Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells

(2013) Tara J. Dillon et al.   INTERNATIONAL IMMUNOLOGY

Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells

(2013) A. C. Emery et al.   Science Signaling

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

The Helicase HAGE Expressed by Malignant Melanoma-Initiating Cells Is Required for Tumor Cell Proliferationin Vivo

(2012) Adam J. Linley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling

(2011) Melissa M. McKay et al.   CURRENT BIOLOGY

Cancer therapy based on oncogene addiction

(2011) Frank McCormick   JOURNAL OF SURGICAL ONCOLOGY

ERK and PDE4 cooperate to induce RAF isoform switching in melanoma

(2011) Amélie Marquette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting the RAS pathway in melanoma

(2011) Zhenyu Ji et al.   TRENDS IN MOLECULAR MEDICINE

RAF protein-serine/threonine kinases: Structure and regulation

(2010) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pin1 expression contributes to lung cancer prognosis and carcinogenesis

(2010) Xiaogang Tan et al.   CANCER BIOLOGY & THERAPY

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Oncogenic K-ras “addiction” and synthetic lethality

(2010) Anurag Singh et al.   CELL CYCLE

The Interaction of Epac1 and Ran Promotes Rap1 Activation at the Nuclear Envelope

(2010) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade

(2010) F. Donelson Smith et al.   NATURE CELL BIOLOGY

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades

(2009) Jun Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades

(2009) Uma Kant Misra et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling

(2009) D. A. Ritt et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Kinase A and B-Raf Mediate Extracellular Signal-Regulated Kinase Activation by Thyrotropin

(2009) L. A. Vuchak et al.   MOLECULAR PHARMACOLOGY

Combined Targeting of BRAF and CRAF or BRAF and PI3K Effector Pathways Is Required for Efficacy in NRAS Mutant Tumors

(2009) Bijay S. Jaiswal et al.   PLoS One

Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2

(2008) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

(2008) Kevin M Haigis et al.   NATURE GENETICS