期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 22, 期 1, 页码 21-29出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2011.09.010
关键词
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资金
- Munich Center for Integrative Protein Science (CIPSM)
Protein folding coupled to binding of a specific ligand is frequently observed in biological processes. In recent years numerous studies have addressed the structural properties of the unfolded proteins in the absence of their ligands. Surprisingly few time-resolved investigations on coupled folding and binding reactions have been published up to date and the dynamics and kinetic mechanisms of these processes are still only poorly understood. Especially, it is still unsolved for most systems which conformation of the protein is recognized by the ligand (conformational selection vs. folding-after-binding) and whether the ligand influences the folding kinetics. Here we review experimental methods, kinetic models and time-resolved experimental studies of coupled folding and binding reactions.
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