Article
Cell Biology
Carla P. Barragan-Alvarez, Eduardo Padilla-Camberos, Nestor F. Diaz, Agustin Cota-Coronado, Claudia Hernandez-Jimenez, Carlos C. Bravo-Reyna, Nestor E. Diaz-Martinez
Summary: ZnT8 plays a crucial role in zinc homeostasis inside pancreatic beta cells and is linked to the stabilization of insulin hexameric form. Studies have shown dual and controversial effects of ZnT8 variants on the risk of developing type 2 diabetes mellitus.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Xiaofan Jia, Ling He, Dongmei Miao, Kathleen Waugh, Cristy Geno Rasmussen, Fran Dong, Andrea K. Steck, Marian Rewers, Liping Yu
Summary: The study indicates that high-affinity ZnT8A detected by ECL has a higher predictive ability for T1D development, with a higher positive predictive value compared to ZnT8A detected by RBA.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Qing Ma, Yini Xiao, Wenjun Xu, Menghan Wang, Sheng Li, Zhihao Yang, Minglu Xu, Tengjiao Zhang, Zhen-Ning Zhang, Rui Hu, Qiang Su, Fei Yuan, Tinghui Xiao, Xuan Wang, Qing He, Jiaxu Zhao, Zheng-jun Chen, Zhejin Sheng, Mengyao Chai, Hong Wang, Weiyang Shi, Qiaolin Deng, Xin Cheng, Weida Li
Summary: Immature function and fragility of hESC-derived beta cells hinder their application for diabetes cell therapy. By targeting the ZnT8 gene, the authors show that loss of function mutations can enhance insulin secretion and cell survival in SC-beta cells, improving their potential use in cell replacement therapies.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Jinjoo Lee, Seungjin Noh, Suhyun Lim, Bonglee Kim
Summary: Type 2 diabetes mellitus is a major global public health issue, with plant extracts being a potential therapeutic agent due to their antidiabetic effects and fewer side effects. These extracts regulate blood glucose, possess anti-inflammatory and antioxidant properties, and can alleviate complications caused by insulin resistance through various pathways.
Article
Immunology
Yong Gu, Chengfeng Merriman, Zheng Guo, Xiaofan Jia, Janet Wenzlau, Hua Li, Huilin Li, Marian Rewers, Liping Yu, Dax Fu
Summary: Type 1 diabetes is characterized by autoimmune destruction of insulin-producing β-cells, and a new autoantibody directed to ZnT8 extracellular epitopes has been identified in newly diagnosed patients. This autoantibody, ZnT8ecA, was the earliest to appear in children with T1D development, suggesting a potential role in the initiation of β-cell autoimmunity.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Xuejiao Zhang, Ying Dong, Dianyuan Liu, Liu Yang, Jiayi Xu, Qing Wang
Summary: Type 1 diabetes mellitus is an autoimmune disease caused by the destruction of pancreatic beta cells. Immune regulation with pancreatic islet auto-antigens is a specific and safe treatment for T1DM. Early screening of autoantibodies can help identify high-risk individuals and prevent T1DM. Inducing self-tolerance in pre-diabetic patients can also slow down autoimmunity and achieve secondary prevention.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Medicine, General & Internal
Opeyemi Soremekun, Ville Karhunen, Yiyan He, Skanda Rajasundaram, Bowen Liu, Apostolos Gkatzionis, Chisom Soremekun, Brenda Udosen, Hanan Musa, Sarah Silva, Christopher Kintu, Richard Mayanja, Mariam Nakabuye, Tafadzwa Machipisa, Amy Mason, Marijana Vujkovic, Verena Zuber, Mahmoud Soliman, Joseph Mugisha, Oyekanmi Nash, Pontiano Kaleebu, Moffat Nyirenda, Tinashe Chikowore, Dorothea Nitsch, Stephen Burgess, Dipender Gill, Segun Fatumo
Summary: This study used Mendelian Randomization to investigate the causal effect of lipid traits on the susceptibility to type 2 diabetes mellitus (T2DM) in individuals of African ancestry. The results showed that increased levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were associated with increased T2DM liability, while increased levels of high-density lipoprotein cholesterol (HDL-C) were associated with reduced T2DM liability. The study also found that inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), a lipid-lowering drug target, was associated with increased T2DM liability.
Article
Medicine, Research & Experimental
Ishant Khurana, Harikrishnan Kaipananickal, Scott Maxwell, Sorine Birkelund, Anna Syreeni, Carol Forsblom, Jun Okabe, Mark Ziemann, Antony Kaspi, Haloom Rafehi, Anne Jorgensen, Keith Al-Hasani, Merlin C. Thomas, Guozhi Jiang, Andrea O. Y. Luk, Heung Man Lee, Yu Huang, Yotsapon Thewjitcharoen, Soontaree Nakasatien, Thep Himathongkam, Christopher Fogarty, Rachel Njeim, Assaad Eid, Tine Willum Hansen, Nete Tofte, Evy C. Ottesen, Ronald C. W. Ma, Juliana C. N. Chan, Mark E. Cooper, Peter Rossing, Per-Henrik Groop, Assam El-Osta
Summary: Diabetic nephropathy (DN) is a polygenic disorder with poorly defined genome-wide methylation patterns. Methylation sequencing using leukocytes from a Finnish diabetes study identified differentially methylated genes associated with DN, which were further validated in independent T1D registries from Denmark, Hong Kong, and Thailand. Reduced DNA methylation at certain sites was connected with DN pathways related to insulin signaling, lipid metabolism, and fibrosis. Experimental observations in human renal cells, macrophages, and vascular endothelial cells supported the findings.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Nasser Laouali, Conor-James MacDonald, Sanam Shah, Douae El Fatouhi, Francesca Romana Mancini, Guy Fagherazzi, Marie-Christine Boutron-Ruault
Summary: The study found that a lower dietary copper/zinc ratio is associated with a lower risk of type 2 diabetes, especially among obese women and women with zinc intake >8 mg/day.
Review
Nutrition & Dietetics
Laura M. Pompano, Erick Boy
Summary: The study compared the effects of low-dose and long-duration zinc interventions on risk factors for T2D and CVD, finding that these interventions were more beneficial than high-dose and short-duration interventions, with effect sizes being equal or greater.
ADVANCES IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
Basak Ozaslan, Sunil Deshpande, Francis J. Doyle III, Eyal Dassau
Summary: This paper explores the method of blood glucose control during pregnancy. By customizing a zone model predictive controller (zone-MPC) and adjusting the control strategy according to clinical needs, the research conducts extensive simulation experiments and achieves good blood glucose control outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Physical
Hiroto Mogi, Kosaku Kato, Shuhei Yasuda, Tomoki Kanazawa, Akinobu Miyoshi, Shunta Nishioka, Takayoshi Oshima, Ya Tang, Toshiyuki Yokoi, Shunsuke Nozawa, Akira Yamakata, Kazuhiko Maeda
Summary: By controlling the quality of the template, the structural properties of the resulting oxynitride can be altered, ultimately affecting photocatalytic activity. Using a template with higher crystallinity leads to the formation of larger oxynitride particles and enhances photocatalytic activity.
CHEMISTRY OF MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Laidy M. Alvero-Gonzalez, D. Aurora Perini, Maria Queralt-Martin, Alex Peralvarez-Marin, Clara Vinas, Antonio Alcaraz
Summary: DynA is an endogenous neuropeptide that has non-opioid pathophysiological properties and can induce cell permeability similar to cell-penetrating peptides. The interaction of DynA with cellular membrane is modulated by lipid charge distribution, enabling passive ionic transport via membrane remodeling and pore formation, as well as peptide direct internalization independent of cellular transduction pathways.
BIOELECTROCHEMISTRY
(2023)
Article
Medicine, General & Internal
Yusuke Mineoka, Michiyo Ishii, Yoshitaka Hashimoto, Aki Yamashita, Takahiro Takemura, Sachiyo Yamaguchi, Machiko Toyoda, Michiaki Fukui
Summary: Our study found a significant relationship between nutritional status and foot risk in patients with type 2 diabetes, especially in older patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Guotai Sheng, Maobin Kuang, Ruijuan Yang, Yanjia Zhong, Shuhua Zhang, Yang Zou
Summary: Both conventional and unconventional lipid parameters are associated with diabetes risk, but unconventional lipid parameters have better predictive value for future diabetes risk.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Physical
Haixin Zhao, Jia Huang, Lulu Huang, Yuqi Yang, Zuoxiu Xiao, Qiaohui Chen, Qiong Huang, Kelong Ai
Summary: Due to the high incidence of kidney disease, there is an urgent need to develop wearable artificial kidneys, especially during the COVID-19 pandemic. However, the current dialysate regeneration system has limitations in removing urea. Therefore, nanomaterials, such as MoS2/CeO2, have been investigated for their potential in effectively adsorbing uremic toxins and regenerating dialysate.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Cell Biology
Roy Anindya, Guy A. Rutter, Gargi Meur
Summary: In this article, the dynamic interaction between pancreatic beta cells, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the host immune system in new-onset type 1 diabetes (T1D) is detailed. It is shown that beta cells express the necessary receptors for SARS-CoV-2 entry and can be infected. However, beta cell expansion and regeneration may effectively compensate for lost beta cells. The appearance of islet autoantibodies following SARS-CoV-2 infection suggests a breakdown of immune tolerance, but many cases also indicate a progression of pre-existing diabetes rather than new-onset T1D.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Parizad Avari, Pei Chia Eng, Ming Hu, Runzhi Chen, Natalija Popovic, Constantin Polychronakos, Duncan Spalding, Guy A. Rutter, Nick Oliver, Florian Wernig
Summary: This article reports a case of a proinsulinoma with suppressed insulin and C-peptide levels. It suggests that low insulin and C-peptide levels do not always indicate the absence of a neuroendocrine islet cell tumor, and elevated proinsulin levels may be an indicator for diagnosis.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Guy A. Rutter, Vaibhav Sidarala, Brett A. Kaufman, Scott A. Soleimanpour
Summary: The regulation of glucose-regulated insulin secretion in diabetes is defective. This review focuses on the role of glucose's privileged oxidative metabolism in glucose detection, the regulation of mitochondrial metabolism by Ca2+, and the importance of mitochondrial structure and dynamics in beta cells. Additionally, it highlights the contributions of Professor Randle and his colleagues towards our understanding of insulin secretion regulation.
BIOCHEMICAL JOURNAL
(2023)
Article
Endocrinology & Metabolism
Jiannan Xiao, Liliane El Eid, Teresa Buenaventura, Raphael Boutry, Amelie Bonnefond, Ben Jones, Guy A. Rutter, Philippe Froguel, Alejandra Tomas
Summary: This study aimed to determine the kinase activity profiles of human pancreatic beta cells downstream of glucagon-like peptide-1 receptor (GLP-1R) balanced versus biased agonist stimulations. The results showed that acute and sustained GLP-1R agonist exposure had distinct effects on kinase responses, and different biased agonists could modulate distinct kinase interaction networks. These findings have important implications for the selection of appropriate anti-type 2 diabetes therapies.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Pauline Chabosseau, Fiona Yong, Luis F. Delgadillo-Silva, Eun Young Lee, Rana Melhem, Shiying Li, Nidhi Gandhi, Jules Wastin, Livia Lopez Noriega, Isabelle Leclerc, Yusuf Ali, Jing W. Hughes, Robert Sladek, Aida Martinez-Sanchez, Guy A. Rutter
Summary: Spatially-organized increases in Ca2+ within pancreatic beta cells under high glucose stimulation were found to be mediated by leader cells, which possess unique molecular features and localized signaling with delta cells. Single cell RNA sequencing revealed differential gene expression related to cilium biogenesis and transcriptional regulation between leader and follower cells.
Article
Multidisciplinary Sciences
Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Aysim Gunes, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Akerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Soren Brunak, Marko Barovic, Gerard A. Bouland, Frederic Burdet, Mickael Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M't Hart, Ewan R. Pearson, Guy A. Rutter
Summary: We identified biomarkers for disease progression in type 2 diabetes cohorts, including metabolites, lipids, and proteins. Various substances such as homocitrulline, isoleucine, 2-aminoadipic acid, triacylglycerol species, and sphingomyelin 42:2;2 levels were found to predict faster progression towards insulin requirement. Proteins like GDF15/MIC-1, IL-18Ra, CRELD1, NogoR, FAS, and ENPP7 were associated with faster progression, while others like SMAC/DIABLO, SPOCK1, and HEMK2 predicted slower progression rates. The findings also suggested possible disease mechanisms and potential therapeutic avenues to slow diabetes progression.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
M. V. Surekha, N. Suneetha, N. Balakrishna, Uday Kumar Putcha, K. Satyanarayana, J. J. Babu Geddam, Pagidoju Sreenu, B. Tulja, Raja Sriswan Mamidi, Guy A. Rutter, Gargi Meur
Summary: This study found that asymptomatic SARS-CoV-2 infection during pregnancy appears to be associated with various abnormal placental histopathologic changes related to placental hypoxia, independent of maternal anemia status. These findings support the independent role of SARS-CoV-2 in causing placental hypoxia in pregnant women.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
George Firth, Eleni Georgiadou, Alexander Griffiths, Maral Amrahli, Jana Kim, Zilin Yu, Ming Hu, Theodora J. Stewart, Isabelle Leclerc, Haruka Okamoto, Daniel Gomez, Philip J. Blower, Guy A. Rutter
Summary: Common variants in the SLC30A8 gene are associated with altered risk of type 2 diabetes, while rare loss-of-function variants in the gene are protective against the disease. This study found that the R138X mutation in the mouse SLC30A8 gene affects zinc and manganese homeostasis, leading to increased levels of these metals in pancreatic beta cells and improved insulin secretion.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Stavroula Bitsi, Liliane El Eid, Yusman Manchanda, Affiong I. Oqua, Nimco Mohamed, Ben Hansen, Kinga Suba, Guy A. Rutter, Victoria Salem, Ben Jones, Alejandra Tomas
Summary: This study reveals the important role of GLP-1R in the treatment of type 2 diabetes, and the rapid desensitization of stimulated GLP-1Rs by beta-arrestins. By studying KO mice, it was found that they had weaker responses to GLP-1R agonists, but showed improvement 6 hours after agonist injection. This study unveils fundamental aspects of GLP-1R response regulation with direct application to the rational design of GLP-1R-targeting therapeutics.
Article
Cell Biology
Lina Sui, Qian Du, Anthony Romer, Qi Su, Pauline L. Chabosseau, Yurong Xin, Jinrang Kim, Sandra Kleiner, Guy A. Rutter, Dieter Egli
Summary: The rare SLC30A8 mutation is associated with a reduced risk for type 2 diabetes. The mutation does not affect the differentiation and function of beta cells, but results in a lack of crystalline zinc-containing insulin granules. The mutation enhances the protective role of zinc and increases resistance to apoptosis. These findings are important for understanding the protective role of zinc in type 2 diabetes.
Article
Engineering, Biomedical
Qiong Huang, Yuqi Yang, Tianjiao Zhao, Qiaohui Chen, Min Liu, Shuting Ji, Yan Zhu, Yunrong Yang, Jinping Zhang, Haixin Zhao, Yayun Nan, Kelong Ai
Summary: Acute kidney injury (AKI) can lead to kidney function loss and increased mortality. This study discovers that ultra-small Tungsten-based nanodots (TWNDs) can be passively targeted for mitochondrial therapy in AKI, showing high effectiveness in reducing mitochondrial ROS and increasing mitophagy.
BIOACTIVE MATERIALS
(2023)
Review
Engineering, Biomedical
Qiaohui Chen, Yayun Nan, Yuqi Yang, Zuoxiu Xiao, Min Liu, Jia Huang, Yuting Xiang, Xingyu Long, Tianjiao Zhao, Xiaoyuan Wang, Qiong Huang, Kelong Ai
Summary: This review article introduces the potential and advantages of nanodrugs in treating acute kidney injury (AKI). Traditional small molecule drugs have limitations in AKI treatment, while nanodrugs with kidney targeting ability can overcome these limitations and achieve significant therapeutic effects.
BIOACTIVE MATERIALS
(2023)
Review
Endocrinology & Metabolism
Peter J. Thompson, Jasmine Pipella, Guy A. Rutter, Herbert Y. Gaisano, Pere Santamaria
Summary: Type 1 diabetes occurs when the body's immune system mistakenly attacks and destroys pancreatic beta cells. This review highlights recent advances in understanding how early life exposures and stress response pathways impact beta cells and contribute to the autoimmune process in type 1 diabetes. Progress in this area holds promise for developing targeted therapies that could be implemented in the early stages of the disease, potentially in combination with immunotherapies.
Article
Medicine, Research & Experimental
Wing Yan So, Yilie Liao, Wai Nam Liu, Guy A. Rutter, Weiping Han
Summary: PAX6 plays a critical role in the survival of pancreatic beta cells and is down-regulated under diabetic conditions. Overexpression of PAX6 promotes beta cell survival and improves glycemic control after islet transplantation.
EMBO MOLECULAR MEDICINE
(2023)