Article
Biochemical Research Methods
Maxwell Neal, Deepan Thiruppathy, Karsten Zengler
Summary: This study developed a genome-scale metabolic model of B. fragilis strain 638R, providing a basis for understanding its relationship with human diet and metabolic products.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Christopher J. Anderson, Christopher B. Medina, Brady J. Barron, Laura Karvelyte, Tania Love Aaes, Irina Lambertz, Justin S. A. Perry, Parul Mehrotra, Amanda Goncalves, Kelly Lemeire, Gillian Blancke, Vanessa Andries, Farzaneh Ghazavi, Arne Martens, Geert van Loo, Lars Vereecke, Peter Vandenabeele, Kodi S. Ravichandran
Summary: The study demonstrates how nutrients released from apoptotic cells can promote the growth of Enterobacteriaceae and highlights the role of pyruvate formate-lyase-encoding pflB gene in bacterial colonization in various contexts. These findings provide new insights into host-pathogen interactions and have implications for gut inflammation and chemotherapy treatment.
Review
Multidisciplinary Sciences
Jee-Yon Lee, Renee M. Tsolis, Andreas J. Baumler
Summary: Changes in gut microbiota composition are linked to various human diseases. However, defining homeostasis or dysbiosis based on the presence or absence of specific microbial species has been unsuccessful. The adult gut microbiota is regulated by diet and host factors, with oxygen and nitrate availability shaping the bacterial community in different parts of the gut. Poor diet weakens host control mechanisms, potentially leading to dysbiosis. Therefore, quantifying host parameters that control microbial growth could offer alternative approaches to define and remediate dysbiosis.
Article
Cell Biology
Meihui Cui, Tao Sun, Shubin Li, Huizhuo Pan, Jing Liu, Xinyu Zhang, Lianyue Li, Shanshan Li, Chunyang Wei, Chengzhuang Yu, Chun Yang, Ning Ma, Binglin Ma, Shenjunjie Lu, Jin Chang, Weiwen Zhang, Hanjie Wang
Summary: Recombinant bacterial colonization is essential in disease prevention, alleviation, and treatment, with the success of application hinges on efficient spatiotemporal colonization of host gut. The use of engineered upconversion microgels and light-responsive bacteria in this study demonstrated controlled and effective colonization of EcN, which successfully alleviated DSS-induced colitis in mice, potentially advancing the clinical application of engineered microbial therapeutics.
Article
Biochemistry & Molecular Biology
Changlu Qi, Yiting Cai, Kai Qian, Xuefeng Li, Jialiang Ren, Ping Wang, Tongze Fu, Tianyi Zhao, Liang Cheng, Lei Shi, Xue Zhang
Summary: The gut microbiota plays a crucial role in maintaining health, and disruptions can lead to disorders. The gutMDisorder database provides a valuable resource for studying dysbiosis, and the latest version offers expanded data and improved features.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yi Yang, Mytien Nguyen, Varnica Khetrapal, Nicole D. Sonnert, Anjelica L. Martin, Haiwei Chen, Martin A. Kriegel, Noah W. Palm
Summary: This study reveals that within-host evolution of gut commensal bacteria plays a critical role in bacterial translocation and initiation of inflammation. Gut microbiota strains can adapt and evolve, affecting their propensity to elicit inflammatory diseases. The changes in bacterial behavior are associated with genetic mutations, altered microbial gene expression programs, and remodelled cell wall structures.
Review
Gastroenterology & Hepatology
Liang Chi, Pengcheng Tu, Hongyu Ru, Kun Lu
Summary: The dysbiosis of gut microbiota induced by xenobiotic exposure is a key factor in affecting host health, yet the specific health effects are still unclear. Future studies need to combine technologies to accurately assess this dysbiosis and its impact on host health.
Review
Pharmacology & Pharmacy
Miguel Silva, Valentina Brunner, Markus Tschurtschenthaler
Summary: Colorectal cancer is a complex condition caused by a combination of environmental, genetic, and epigenetic factors, with disruptions in gut microbiota structure associated with various intestinal diseases, including cancer. Bacteria can induce cellular transformation and promote tumor progression through mechanisms such as biofilm formation and genotoxin secretion. The gut microbiota is also involved in drug metabolism, radiotherapy responses, and targeted immunotherapy, with therapy efficacy varying based on the composition of the host's gut microbiota.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Matthew R. Volpe, Jose A. Velilla, Martin Daniel-Ivad, Jenny J. Yao, Alessia Stornetta, Peter W. Villalta, Hsin-Che Huang, Daniel A. Bachovchin, Silvia Balbo, Rachelle Gaudet, Emily P. Balskus
Summary: In this study, small molecule boronic acid inhibitors were developed to inhibit the biosynthesis of the human gut bacterial genotoxin colibactin. These inhibitors effectively block the genotoxic effects of colibactin on eukaryotic cells by engaging with the peptidase ClbP. The availability of these inhibitors allows for precise control over colibactin production, enabling further study of its contributions to colorectal cancer.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Wei Li, Xin Yi, Baoyun Wu, Xiang Li, Boping Ye, Ziqi Deng, A. Runa, Sanlong Hu, Dongdong Li, Hao Wu, Zhenming Zhou
Summary: Neonatal calf diarrhea is associated with a decrease in gut microbiota diversity and an increase in Proteobacteria and Actinobacteriota. Dysbiosis of the fecal microbiome is identified as a significant characteristic of NCD, with an increased abundance of Lactobacillus during recovery.
FERMENTATION-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Anatoly V. Skalny, Michael Aschner, Xin Gen Lei, Viktor A. Gritsenko, Abel Santamaria, Svetlana I. Alekseenko, Nagaraja Tejo Prakash, Jung-Su Chang, Elena A. Sizova, Jane C. J. Chao, Jan Aaseth, Alexey A. Tinkov
Summary: The present study reviewed the association between Zn status and gut microbiota characteristics, as well as the potential role of Zn-induced microbiota in modulating systemic effects. The data showed a close relationship between Zn metabolism and gut microbiota, with Zn being a significant factor for gut bacteria biodiversity. Physiological and nutritional Zn doses improved gut wall integrity, while Zn overexposure induced substantial alterations in gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Jorge Armando Jimenez-Avalos, Gerardo Arrevillaga-Boni, Lorena Gonzalez-Lopez, Zaira Yunuen Garcia-Carvajal, Marisela Gonzalez-Avila
Summary: A healthy Human Gut Microbial Ecosystem (HGME) is essential for the proper functioning of the body, with dysbiosis potentially leading to various disorders. Different methods such as diet, probiotics, antibiotics, and Fecal Microbiota Transplantation (FMT) can help restore or maintain the balance of Gut Microbiota (GM) populations. New approaches such as engineered nanomaterials, phagotherapy, antimicrobial peptides, non-antibiotic drugs, vaccines, and immunoglobulins are promising strategies for modulating HGME.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Immunology
Mariana Izquierdo, Joaquin Lopez, Pablo Gallardo, Roberto M. Vidal, Juan C. Ossa, Mauricio J. Farfan
Summary: This study evaluated the role of Citrobacter werkmanii and Escherichia albertii in the virulence of Shiga toxin-producing and enteroaggregative Escherichia coli pathotypes, revealing their effects on gene expression and toxin secretion.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yucheng Zhang, Peng Tan, Ying Zhao, Xi Ma
Summary: This review focuses on recent discoveries about the etiology, pathogenesis, and clinical manifestation of enterotoxigenic Escherichia coli (ETEC), as well as the colonization resistances mediated by gut microbiota and preventative strategies against ETEC.
Article
Biochemistry & Molecular Biology
Weike Qian, Mingyang Li, Leilei Yu, Fengwei Tian, Jianxin Zhao, Qixiao Zhai
Summary: This study examined the effects of taurine on the intestinal flora and homeostasis of mice. The results showed that taurine supplementation could regulate the intestinal microflora, alter fecal bile acid composition, boost intestinal immunity, resist pathogenic bacterial infections, and enhance flora diversity. Taurine has the potential to shape the gut microbiota of mice and positively affect the restoration of intestinal homeostasis.