Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

Relapse fated latent diagnosis subclones in acute B lineage leukaemia are drug tolerant and possess distinct metabolic programs

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The pseudo-caspase FLIP(L) regulates cell fate following p53 activation

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Targeting Cancer Cell Dormancy

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Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways

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Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors

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Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

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Cellular interactions constrain tumor growth

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Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state

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The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes

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Blastocyst activation engenders transcriptome reprogram affecting X-chromosome reactivation and inflammatory trigger of implantation

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Slow growth causes bacterial persistence

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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

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The role of the refractory period in diapause length determination in a freshwater crustacean

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Neoadjuvant-intensive androgen deprivation therapy selects for prostate tumor foci with diverse subclonal oncogenic alterations

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Toward Minimal Residual Disease-Directed Therapy in Melanoma

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Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

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Research advances on embryonic diapause in mammals

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Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

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XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data

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Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention

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Maftools: efficient and comprehensive analysis of somatic variants in cancer

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Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

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Oncogenic KRAS-associated gene signature defines co-targeting of CDK4/6 and MEK as a viable therapeutic strategy in colorectal cancer

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The mTOR inhibition in concurrence with ERK1/2 activation is involved in excessive autophagy induced by glycyrrhizin in hepatocellular carcinoma

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Mechanisms of animal diapause: recent developments from nematodes, crustaceans, insects, and fish

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MultiQC: summarize analysis results for multiple tools and samples in a single report

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Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

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Inhibition of mTOR induces a paused pluripotent state

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Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

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Distinguishing between resistance, tolerance and persistence to antibiotic treatment

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Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

(2016) Michael Ramirez et al.   Nature Communications

Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaques

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DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

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A Review of the Evolution of Systemic Chemotherapy in the Management of Colorectal Cancer

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Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis

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Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

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Irinotecan Induces Cell Cycle Arrest, but Not Apoptosis or Necrosis, in Caco-2 and CW2 Colorectal Cancer Cell Lines

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Sequenza: allele-specific copy number and mutation profiles from tumor sequencing data

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Embryonic diapause: development on hold

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Self-renewal as a therapeutic target in human colorectal cancer

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A problem of persistence: still more questions than answers?

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ID1 and ID3 Regulate the Self-Renewal Capacity of Human Colon Cancer-Initiating Cells through p21

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VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

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Comprehensive molecular characterization of human colon and rectal cancer

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

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Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

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New-found fundamentals of bacterial persistence

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The RB family is required for the self-renewal and survival of human embryonic stem cells

(2012) Jamie F. Conklin et al.   Nature Communications

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

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Autophagy Regulates Embryonic Survival During Delayed Implantation

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A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

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A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

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edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

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Cell cycle arrest as a hallmark of insect diapause: Changes in gene transcription during diapause induction in the drosophilid fly, Chymomyza costata

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification

(2009) Athanasia Spandidos et al.   NUCLEIC ACIDS RESEARCH

mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex

(2009) E. Y. Chan   Science Signaling

Power-Law Distributions in Empirical Data

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Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

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