Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α

The glucocorticoid receptor: cause of or cure for obesity?

(2016) Kezia John et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity

(2016) Ricardo J. Samms et al.   ENDOCRINOLOGY

FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone

(2016) Lance A. Stechschulte et al.   ENDOCRINOLOGY

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

PPARα (Peroxisome Proliferator-activated Receptor α) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition

(2016) Sadeesh K. Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Decreased expression of the glucocorticoid receptor-GILZ pathway in Kupffer cells promotes liver inflammation in obese mice

(2016) Olivier Robert et al.   JOURNAL OF HEPATOLOGY

Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk

(2016) L. Bozzetto et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

(2016) Gianpaolo Rando et al.   eLife

Bilirubin Binding to PPARα Inhibits Lipid Accumulation

(2016) David E. Stec et al.   PLoS One

Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα

(2015) Michiharu Komatsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepatic insulin resistance and increased hepatic glucose production in mice lackingFgf21

(2015) João Paulo G Camporez et al.   JOURNAL OF ENDOCRINOLOGY

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Human Glucocorticoid Receptor β Regulates Gluconeogenesis and Inflammation in Mouse Liver

(2015) Bo He et al.   MOLECULAR AND CELLULAR BIOLOGY

Glucocorticoids Regulate the Metabolic Hormone FGF21 in a Feed-Forward Loop

(2015) Rucha Patel et al.   MOLECULAR ENDOCRINOLOGY

Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice

(2015) Lei Zhao et al.   Scientific Reports

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Glucocorticoid Receptor β Stimulates Akt1 Growth Pathway by Attenuation of PTEN

(2014) Lance A. Stechschulte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

(2014) Gerald I. Shulman   NEW ENGLAND JOURNAL OF MEDICINE

Role of Innate Immune Response in Non-Alcoholic Fatty Liver Disease: Metabolic Complications and Therapeutic Tools

(2014) Rosaria Meli et al.   Frontiers in Immunology

Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21

(2013) Terry D. Hinds et al.   Obesity

ADP-Stimulated Activation of Akt During Integrin Outside-In Signaling Promotes Platelet Spreading by Inhibiting Glycogen Synthase Kinase-3β

(2012) Kelly A. O’Brien et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolic Syndrome, Insulin Resistance, and Roles of Inflammation – Mechanisms and Therapeutic Targets

(2012) Giulio R. Romeo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL-23 Cytokine Stimulation in Peripheral Mononuclear Cells

(2012) Alejandro Vazquez-Tello et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Evidence for a glucocorticoid receptor beta splice variant in the rat and its physiological regulation in liver

(2012) Debra C. DuBois et al.   STEROIDS

Menin liver-specific hemizygous mice challenged with high fat diet show increased weight gain and markers of metabolic impairment

(2012) L Wuescher et al.   Nutrition & Diabetes

Activation of peroxisome proliferator-activated receptor-α (PPARα) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes

(2011) Rino Kimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Non-alcoholic fatty liver disease

(2011) Briohny W. Smith et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

(2011) Xuan Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-γ (PPARγ)

(2011) Terry D. Hinds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid Cell IL-10 Production in Response to Leishmania Involves Inactivation of Glycogen Synthase Kinase-3  Downstream of Phosphatidylinositol-3 Kinase

(2011) D. Nandan et al.   JOURNAL OF IMMUNOLOGY

PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver

(2011) Mohamed A. Abdelmegeed et al.   JOURNAL OF NUTRITION

Differential regulation of PTEN expression by androgen receptor in prostate and breast cancers

(2011) Y Wang et al.   ONCOGENE

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

(2010) f. M. Fisher et al.   DIABETES

Susceptibility to Diet-Induced Hepatic Steatosis and Glucocorticoid Resistance in FK506-Binding Protein 52-Deficient Mice

(2010) Manya Warrier et al.   ENDOCRINOLOGY

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

(2010) Jody Dushay et al.   GASTROENTEROLOGY

Discovery of Glucocorticoid Receptor-β in Mice with a Role in Metabolism

(2010) Terry D. Hinds et al.   MOLECULAR ENDOCRINOLOGY

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway

(2010) Mary D. L. Chau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity

(2009) Eric D. Berglund et al.   ENDOCRINOLOGY

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

(2009) Michael K. Badman et al.   ENDOCRINOLOGY

Glucocorticoid Receptor in Health and Disease

(2009) Jadranka Dunđerski et al.   Journal of Medical Biochemistry

FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

(2009) M. J. Potthoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

FGF21 attenuates lipolysis in human adipocytes - A possible link to improved insulin sensitivity

(2008) Peter Arner et al.   FEBS LETTERS

Development of Nonalcoholic Steatohepatitis in Insulin-Resistant Liver-Specific S503A Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Mutant Mice

(2008) Sang Jun Lee et al.   GASTROENTEROLOGY