Disrupting the Allosteric Interaction between thePlasmodium falciparumcAMP-dependent Kinase and Its Regulatory Subunit

Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of eighth biannual meeting (September 2015)

(2016)   MALARIA JOURNAL

Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation

(2016) Melissa J. Buskes et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of Potent Phosphodiesterase Inhibitors that Demonstrate Cyclic Nucleotide-Dependent Functions in Apicomplexan Parasites

(2015) Brittany L. Howard et al.   ACS Chemical Biology

Fitting two- and three-site binding models to isothermal titration calorimetric data

(2015) Chad A. Brautigam   METHODS

Extensive differential protein phosphorylation as intraerythrocyticPlasmodium falciparumschizonts develop into extracellular invasive merozoites

(2015) Edwin Lasonder et al.   PROTEOMICS

Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα

(2015) Madoka Akimoto et al.   PLOS BIOLOGY

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission

(2015) Ghania Ramdani et al.   PLoS Pathogens

The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human Erythrocytes

(2014) Amrita Dawn et al.   PLoS Pathogens

Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs

(2013) Simon H. J. Brown et al.   ACS Chemical Biology

The Algal Past and Parasite Present of the Apicoplast

(2013) Giel G. van Dooren et al.   Annual Review of Microbiology

Evolutionary Paths of the cAMP-Dependent Protein Kinase (PKA) Catalytic Subunits

(2013) Kristoffer Søberg et al.   PLoS One

Signaling through dynamic linkers as revealed by PKA

(2013) M. Akimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease

(2013) Jessica G.H. Bruystens et al.   STRUCTURE

Plasmodiumkinases as targets for new-generation antimalarials

(2012) Isabelle S Lucet et al.   Future Medicinal Chemistry

The Plasmodium falciparum Schizont Phosphoproteome Reveals Extensive Phosphatidylinositol and cAMP-Protein Kinase A Signaling

(2012) Edwin Lasonder et al.   JOURNAL OF PROTEOME RESEARCH

Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target

(2012) Nina M. Haste et al.   MICROBES AND INFECTION

The role of cGMP signalling in regulating life cycle progression of Plasmodium

(2012) Christine S. Hopp et al.   MICROBES AND INFECTION

Localization and quaternary structure of the PKA RI  holoenzyme

(2012) R. Ilouz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Allostery of the PKA RII  Tetrameric Holoenzyme

(2012) P. Zhang et al.   SCIENCE

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

(2011) Lev Solyakov et al.   Nature Communications

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design

(2010) Suguna Badireddy et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure of Yeast Regulatory Subunit: A Glimpse into the Evolution of PKA Signaling

(2010) Jimena Rinaldi et al.   STRUCTURE

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

(2010) Kerstin Leykauf et al.   PLoS Pathogens

Plasmodium falciparum Regulatory Subunit of cAMP-Dependent PKA and Anion Channel Conductance

(2008) Anaïs Merckx et al.   PLoS Pathogens