The Pyroptosis-Related Signature Predicts Prognosis and Indicates Immune Microenvironment Infiltration in Gastric Cancer

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

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Development and validation of a hypoxia-immune-based microenvironment gene signature for risk stratification in gastric cancer

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m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

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Gasdermin E suppresses tumour growth by activating anti-tumour immunity

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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

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An immune-related gene prognostic index for head and neck squamous cell carcinoma

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Gastric cancer

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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

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An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer

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The role of pyroptosis in cancer: pro-cancer or pro-“host”?

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Identification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma

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Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

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Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

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Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

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Maftools: efficient and comprehensive analysis of somatic variants in cancer

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Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Elements of cancer immunity and the cancer–immune set point

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Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

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Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

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Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma

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Pore-forming activity and structural autoinhibition of the gasdermin family

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Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway

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Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

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Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

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Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

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GSVA: gene set variation analysis for microarray and RNA-Seq data

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Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

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Genotyping and Genomic Profiling of Non–Small-Cell Lung Cancer: Implications for Current and Future Therapies

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Inferring tumour purity and stromal and immune cell admixture from expression data

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Association of HER2/ErbB2 Expression and Gene Amplification with Pathologic Features and Prognosis in Esophageal Adenocarcinomas

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Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma

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Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1β secretion

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Gene Expression Signature-Based Prognostic Risk Score in Gastric Cancer

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Prognostic Implications of Altered Human Epidermal Growth Factor Receptors (HERs) in Gastric Carcinomas: HER2 and HER3 Are Predictors of Poor Outcome

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IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

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HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing

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HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target

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