Enhanced Cytosolic Ca2+Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

(2016) Xiao-Chen Bai et al.   CELL RESEARCH

Non- -blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure

(2015) J. Zhang et al.   BIOCHEMICAL JOURNAL

Roles of the NH2-terminal Domains of Cardiac Ryanodine Receptor in Ca2+Release Activation and Termination

(2015) Yingjie Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ryanodine Receptors: Allosteric Ion Channel Giants

(2015) Filip Van Petegem   JOURNAL OF MOLECULAR BIOLOGY

A novel RyR2 mutation in a 2-year-old baby presenting with atrial fibrillation, atrial flutter, and atrial ectopic tachycardia

(2014) Alfredo Di Pino et al.   HEART RHYTHM

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

(2014) Zhen Yan et al.   NATURE

Abnormal Termination of Ca 2+ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

(2012) Yijun Tang et al.   CIRCULATION RESEARCH

Ligand-dependent Conformational Changes in the Clamp Region of the Cardiac Ryanodine Receptor

(2012) Xixi Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular calcium dynamics in a whole-cell model of an atrial myocyte

(2012) R. Thul et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Mutation in the RYR2 Gene Leading to Catecholaminergic Polymorphic Ventricular Tachycardia and Paroxysmal Atrial Fibrillation: Dose-Dependent Arrhythmia-Event Suppression by β-Blocker Therapy

(2011) Pedram Kazemian et al.   CANADIAN JOURNAL OF CARDIOLOGY

Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis

(2011) Silvia G. Priori et al.   CIRCULATION RESEARCH

Arrhythmia characterization and long-term outcomes in catecholaminergic polymorphic ventricular tachycardia

(2011) Raymond W. Sy et al.   HEART RHYTHM

Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release

(2011) Qiang Zhou et al.   NATURE MEDICINE

Mechanistic models for muscle diseases and disorders originating in the sarcoplasmic reticulum

(2010) David H. MacLennan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Systematic Assessment of Patients With Unexplained Cardiac Arrest

(2009) Andrew D. Krahn et al.   CIRCULATION

Endoplasmic reticulum Ca2+measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+release

(2008) Peter P. Jones et al.   BIOCHEMICAL JOURNAL

Sudden Death in a Young Man with Catecholaminergic Polymorphic Ventricular Tachycardia and Paroxysmal Atrial Fibrillation

(2008) STEPHEN PIZZALE et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY