Article
Medicine, General & Internal
Mingqin Ge, Jie Niu, Ping Hu, Aihua Tong, Yan Dai, Fangjiang Xu, Fuyuan Li
Summary: A prognostic ferroptosis-related signature involving eight genes was established for predicting the prognosis of thyroid cancer. Patients in the high-risk group had a significantly poorer prognosis compared to those in the low-risk group. The model showed good predictive performance with AUCs of 0.887, 0.890, and 0.840 for 1-, 2-, and 3-year survival, respectively. The signature, in combination with age, successfully predicted survival probabilities for 1-, 3-, and 5-year time points.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Shilang Xiao, Xiaoming Liu, Lingzhi Yuan, Fen Wang
Summary: This study systematically evaluated the role of ferroptosis-related lncRNAs in GC, and found that risk stratification could reflect the biological characteristics and treatment response of GC patients. The ferroptosis-related lncRNA signature could serve as a reliable biomarker for predicting the prognosis and therapeutic response of GC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Haoran Li, Bing Xu, Jing Du, Yunyi Wu, Fangchun Shao, Yan Gao, Ping Zhang, Junyu Zhou, Xiangmin Tong, Ying Wang, Yanchun Li
Summary: This study found that autophagy exhibited significant heterogeneity in gastric cancer patients. Three autophagy patterns were closely associated with overall survival and the immunophenotype of the tumor microenvironment. Autophagy score could serve as an independent prognostic biomarker and predict the effectiveness of immunotherapy and ferroptosis-based therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Hanwen Su, Youyi Liu, Jingtao Huang
Summary: This study found that ferroptosis, an iron-dependent cell death program, is related to the development of HBV-related hepatocellular carcinoma (HCC). Among the ferroptosis-related genes, SLC1A5 was identified as an independent risk factor for HBV-related HCC and was associated with poor prognosis, advanced progression, and an immunosuppression microenvironment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Yulian Zhang, Chuanpeng Zhang, Yanbo Yang, Guohui Wang, Zai Wang, Jiang Liu, Li Zhang, Yanbing Yu
Summary: In this study, a four-gene PRGs signature was constructed, which can effectively diagnose glioma and predict its prognosis. The signature is associated with the tumor microenvironment and immune cell infiltration in glioma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Congcong Xu, Hao Chen
Summary: The study developed a predictive model containing five ferroptosis-linked genes, with ALOX5 and GCH1 identified as independent predictive factors. Functional assessment revealed enriched immune-related cascades, and immune infiltrating analysis showed distinct immune microenvironments.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Wei Shao, Zongcheng Yang, Yue Fu, Lixin Zheng, Fen Liu, Li Chai, Jihui Jia
Summary: This study classified gastric cancer patients based on pyroptosis-related regulators and developed a prognostic model called PS-score, which can predict patients' prognosis and overall survival time. Patients with a low PS-score have more inflammatory cell infiltration and better response to PD1/PD-L1 blockade immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaohu Ouyang, Rui Zhu, Lan Lin, Xunxun Wang, Qigang Zhuang, Desheng Hu
Summary: This study identified ferroptosis-related genes in lung adenocarcinoma and developed a predictive model for prognosis and treatment outcomes. It also discovered a potential therapeutic approach of using immunotherapy and targeting GAPDH to induce ferroptosis in lung adenocarcinoma.
Article
Biochemistry & Molecular Biology
Jun Yang, Yuening Zhang, Jin Duan, Xiaojie Huang, Haibin Yu, Zhongjie Hu
Summary: The study developed a glycolysis-related gene signature based on gene expression profiles of hepatocellular carcinoma tissues, and found that high-risk patients had significantly worse overall survival. The results showed that the glycolysis-related gene signature had good predictive capability for overall survival, and there were significant differences in immune cell infiltration and PD-L1 protein expression in HCC tissues.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Immunology
Yeqin Sha, Rui Jiang, Yi Miao, Shuchao Qin, Wei Wu, Yi Xia, Li Wang, Lei Fan, Hui Jin, Wei Xu, Jianyong Li, Huayuan Zhu
Summary: This study identified differentially expressed pyroptosis-related genes (PRGs) between CLL and normal B cells, and constructed a risk model with three PRG signatures that showed high efficacy in predicting overall survival and time to first treatment in CLL. Functional and pathway analysis further revealed dysregulated immune and inflammatory responses in the high-risk group, as well as decreased immune cell infiltration and activity of immune-related pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Kai Guo, Jiahui Zhao, Qianxu Jin, Hongshan Yan, Yunpeng Shi, Zongmao Zhao
Summary: The pyroptosis-related gene CASP6 is overexpressed in glioma and is associated with patient prognosis and treatment response. CASP6 may serve as a sensitive prognostic marker for glioma patients and guide immunotherapy and temozolomide therapy strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Jiani Yang, Chao Wang, Shanshan Cheng, Yue Zhang, Yue Jin, Nan Zhang, Yu Wang
Summary: Ovarian cancer is a highly lethal gynecological malignancy with limited treatment options. This study identified 3 prognostic genes related to ferroptosis and constructed a nomogram with promising prognostic value. Gene analysis revealed potential pathways and higher m6A levels in the high-risk group. Distinct tumor immune microenvironments were observed between the high-risk and low-risk groups, with implications for immunotherapy and chemotherapy response.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Yan Zhang, Yiran Liang, Yajie Wang, Fangzhou Ye, Xiaoli Kong, Qifeng Yang
Summary: Breast cancer, the most prevalent cancer among women worldwide, presents a challenge for treatment and prognosis due to its heterogeneous nature. This study identified nine genes associated with prognosis in breast cancer patients and developed a risk score formula. The study also established a nomogram that showed powerful predictive ability. Functional analysis revealed a connection between ferroptosis and breast cancer progression and drug resistance.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Neurosciences
Rong-Jun Wan, Wang Peng, Qin-Xuan Xia, Hong-Hao Zhou, Xiao-Yuan Mao
Summary: A majority of ferroptosis-related genes (FRGs) showed differential expression among GBM, LGG, and NON-TUMOR groups (96.6%). Glioma patients with low-risk score had a more favorable clinical outcome, regardless of their tumor grade. Functional analysis revealed a positive correlation between high-risk score group and immune checkpoint blockade-related positive signatures, highlighting the critical role of glioma immunotherapy based on the risk score.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Oncology
Yiming Zhang, Rong He, Xuan Lei, Lianghao Mao, Zhengyu Yin, Xinyu Zhong, Wenbing Cao, Qiping Zheng, Dapeng Li
Summary: Research on the implications of ferroptosis in tumors has rapidly increased in recent decades. This study found that the FRL model can predict the prognosis and immune characteristics of osteosarcoma patients, and is associated with key indicators in the immune tumor microenvironment. Additionally, knockdown of RPARP-AS1 suppressed the malignant activity of osteosarcoma cells, providing insight into more effective treatment strategies.
FRONTIERS IN ONCOLOGY
(2022)