell Cross-Reactivity

(2010) L. Wooldridge et al.   JOURNAL OF IMMUNOLOGY

Real time detection of peptide–MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability

(2010) Kim M. Miles et al.   MOLECULAR IMMUNOLOGY

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

(2010) S. R. Burrows et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers

(2008) J. Joseph Melenhorst et al.   JOURNAL OF IMMUNOLOGICAL METHODS

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding

(2008) David K. Cole et al.   MOLECULAR IMMUNOLOGY