Article
Pharmacology & Pharmacy
Fabiana Troisi, Simona Pace, Paul M. Jordan, Katharina P. L. Meyer, Rossella Bilancia, Armando Ialenti, Francesca Borrelli, Antonietta Rossi, Lidia Sautebin, Charles N. Serhan, Oliver Werz
Summary: Sex differences and the role of sex hormones in lipid mediator biosynthetic networks were observed in acute self-resolving inflammation in mice, indicating advantages in males controlled by androgens.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Patrick Schaedel, Mareike Wichmann-Costaganna, Anna Czapka, Nadja Gebert, Alessandro Ori, Oliver Werz
Summary: Aging is accompanied by changes in the inflammatory microenvironment, which are tightly regulated by a complex network of inflammatory mediators. Excessive calorie consumption contributes to age-related diseases, while limited nutrient availability may lead to systemic health-promoting adaptations. Short-term caloric restriction (CR) has geroprotective effects on the liver of aged mice, altering the release of immunomodulatory mediators and shifting the production of lipid mediators towards those with inflammation-resolving features.
Article
Immunology
Laura Miek, Paul M. Jordan, Kerstin Guenther, Simona Pace, Timo Beyer, David Kowalak, Verena Hoerr, Bettina Loeffler, Lorena Tuchscherr, Charles N. Serhan, Jana Gerstmeier, Oliver Werz
Summary: The study reveals that S. aureus infection can modulate lipid mediator pathways involved in inflammatory processes, resulting in a shift from anti-inflammatory M2-like signature profiles to pro-inflammatory M1-like signature profiles.
Article
Biochemistry & Molecular Biology
Guanying (Bianca) Xu, Yuan-Xiang Pan, Wenyan Mei, Hong Chen
Summary: This study reveals the critical cellular function of colonic tuft cells in promoting type-2 immune responses by communicating with ILC2s via the L1CAM-integrins interaction. This communication leads to increased secretion of inflammatory cytokines in ILC2s.
Article
Chemistry, Multidisciplinary
Friedemann Boerner, Simona Pace, Paul M. Jordan, Jana Gerstmeier, Mario Gomez, Antonietta Rossi, Nathaniel C. Gilbert, Marcia E. Newcomer, Oliver Werz
Summary: This study reveals that 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) can activate cellular 15-LOX-1 and promote the formation of specialized pro-resolving mediators (SPM) for inflammation resolution. AKBA-induced LOX activation is independent of calcium and phosphorylation, with modest induction of 5-LOX products. The docking of AKBA with the R98 site of 15-LOX-1 is essential for its allosteric activation.
Article
Pharmacology & Pharmacy
Ting Zhou, Shihan Zhang, Yingli Zhou, Simin Lai, Yanjiong Chen, Yan Geng, Jing Wang
Summary: Recent studies have shown that PGRN deficiency exacerbates psoriatic skin lesions, while treatment with curcumin can alleviate the deterioration caused by PGRN deficiency in psoriatic skin lesions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Richard Anderson, Anchal Agarwal, Arnab Ghosh, Bo-Jhih Guan, Jackson Casteel, Nina Dvorina, William M. Baldwin, Barsanjit Mazumder, Taras Y. Nazarko, William C. Merrick, David A. Buchner, Maria Hatzoglou, Roman Kondratov, Anton A. Komar
Summary: eIF2A plays a crucial role in cellular development and stress response, and its knockout results in reduced lifespan, disrupted lipid homeostasis, decreased abundance of immune cells, and potentially affects sex-specific pathways. The identification of eIF2A function in the development of metabolic syndrome holds promise for further insights into specific eIF2A targets responsible for these changes.
Article
Biochemistry & Molecular Biology
Sumiyo Morita, Takuro Horii, Mika Kimura, Ryosuke Kobayashi, Hiroki Tanaka, Hidetaka Akita, Izuho Hatada
Summary: Knockout mice are important tools for studying the normal function of genes. Liver-specific conditional knockout mice can be generated using lipid nanoparticles, which offers a more convenient method compared to traditional approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Lilli Arndt, Ileana Hernandez-Resendiz, Doreen Moos, Janine Dokas, Silvana Mueller, Franziska Jeromin, Richard Wagner, Uta Ceglarek, Iris M. Heid, Marcus Hoering, Gerhard Liebisch, Sonja C. Stadler, Ralph Burkhardt
Summary: This study demonstrates that deficiency of Trib1 promotes the formation of atherosclerotic lesions and increases plasma cholesterol and triglyceride levels in Ldlr(-/-) mice. It also suggests that Trib1 deficiency alters hepatic lipid metabolism and induces inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chang Ho Yoon, Jin Suk Ryu, Jung Hwa Ko, Yeon Kyung Kim, Jang-Hee Oh, Jin Ho Chung, Joo Youn Oh
Summary: The study revealed the impact of Fut1 gene knockout on meibomian glands, showing that Fut1 KO mice had smaller total and acinar areas in comparison to WT mice, decreased meibocyte differentiation, lipid synthesis, and increased inflammation and oxidative stress levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tran Thi Van Anh, Alilou Mostafa, Zhigang Rao, Simona Pace, Stefan Schwaiger, Christian Kretzer, Veronika Temml, Carsten Giesel, Paul M. Jordan, Rossella Bilancia, Christina Weinigel, Silke Rummler, Birgit Waltenberger, Tran Hung, Antonietta Rossi, Hermann Stuppner, Oliver Werz, Andreas Koeberle
Summary: The study identified a potential drug candidate from Vietnamese medicinal plant extracts to alleviate chronic inflammation by targeting 5-lipoxygenase and switching the lipid mediator profile. This candidate showed promising activity in inhibiting leukotriene production and inducing specialized pro-resolving mediators, offering a new strategy to address chronic inflammatory conditions.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Environmental Sciences
Xiqin Lin, Yudong Xu, Tong Tong, Jingjing Zhang, Haotian He, Lingling Yang, Ping Deng, Zhengping Yu, Huifeng Pi, Huihui Hong, Zhou Zhou
Summary: This study assessed the cardiotoxicity of cadmium (Cd) exposure and explored the mechanisms by which Cd exerts its toxic effects. The results showed that Cd exposure induced cardiac injury in mice, as evidenced by histopathological changes, elevated levels of cardiac enzyme markers, and up-regulation of pro-apoptotic genes. Non-targeted lipidomic analysis revealed alterations in cardiac lipid metabolism and an increase in pro-inflammatory lipids after Cd exposure. Furthermore, Cd exposure activated the NF-KB signaling pathway and led to cardiac inflammation. These findings expand our understanding of Cd cardiotoxicity and its association with cardiovascular diseases.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biology
Xue Liu, Ahmed Elagamy Mohamed Mahmoud Khalil, Uthayakumar Muthukumarasamy, Yasuhiro Onogi, Xiaocheng Yan, Inderjeet Singh, Elena Lopez-Gonzales, Andreas Israel, Alberto Cebrian Serrano, Till Strowig, Siegfried Ussar
Summary: Moderate telomere shortening improves insulin sensitivity and glucose tolerance in aged mice by reducing intestinal lipid absorption and altering gut microbiota composition.
Article
Biochemistry & Molecular Biology
Zhendi Wang, Yongyong Hou, Suping Ren, Zhiyuan Liu, Zhuo Zuo, Sicui Huang, Wanqi Wang, Huihui Wang, Yanyan Chen, Yuanyuan Xu, Masayuki Yamamoto, Qiang Zhang, Jingqi Fu, Jingbo Pi
Summary: NFE2L1 plays a crucial role in regulating adipose inflammation and metabolism, impacting fat cell hypertrophy and macrophage infiltration. Knockout of Nfe2l1 leads to reduced lipolytic gene expression, while treatment with CL316243 can alleviate adipose inflammation and related gene expression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Quancheng Cheng, Junwei Zhang, Huiru Ding, Ziyuan Wang, Jinyu Fang, Xuan Fang, Man Li, Rui Li, Jieyi Meng, Huaicun Liu, Xin Lu, Yiyao Xu, Chunhua Chen, Weiguang Zhang
Summary: Aquaporin 9 (AQP9) is a crucial channel for the entry of blood glycerol into the liver, and it plays important roles in regulating osmotic pressure and energy metabolism. Previous studies have shown that AQP9 is involved in the development of various liver diseases. In this study, Aqp9 knockout mice were used to investigate the molecular effects of AQP9 expression on liver tissue. The knockout of Aqp9 affected glycerol metabolism, leading to reduced body weight, hepatocyte death, inflammatory cell infiltration, and immune and inflammatory responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)