Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies

Binding Rate Constants Reveal Distinct Features of Disordered Protein Domains

(2015) Jakob Dogan et al.   BIOCHEMISTRY

Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding

(2015) Munehito Arai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Demonstration of a Folding after Binding Mechanism in the Recognition between the Measles Virus NTAIL and X Domains

(2014) Marion Dosnon et al.   ACS Chemical Biology

Helical Propensity in an Intrinsically Disordered Protein Accelerates Ligand Binding

(2014) Vytautas Iešmantavičius et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Distinguishing induced fit from conformational selection

(2014) Stefano Gianni et al.   BIOPHYSICAL CHEMISTRY

Conformational Recognition of an Intrinsically Disordered Protein

(2014) James M. Krieger et al.   BIOPHYSICAL JOURNAL

Only Kinetics Can Prove Conformational Selection

(2014) Jakob Dogan et al.   BIOPHYSICAL JOURNAL

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Coupled Folding and Binding of the Disordered Protein PUMA Does Not Require Particular Residual Structure

(2014) Joseph M. Rogers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells

(2014) Wade Borcherds et al.   Nature Chemical Biology

Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein

(2014) J. M. Rogers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperature-dependent solvation modulates the dimensions of disordered proteins

(2014) R. Wuttke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery within a transcription coactivator is predominantly mediated through dissociation rate constants

(2014) S. L. Shammas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prepaying the entropic cost for allosteric regulation in KIX

(2014) S. M. Law et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule spectroscopy reveals polymer effects of disordered proteins in crowded environments

(2014) Andrea Soranno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanism of binding of the KIX domain to the mixed lineage leukemia protein and its allosteric role in the recognition of c-Myb

(2014) Angelo Toto et al.   PROTEIN SCIENCE

Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core

(2013) Sven Brüschweiler et al.   ACS Chemical Biology

Describing intrinsically disordered proteins at atomic resolution by NMR

(2013) Malene Ringkjøbing Jensen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mechanism of Assembly of the Non-Covalent Spectrin Tetramerization Domain from Intrinsically Disordered Partners

(2013) Stephanie A. Hill et al.   JOURNAL OF MOLECULAR BIOLOGY

Remarkably Fast Coupled Folding and Binding of the Intrinsically Disordered Transactivation Domain of cMyb to CBP KIX

(2013) Sarah L. Shammas et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Folding and Binding of an Intrinsically Disordered Protein: Fast, but Not ‘Diffusion-Limited’

(2013) Joseph M. Rogers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular recognition by the KIX domain and its role in gene regulation

(2013) J. K. Thakur et al.   NUCLEIC ACIDS RESEARCH

Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system

(2013) R. Giri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

(2013) R. K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Sequence and Forces to Structure, Function, and Evolution of Intrinsically Disordered Proteins

(2013) Julie D. Forman-Kay et al.   STRUCTURE

The transition state structure for coupled binding and folding of disordered protein domains

(2013) Jakob Dogan et al.   Scientific Reports

A folding-after-binding mechanism describes the recognition between the transactivation domain of c-Myb and the KIX domain of the CREB-binding protein

(2012) Stefano Gianni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Conformational Selection or Induced Fit? A Critical Appraisal of the Kinetic Mechanism

(2012) Austin D. Vogt et al.   BIOCHEMISTRY

Slow, Reversible, Coupled Folding and Binding of the Spectrin Tetramerization Domain

(2012) S.L. Shammas et al.   BIOPHYSICAL JOURNAL

Dynamics and mechanisms of coupled protein folding and binding reactions

(2012) Thomas Kiefhaber et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Fast Association and Slow Transitions in the Interaction between Two Intrinsically Disordered Protein Domains

(2012) Jakob Dogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantifying internal friction in unfolded and intrinsically disordered proteins with single-molecule spectroscopy

(2012) A. Soranno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy

(2012) H. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constructing ensembles for intrinsically disordered proteins

(2011) Charles K Fisher et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mapping backbone and side-chain interactions in the transition state of a coupled protein folding and binding reaction

(2011) A. Bachmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Affinity, Avidity, and Kinetics of Target Sequence Binding to LC8 Dynein Light Chain Isoforms

(2010) László Radnai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge interactions can dominate the dimensions of intrinsically disordered proteins

(2010) S. Muller-Spath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic Advantage of Intrinsically Disordered Proteins in Coupled Folding–Binding Process: A Critical Assessment of the “Fly-Casting” Mechanism

(2009) Yongqi Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Toward a Unified Representation of Protein Structural Dynamics in Solution

(2009) Phineus R. L. Markwick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational selection or induced fit: A flux description of reaction mechanism

(2009) G. G. Hammes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

(2008) M. Wells et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA