Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis

Transitional B cell cytokines predict renal allograft outcomes

(2021) Aravind Cherukuri et al.   Science Translational Medicine

Implication of TIGIT+ human memory B cells in immune regulation

(2021) Md Mahmudul Hasan et al.   Nature Communications

CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells

(2020) Rebeca Arroyo Hornero et al.   Communications Biology

STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs

(2020) Favour O. Oladipupo et al.   Scientific Reports

CD24hiCD38hi and CD24hiCD27+ Human Regulatory B Cells Display Common and Distinct Functional Characteristics

(2019) Md Mahmudul Hasan et al.   JOURNAL OF IMMUNOLOGY

Engineering of Primary Human B cells with CRISPR/Cas9 Targeted Nuclease

(2018) Matthew J. Johnson et al.   Scientific Reports

Induction and Differentiation of IL-10–Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients

(2017) Zsuzsanna Bankó et al.   JOURNAL OF IMMUNOLOGY

Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?

(2016) I. Rebollo-Mesa et al.   AMERICAN JOURNAL OF TRANSPLANTATION

B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer

(2016) Alexandre Tang et al.   INTERNATIONAL JOURNAL OF CANCER

B Cell Responses Associated with Vaccine-Induced Delayed SIVmac251Acquisition in Female Rhesus Macaques

(2016) Venkatramanan Mohanram et al.   JOURNAL OF IMMUNOLOGY

TIM-1 Signaling Is Required for Maintenance and Induction of Regulatory B Cells

(2015) M. Y. Yeung et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CD24hiCD27+ and plasmablast-like regulatory B cells in human chronic graft-versus-host disease

(2015) A. de Masson et al.   BLOOD

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

Tim-1 Is Essential for Induction and Maintenance of IL-10 in Regulatory B Cells and Their Regulation of Tissue Inflammation

(2015) Sheng Xiao et al.   JOURNAL OF IMMUNOLOGY

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

(2015) Shabnam Shalapour et al.   NATURE

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

(2014) Nesrine I. Affara et al.   CANCER CELL

TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance

(2014) Kang Mi Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Regulatory B cells are induced by gut microbiota–driven interleukin-1β and interleukin-6 production

(2014) Elizabeth C Rosser et al.   NATURE MEDICINE

Interleukin-35 induces regulatory B cells that suppress autoimmune disease

(2014) Ren-Xi Wang et al.   NATURE MEDICINE

IL-10-Producing B Cells Are Induced Early in HIV-1 Infection and Suppress HIV-1-Specific T Cell Responses

(2014) Jun Liu et al.   PLoS One

The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges

(2013) A. P. Hutchins et al.   Briefings in Functional Genomics

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses

(2013) Willem van de Veen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Bioinformatics Approach Identifies Signal Transducer and Activator of Transcription-3 and Checkpoint Kinase 1 as Upstream Regulators of Kidney Injury Molecule-1 after Kidney Injury

(2013) A. K. Ajay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Homing of Regulatory T Cells to Human Skin Is Important for the Prevention of Alloimmune-Mediated Pathology in an In Vivo Cellular Therapy Model

(2013) Fadi Issa et al.   PLoS One

B Cells Promote Tumor Progression via STAT3 Regulated-Angiogenesis

(2013) Chunmei Yang et al.   PLoS One

CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation

(2013) F. Flores-Borja et al.   Science Translational Medicine

Unknown

(2012) Hernandez Silva et al.   MOLECULAR MEDICINE

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice

(2012) Sheng Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis

(2012) Natalie A Carter et al.   ARTHRITIS RESEARCH & THERAPY

Tuning of CD40–CD154 Interactions in Human B-Lymphocyte Activation: A Broad Array of In Vitro Models for a Complex In Vivo Situation

(2011) Sonia Néron et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The absence of B lymphocytes reduces the number and function of T-regulatory cells and enhances the anti-tumor response in a murine tumor model

(2011) Tamar Tadmor et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Human T cells induce their own regulation through activation of B cells

(2011) Sébastien Lemoine et al.   JOURNAL OF AUTOIMMUNITY

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice

(2011) Qing Ding et al.   JOURNAL OF CLINICAL INVESTIGATION

B Lymphocytes Differentially Influence Acute and Chronic Allograft Rejection in Mice

(2011) D. J. DiLillo et al.   JOURNAL OF IMMUNOLOGY

Mice Lacking Endogenous IL-10-Producing Regulatory B Cells Develop Exacerbated Disease and Present with an Increased Frequency of Th1/Th17 but a Decrease in Regulatory T Cells

(2011) N. A. Carter et al.   JOURNAL OF IMMUNOLOGY

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

(2010) Pauline Andreu et al.   CANCER CELL

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

(2010) Pervinder Sagoo et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a B cell signature associated with renal transplant tolerance in humans

(2010) Kenneth A. Newell et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory B Cells (B10 Cells) Have a Suppressive Role in Murine Lupus: CD19 and B10 Cell Deficiency Exacerbates Systemic Autoimmunity

(2010) R. Watanabe et al.   JOURNAL OF IMMUNOLOGY

In vivo prevention of transplant arteriosclerosis by ex vivo–expanded human regulatory T cells

(2010) Satish N Nadig et al.   NATURE MEDICINE

Ex Vivo–Expanded Human Regulatory T Cells Prevent the Rejection of Skin Allografts in a Humanized Mouse Model

(2010) Fadi Issa et al.   TRANSPLANTATION

Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/lpr Mice

(2009) P. A. Blair et al.   JOURNAL OF IMMUNOLOGY

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY