Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

(2016) Sai Krishna Athuluri-Divakar et al.   CELL

Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP

(2016) Yanping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of RAF protein kinases in ERK signalling

(2015) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

(2013) Jiancheng Hu et al.   CELL

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins

(2013) Philippe Riou et al.   CELL

Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation

(2013) Yanping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase A-dependent Phosphorylation of Rap1 Regulates Its Membrane Localization and Cell Migration

(2013) Maho Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras and Rap1 govern spatiotemporal dynamic of activated ERK in pituitary living cells

(2012) Caroline Zeiller et al.   CELLULAR SIGNALLING

Kinase Suppressor of Ras 2 (KSR2) Regulates Tumor Cell Transformation via AMPK

(2012) M. R. Fernandez et al.   MOLECULAR AND CELLULAR BIOLOGY

RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling

(2011) Melissa M. McKay et al.   CURRENT BIOLOGY

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

(2011) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of membranous adenylyl cyclases

(2011) Roland Seifert et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

RAF protein-serine/threonine kinases: Structure and regulation

(2010) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Interaction of Epac1 and Ran Promotes Rap1 Activation at the Nuclear Envelope

(2010) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

(2010) F. Donelson Smith et al.   NATURE CELL BIOLOGY

Phosphorylation-induced Conformational Changes in Rap1b

(2009) Martin M. Edreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase A and B-Raf Mediate Extracellular Signal-Regulated Kinase Activation by Thyrotropin

(2009) L. A. Vuchak et al.   MOLECULAR PHARMACOLOGY

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2

(2009) Kristof Van Kolen et al.   NEUROPHARMACOLOGY

Signaling dynamics of the KSR1 scaffold complex

(2009) M. M. McKay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Functional Interaction of 14-3-3 Proteins with the ERK1/2 Scaffold KSR1 Occurs in an Isoform-specific Manner

(2008) Lucas R. Jagemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2

(2008) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY