Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses

Krebs Cycle Reborn in Macrophage Immunometabolism

(2020) Dylan G. Ryan et al.   Annual Review of Immunology

Targeting immunometabolism as an anti-inflammatory strategy

(2020) Eva M. Pålsson-McDermott et al.   CELL RESEARCH

Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking

(2020) Sayaka Ishihara et al.   BMC BIOLOGY

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity

(2020) Elisabeth Salzer et al.   Science Immunology

Lipid Metabolism in Regulation of Macrophage Functions

(2020) Jiawei Yan et al.   TRENDS IN CELL BIOLOGY

Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap

(2019) Jüri Reimand et al.   Nature Protocols

Immune cell metabolism in autoimmunity

(2019) X. Teng et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunometabolism: Insights from the Drosophila model

(2019) Anthony Galenza et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

NF-κB Shapes Metabolic Adaptation by Attenuating Foxo-Mediated Lipolysis in Drosophila

(2019) Maral Molaei et al.   DEVELOPMENTAL CELL

p190RhoGAPs, the ARHGAP35- and ARHGAP5-Encoded Proteins, in Health and Disease

(2019) Héraud et al.   Cells

Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

(2019) Jacqueline M. Cliff et al.   Frontiers in Immunology

RhoA as a Key Regulator of Innate and Adaptive Immunity

(2019) Bros et al.   Cells

Peroxisomes in Immune Response and Inflammation

(2019) Francesca Di Cara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

(2019) Marco Di Gioia et al.   NATURE IMMUNOLOGY

Inflammation-Modulated Metabolic Reprogramming Is Required for DUOX-Dependent Gut Immunity in Drosophila

(2018) Kyung-Ah Lee et al.   Cell Host & Microbe

Macrophages and lipid metabolism

(2018) Anneleen Remmerie et al.   CELLULAR IMMUNOLOGY

Phospholipid subcellular localization and dynamics

(2018) Yanbo Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipid signaling in innate immune cells

(2018) Valerie B. O’Donnell et al.   JOURNAL OF CLINICAL INVESTIGATION

ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease

(2018) Jorge S. Valadas et al.   NEURON

Dietary rescue of lipotoxicity-induced mitochondrial damage in Peroxin19 mutants

(2018) Julia Sellin et al.   PLOS BIOLOGY

Measurement of Mitochondrial Oxygen Consumption in Permeabilized Fibers of Drosophila Using Minimal Amounts of Tissue

(2018) Chloé J Simard et al.   Jove-Journal of Visualized Experiments

Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy

(2018) Francesca Di Cara et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct Roles for Peroxisomal Targeting Signal Receptors Pex5 and Pex7 in Drosophila

(2018) Francesca Di Cara et al.   GENETICS

Peroxisome-Mediated Metabolism Is Required for Immune Response to Microbial Infection

(2017) Francesca Di Cara et al.   IMMUNITY

A New Immunomodulatory Role for Peroxisomes in Macrophages Activated by the TLR4 Ligand Lipopolysaccharide

(2017) Vijith Vijayan et al.   JOURNAL OF IMMUNOLOGY

Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis

(2017) Roni Levin et al.   MOLECULAR BIOLOGY OF THE CELL

Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence

(2017) Jogender Singh et al.   mBio

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

(2017) Claire B. Péan et al.   Nature Communications

Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA

(2017) Ramy Ragheb et al.   Scientific Reports

Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse

(2017) Michael F. Wangler et al.   PLoS Genetics

Quantitative profiling of glycerophospholipids during mouse and human macrophage differentiation using targeted mass spectrometry

(2017) Cuiping Zhang et al.   Scientific Reports

Characterization of the direct targets of FOXO transcription factors throughout evolution

(2016) Ashley E. Webb et al.   AGING CELL

Cellular immune defenses of Drosophila melanogaster

(2016) Brendon Parsons et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Lipidomic analysis of fibroblasts from Zellweger spectrum disorder patients identifies disease-specific phospholipid ratios

(2016) Katharina Herzog et al.   JOURNAL OF LIPID RESEARCH

Role of lipids in the metabolism and activation of immune cells

(2016) Merla J. Hubler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

(2016) Mihaela Pertea et al.   Nature Protocols

Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility inDrosophila

(2016) Barbara Laurinyecz et al.   Open Biology

The Hippo pathway promotes cell survival in response to chemical stress

(2015) F Di Cara et al.   CELL DEATH AND DIFFERENTIATION

JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection

(2015) H. Yang et al.   EMBO REPORTS

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal FoxO signaling is required to survive oral infection in Drosophila

(2015) C Fink et al.   Mucosal Immunology

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

(2015) Jing Geng et al.   NATURE IMMUNOLOGY

Targeting Rho-GTPases in immune cell migration and inflammation

(2014) Maté Biro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

(2014) Irfan J. Lodhi et al.   Cell Metabolism

Cytoskeletal function in the immune system

(2014) Janis K. Burkhardt   IMMUNOLOGICAL REVIEWS

Plasma membrane phosphoinositide balance regulates cell shape duringDrosophilaembryo morphogenesis

(2014) Alessandra Reversi et al.   JOURNAL OF CELL BIOLOGY

FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes

(2014) Yukio Akasaki et al.   Arthritis & Rheumatology

Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking

(2014) Rachael Zoe Murray et al.   Frontiers in Immunology

Lipid antigens in immunity

(2013) C. Marie Dowds et al.   BIOLOGICAL CHEMISTRY

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

TheDrosophilaPlatelet-derived Growth Factor and Vascular Endothelial Growth Factor-Receptor Related (Pvr) Protein Ligands Pvf2 and Pvf3 Control Hemocyte Viability and Invasive Migration

(2013) Brendon Parsons et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages, fat, and the emergence of immunometabolism

(2013) Anthony W. Ferrante   JOURNAL OF CLINICAL INVESTIGATION

FOXO Transcription Factors Regulate Innate Immune Mechanisms in Respiratory Epithelial Cells

(2013) F. Seiler et al.   JOURNAL OF IMMUNOLOGY

Molecular Mechanism of Membrane Binding of the GRP1 PH Domain

(2013) Chun-Liang Lai et al.   JOURNAL OF MOLECULAR BIOLOGY

Peroxisomes take shape

(2013) Jennifer J. Smith et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deficiencies of the Lipid-Signaling Enzymes Phospholipase D1 and D2 Alter Cytoskeletal Organization, Macrophage Phagocytosis, and Cytokine-Stimulated Neutrophil Recruitment

(2013) Wahida H. Ali et al.   PLoS One

Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9

(2013) A. R. Bassett et al.   Biology Open

Intravenous Niacin Acutely Improves the Efficiency of Dietary Fat Storage in Lean and Obese Humans

(2012) R. H. Nelson et al.   DIABETES

Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

(2012) Pavan K. Battiprolu et al.   JOURNAL OF CLINICAL INVESTIGATION

Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

(2012) Federica Facciotti et al.   NATURE IMMUNOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Glycerol Hypersensitivity in a Drosophila Model for Glycerol Kinase Deficiency Is Affected by Mutations in Eye Pigmentation Genes

(2012) Patrick J. Wightman et al.   PLoS One

Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival

(2012) Jatinder K. Juss et al.   PLoS One

An Inventory of Peroxisomal Proteins and Pathways in Drosophila melanogaster

(2012) Joseph E. Faust et al.   TRAFFIC

Thermal sensitivity of mitochondrial functions in permeabilized muscle fibers from two populations of Drosophila simulans with divergent mitotypes

(2011) Nicolas Pichaud et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Cytokine release from innate immune cells: association with diverse membrane trafficking pathways

(2011) P. Lacy et al.   BLOOD

Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis

(2011) Elma Aflaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders

(2011) F. D. Mast et al.   Disease Models & Mechanisms

Rho GTPases and their role in organizing the actin cytoskeleton

(2011) S.-T. Sit et al.   JOURNAL OF CELL SCIENCE

Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation

(2011) Christian D. Sadik et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Macrophage activation differentially modulates particle binding, phagocytosis and downstream antimicrobial mechanisms

(2010) Aja M. Rieger et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Dual Regulation of RA-RhoGAP Activity by Phosphatidic Acid and Rap1 during Neurite Outgrowth

(2010) Takao Kurooka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane

(2010) Amanda L. Neisch et al.   JOURNAL OF CELL BIOLOGY

Metabolic Shifts in Immunity and Inflammation

(2010) D. J. Kominsky et al.   JOURNAL OF IMMUNOLOGY

CDase is a pan-ceramidase in Drosophila

(2010) Changqing Yuan et al.   MOLECULAR BIOLOGY OF THE CELL

FOXO-dependent regulation of innate immune homeostasis

(2010) Thomas Becker et al.   NATURE

WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling

(2010) T. M. Khuong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Vibrio cholerae type VI secretion system displays antimicrobial properties

(2010) D. L. MacIntyre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction

(2009) U. Dasgupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic RNAi screening in Drosophila S2 cells: what have we learned about host–pathogen interactions?

(2008) Sara Cherry   CURRENT OPINION IN MICROBIOLOGY

The role of FoxO in the regulation of metabolism

(2008) D N Gross et al.   ONCOGENE

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE