K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

(2020) Anna Ciesielska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

(2020) Shintaro Maeda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion

(2020) Kazuaki Matoba et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice

(2019) Christine Quach et al.   Nature Communications

SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin‐2

(2018) Kristiane Søreng et al.   EMBO REPORTS

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome

(2018) Raffaella De Pace et al.   PLoS Genetics

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

AP-4 mediates export of ATG9A from thetrans-Golgi network to promote autophagosome formation

(2017) Rafael Mattera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation

(2017) Chih-Yuan Lee et al.   Nature Communications

Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila

(2017) Jung-Kun Wen et al.   eLife

Ubiquitin-Specific Protease 14 Negatively Regulates Toll-Like Receptor 4-Mediated Signaling and Autophagy Induction by Inhibiting Ubiquitination of TAK1-Binding Protein 2 and Beclin 1

(2017) Yoon Min et al.   Frontiers in Immunology

Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

(2016) Changqian Zhou et al.   CELL RESEARCH

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

(2016) Daichao Xu et al.   GENES & DEVELOPMENT

The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling

(2016) Fumiaki Ohtake et al.   MOLECULAR CELL

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic

(2015) C. A. Lamb et al.   EMBO JOURNAL

Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology

(2015) Beth Levine et al.   TRENDS IN CELL BIOLOGY

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy

(2014) D. Popovic et al.   EMBO REPORTS

An overview of mechanisms of redox signaling

(2014) Henry Jay Forman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Autophagy supports genomic stability by degrading retrotransposon RNA

(2014) Huishan Guo et al.   Nature Communications

Molecular and Cellular Regulation of Toll-Like Receptor-4 Activity Induced by Lipopolysaccharide Ligands

(2014) Ardiyanto Liaunardy-Jopeace et al.   Frontiers in Immunology

Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes

(2013) Claudia Puri et al.   CELL

Atg9 Interacts with dTRAF2/TRAF6 to Regulate Oxidative Stress-Induced JNK Activation and Autophagy Induction

(2013) Hong-Wen Tang et al.   DEVELOPMENTAL CELL

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells

(2013) Juan F. Linares et al.   MOLECULAR CELL

PtdIns(3)P-bound UVRAG coordinates Golgi–ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex

(2013) Shanshan He et al.   NATURE CELL BIOLOGY

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Beclin1: A role in membrane dynamics and beyond

(2012) Ellen Wirawan et al.   Autophagy

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy

(2012) A. Orsi et al.   MOLECULAR BIOLOGY OF THE CELL

The interplay between autophagy and ROS in tumorigenesis

(2012) Sameera Kongara et al.   Frontiers in Oncology

Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway

(2011) Paul Waltz et al.   Autophagy

Regulation of Toll-like receptor signaling by NDP52-mediated selective autophagy is normally inactivated by A20

(2011) Megumi Inomata et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Ubiquitin: Same Molecule, Different Degradation Pathways

(2010) Michael J. Clague et al.   CELL

Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy

(2010) Hong-Wen Tang et al.   EMBO JOURNAL

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of innate immune responses by autophagy-related proteins

(2010) Tatsuya Saitoh et al.   JOURNAL OF CELL BIOLOGY

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAF6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy

(2010) C. S. Shi et al.   Science Signaling

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL

(2008) Betty Lamothe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY