Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

Genetic substructure and complex demographic history of South African Bantu speakers

(2021) Dhriti Sengupta et al.   Nature Communications

Adiposity Phenotypes and Subclinical Atherosclerosis in Adults from Sub–Saharan Africa: An H3Africa AWI–Gen Study

(2021) Engelbert A. Nonterah et al.   Global Heart

GWAS in Africans identifies novel lipids loci and demonstrates heterogenous association within Africa

(2021) Amy R Bentley et al.   HUMAN MOLECULAR GENETICS

The power of genetic diversity in genome-wide association studies of lipids

(2021) Sarah E. Graham et al.   NATURE

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

(2020) Fiona A. Hagenbeek et al.   Nature Communications

Evaluating the promise of inclusion of African ancestry populations in genomics

(2020) Amy R. Bentley et al.   npj Genomic Medicine

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

(2020) Tom G. Richardson et al.   PLOS MEDICINE

Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations

(2020) Alicia R. Martin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

(2019) Anne E. Justice et al.   NATURE GENETICS

Genome-wide association study of blood lipids in Indians confirms universality of established variants

(2019) Khushdeep Bandesh et al.   JOURNAL OF HUMAN GENETICS

The Missing Diversity in Human Genetic Studies

(2019) Giorgio Sirugo et al.   CELL

PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations

(2019) Mihir A Kamat et al.   BIOINFORMATICS

Genetic analyses of diverse populations improves discovery for complex traits

(2019) Genevieve L. Wojcik et al.   NATURE

Analysis of polygenic risk score usage and performance in diverse human populations

(2019) L. Duncan et al.   Nature Communications

PRSice-2: Polygenic Risk Score software for biobank-scale data

(2019) Shing Wan Choi et al.   GigaScience

Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa

(2019) Deepti Gurdasani et al.   CELL

The transferability of lipid loci across African, Asian and European cohorts

(2019) Karoline Kuchenbaecker et al.   Nature Communications

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

(2018) Cassandra N Spracklen et al.   HUMAN MOLECULAR GENETICS

A large electronic-health-record-based genome-wide study of serum lipids

(2018) Thomas J. Hoffmann et al.   NATURE GENETICS

Gene-based association study for lipid traits in diverse cohorts implicates BACE1 and SIDT2 regulation in triglyceride levels

(2018) Angela Andaleon et al.   PeerJ

Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study

(2018) Stuart A. Ali et al.   Global Health Action

Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics

(2018) Shakuntala Baichoo et al.   BMC BIOINFORMATICS

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

(2018) Derek Klarin et al.   NATURE GENETICS

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

The burden of dyslipidaemia and factors associated with lipid levels among adults in rural northern Ghana: An AWI-Gen sub-study

(2018) Godfred Agongo et al.   PLoS One

The genomic landscape of African populations in health and disease

(2017) Charles N. Rotimi et al.   HUMAN MOLECULAR GENETICS

Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos

(2017) Mariaelisa Graff et al.   Lipids in Health and Disease

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium

(2017) Maggie C. Y. Ng et al.   PLoS Genetics

Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations

(2017) Bram P. Prins et al.   Scientific Reports

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

FINEMAP: efficient variable selection using summary data from genome-wide association studies

(2016) Christian Benner et al.   BIOINFORMATICS

Analysis with the exome array identifies multiple new independent variants in lipid loci

(2016) Stavroula Kanoni et al.   HUMAN MOLECULAR GENETICS

Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci

(2016) Niha Zubair et al.   HUMAN MOLECULAR GENETICS

Genomics is failing on diversity

(2016) Alice B. Popejoy et al.   NATURE

Fine Mapping Causal Variants with an Approximate Bayesian Method Using Marginal Test Statistics

(2015) Wenan Chen et al.   GENETICS

Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome

(2015) Fasil Tekola-Ayele et al.   MOLECULAR GENETICS AND METABOLISM

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Fine Mapping Causal Variants with an Approximate Bayesian Method Using Marginal Test Statistics

(2015) Wenan Chen et al.   GENETICS

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks

(2014) Gina M. Peloso et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimating Genome-Wide Significance for Whole-Genome Sequencing Studies

(2014) ChangJiang Xu et al.   GENETIC EPIDEMIOLOGY

Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies

(2014) Gleb Kichaev et al.   PLoS Genetics

Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations

(2013) Marc A. Coram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

(2013) Ying Wu et al.   PLoS Genetics

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies

(2011) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS