The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity

T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy

(2020) Amir Sharabi et al.   Nature Reviews Rheumatology

The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation

(2019) Jingwen Li et al.   Frontiers in Immunology

Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells

(2019) Ashwathi S. Mohan et al.   DEVELOPMENTAL CELL

c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells

(2019) Eric A. Shikatani et al.   Cell Reports

‘-Omics’ shed light on B cells in lupus

(2019) Alessandra B. Pernis et al.   NATURE IMMUNOLOGY

Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis

(2019) Nina K. Serwas et al.   Nature Communications

Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

(2019) Madison Bolger-Munro et al.   eLife

The Cytoskeleton as Regulator of Cell Signaling Pathways

(2019) Ossama Moujaber et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects

(2018) Charlotte Schwab et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

American College of Rheumatology Provisional Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus

(2018) Hermine I. Brunner et al.   ARTHRITIS CARE & RESEARCH

Capping protein-controlled actin polymerization shapes lipid membranes

(2018) Katharina Dürre et al.   Nature Communications

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

(2018) Lijian Shao et al.   Nature Communications

The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse

(2018) Raïssa Houmadi et al.   Cell Reports

On the relation between filament density, force generation and protrusion rate in mesenchymal cell motility

(2018) Setareh Dolati et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

(2018) Matthias Schaks et al.   CURRENT BIOLOGY

Primary immunodeficiencies caused by mutations in actin regulatory proteins

(2018) Erin Janssen et al.   IMMUNOLOGICAL REVIEWS

Differential functions of WAVE regulatory complex subunits in the regulation of actin-driven processes

(2017) Christof Litschko et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis

(2017) Ahmet Ozen et al.   NEW ENGLAND JOURNAL OF MEDICINE

VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data

(2017) Heiko Müller et al.   NUCLEIC ACIDS RESEARCH

Single-cell entropy for accurate estimation of differentiation potency from a cell’s transcriptome

(2017) Andrew E. Teschendorff et al.   Nature Communications

FMNL formins boost lamellipodial force generation

(2017) Frieda Kage et al.   Nature Communications

Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease

(2017) Walter H. A. Kahr et al.   Nature Communications

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Familial Mediterranean Fever: Recent Developments in Pathogenesis and New Recommendations for Management

(2017) Seza Özen et al.   Frontiers in Immunology

Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration

(2016) Zhiwen Zhu et al.   DEVELOPMENTAL CELL

Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation

(2016) Anna Julia Squarr et al.   JOURNAL OF CELL BIOLOGY

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton

(2016) Erin Janssen et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes

(2016) Alexander Leithner et al.   NATURE CELL BIOLOGY

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics

(2016) Elisabeth Salzer et al.   NATURE IMMUNOLOGY

The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program

(2015) David Dominguez-Sola et al.   IMMUNITY

Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells

(2015) Selina Jessica Keppler et al.   IMMUNITY

Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome

(2015) Nikita S. Kolhatkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD21−/lowB cells: A Snapshot of a Unique B Cell Subset in Health and Disease

(2015) K. Thorarinsdottir et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

(2014) Baoyu Chen et al.   CELL

Actin cytoskeletal defects in immunodeficiency

(2014) Dale A. Moulding et al.   IMMUNOLOGICAL REVIEWS

Dedicator of cytokinesis 8–deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

(2014) Erin Janssen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Signalling entropy: A novel network-theoretical framework for systems analysis and interpretation of functional omic data

(2014) Andrew E. Teschendorff et al.   METHODS

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

ArrayExpress update—simplifying data submissions

(2014) Nikolay Kolesnikov et al.   NUCLEIC ACIDS RESEARCH

Plug-and-Play Pairing via Defined Divalent Streptavidins

(2013) Michael Fairhead et al.   JOURNAL OF MOLECULAR BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP

(2012) Gaetana Lanzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Paediatric Reference Values for the Peripheral T cell Compartment

(2012) E. J. H. Schatorjé et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity

(2011) Shirly Becker-Herman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B cell subsets in healthy children: Reference values for evaluation of B cell maturation process in peripheral blood

(2010) Barbara Piątosa et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Structure and control of the actin regulatory WAVE complex

(2010) Zhucheng Chen et al.   NATURE

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A point mutation in the murineHem1gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity

(2008) Heon Park et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

(2008) Hart S Dengler et al.   NATURE IMMUNOLOGY