Article
Nanoscience & Nanotechnology
Changsong Wu, Meihui Cui, Li Cai, Chen Chen, Xiaohui Zhu, Yihan Wu, Jinliang Liu, Hanjie Wang, Yong Zhang
Summary: This study constructs a two-step synergistic therapy platform for tumor treatment using upconversion nanoparticles and engineered bacteria. The first step involves the activation of a photosensitizer to treat primary tumors, while the second step activates engineered bacteria to produce interferon and regulate immune pathways for joint immunotherapy to inhibit the growth of distant tumors.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Editorial Material
Microbiology
Jitender Yadav, Nayanan Nathan, Dana J. Philpott
Summary: This study demonstrates that retinoic acid produced by symbiotic segmented filamentous bacteria in the intestine can enhance host intestinal epithelial defense and mediate early innate immune protection against Citrobacter rodentium infection.
CELL HOST & MICROBE
(2021)
Article
Engineering, Biomedical
Yanbin Zhao, Peng He, Junyan Yao, Mei Li, Bin Wang, Linyuan Han, Zhihai Huang, Chao Guo, Jing Bai, Feng Xue, Yu Cong, Weihua Cai, Paul K. Chu, Chenglin Chu
Summary: In this study, a self-healing polymeric coating was constructed on a magnesium alloy for orthopedic implants. The coating incorporated a stimuli-responsive drug delivery nanoparticle platform and showed fast and stable water-enabled self-healing capacity. It also exhibited good antibacterial properties and promoted cell compatibility, osteogenesis, and angiogenesis.
Article
Chemistry, Multidisciplinary
Kaili Yang, Weijun Xiu, Yuqing Li, Dou Wang, Qirui Wen, Lihui Yuwen, Xiao Li, Zhaowei Yin, Bin Liang, Lianhui Wang
Summary: In this study, a near-infrared responsive 2D nanozyme was developed for efficient treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The nanozyme exhibited effective antibacterial properties against MRSA through catalytic and photothermal effects. The results showed that the nanozyme had high bactericidal activity against MRSA under near-infrared light irradiation and promoted wound healing.
Article
Chemistry, Applied
Buket Alkan-Tas, Ekin Berksun, Cuneyt Erdinc Tas, Serkan Unal, Hayriye Unal
Summary: This study presents a new approach to disinfection using hybrid coatings that can physically destroy bacteria through photothermal therapy. The coatings demonstrate a high temperature stability and antibiofilm properties, showing great potential for surface disinfection activated by near-infrared light.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Engineering, Environmental
Huizhuo Pan, Lianyue Li, Gaoju Pang, Chunli Han, Baona Liu, Yingying Zhang, Yue Shen, Tao Sun, Jing Liu, Jin Chang, Hanjie Wang
Summary: Using near-infrared light-responsive bacteria as antitumor agents can efficiently inhibit tumor growth and achieve precise tumor ablation, thus improving the controllability of treatment.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Multidisciplinary
Shaoqi Qu, Xiaoyong Huang, Xiangbin Song, Yifan Wu, Xiaowei Ma, Jianzhong Shen, Kui Zhu
Summary: This study developed functional nanoparticles that enhance the accumulation of intracellular antibiotics through increased endocytosis, resulting in high efficacy against multidrug-resistant bacteria and pathogenic bacteria. The subcellular behavior of the nanoparticles was modulated to accurately target specific locations within the cells.
Review
Polymer Science
Yunlong Yu, Maria Brio Perez, Cong Cao, Sissi de Beer
Summary: Control of adhesion and friction in liquid environments using surface-bound stimulus responsive polymers is crucial in biomedical and industrial applications. Polymer brushes play a key role in the specific interactions between surfaces, affecting the swelling and tribomechanical properties of the polymer film. Understanding these interactions and their changes in varying environments is essential for designing effective smart coatings. The potential impact of polymer-based smart adhesives and lubricants on industry and society is also discussed in this review.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jun Bao, Lili Li, Yangheng Zhang, Min Wang, Faming Chen, Shaohua Ge, Bin Chen, Fuhua Yan
Summary: This study aimed to investigate whether periodontitis induces dysbiosis of gut microbiota through invasion by salivary microbes. The results showed significant differences in both the faecal and salivary microbiota between periodontally healthy participants and patients with severe periodontitis. Furthermore, transplantation of salivary microbes into mice revealed significant differences in the composition of the gut microbiota and alterations in intestinal health-related markers. In addition, salivary microbes were found to persist in the gut for at least 24 hours.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Green & Sustainable Science & Technology
Haijun Wang, Qian Zhang, Xinyu Zhang, Kexin Zhang, Xichen Zhao, Ruiling Zhang, Zhong Zhang
Summary: A NIR laser-activated pesticide-free nanoplatform was developed for precise photothermal killing of housefly larvae, demonstrating excellent biocompatibility and environmental friendliness.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2022)
Article
Allergy
Tom Marrs, Jay-Hyun Jo, Michael R. Perkin, Damian W. Rivett, Adam A. Witney, Kenneth D. Bruce, Kirsty Logan, Joanna Craven, Suzana Radulovic, Serge A. Versteeg, Ronald van Ree, W. H. Irwin McLean, David P. Strachan, Gideon Lack, Heidi H. Kong, Carsten Flohr
Summary: The study found that characteristics of the infant gut microbiota at 3 months were related to cesarean birth, with a higher abundance of Clostridium sensu stricto at 3 months being positively correlated with atopic dermatitis. Transition to Bacteroides-rich communities and influx of adult-specific microbes were observed during the first year of life in selected cases and controls with longitudinal samples. The introduction of allergenic solids from 3 months alongside breast-feeding led to a significant increase in Shannon diversity and specific microbial representation, such as genera belonging to Prevotellaceae and Proteobacteria (e.g. Escherichia/Shigella).
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Maria Esteban-Torres, Lorena Ruiz, Valerio Rossini, Ken Nally, Douwe van Sinderen
Summary: The human gut microbiota plays a crucial role in host metabolism and physiology, impacting host health in various ways. This complex microbial community has developed metabolic strategies to survive and thrive in the gut environment. Glycogen accumulation, specifically in gut commensals, has been associated with important physiological functions, and understanding its role can provide insights into the composition and functionality of the gut microbiota.
Article
Biology
Ozioma S. S. Chioma, Elizabeth K. K. Mallott, Austin Chapman, Joseph C. C. Van Amburg, Hongmei Wu, Binal Shah-Gandhi, Nandita Dey, Marina E. E. Kirkland, M. Blanca Piazuelo, Joyce Johnson, Gordon R. R. Bernard, Sobha R. R. Bodduluri, Steven Davison, Bodduluri Haribabu, Seth R. R. Bordenstein, Wonder P. P. Drake
Summary: The gut microbiota plays a significant role in the progression of lung fibrosis. Germ-free mice are protected from lung fibrosis, while mice in ABSL-1 and ABSL-2 environments develop different degrees of lung fibrosis. The diversity of gut microbiota and the IL-6/STAT3/IL-17A signaling in pulmonary CD4+ T cells are associated with the severity of lung fibrosis.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lei Feng, Zhenhao Tian, Ming Zhang, Xin He, Xiangge Tian, Zhenlong Yu, Xiaochi Ma, Chao Wang
Summary: A NIR fluorescent probe, DDAA, derived from fluorophore DDAO with alanine as the recognition group, was developed for sensing aminopeptidase N (APN) in gut microbiota. The probe successfully identified target bacteria and saccharomycete possessing active APN from human feces using real-time fluorescence imaging.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Bang An, Mingcong Xu, Jiaming Sun, Wenye Sun, Yuanyuan Miao, Chunhui Ma, Sha Luo, Jian Li, Wei Li, Shouxin Liu
Summary: We prepared photonic composites with a tunable chiral nematic structure by self-assembly of cellulose nanocrystals and waterborne polyurethane. The reflected wavelength increased with increasing WPU content due to the increase of the chiral nematic pitch. Higher WPU content also led to better mechanical properties. The composites formed strong adhesion forces with wood substrates and invisible patterns could be written and revealed temporarily using MgCl2 solution as an ink.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Lianyue Li, Chun Yang, Binglin Ma, Shenjunjie Lu, Jing Liu, Yiyang Pan, Xuyan Wang, Yiliang Zhang, Hanjie Wang, Tao Sun, Duo Liu
Summary: Genetically modified engineered microorganisms have been encapsulated in hydrogels to treat skin diseases. A photoautotrophic living material containing an engineered microbial consortium has been designed and fabricated, which can function stably for a longer period of time. The living material has been tested in a rat-skin defect model and shown to promote wound healing more effectively compared to control groups.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Meihui Cui, Wei Ling, Lili Zhang, Yayang Li, Jing Liu, Tao Sun, Binglin Ma, Shenjunjie Lu, Huizhuo Pan, Gaoju Pang, Yingying Zhang, Shufang Zhang, Xian Huang, Peiqi Zhao, Duo Liu, Hanjie Wang
Summary: This article presents a smartphone-controlled bioelectronic drug system for chronic kidney disease monitoring, which allows real-time diagnosis and treatment. The system utilizes a urine-based colorimetric sensor and engineered bacteria to quantify pathology and modulate diseases, with the help of smartphone applications for image capture and wireless transmission.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Tao Sun, Zhixiang Li, Shubin Li, Lei Chen, Weiwen Zhang
Summary: In this study, a fast-growing cyanobacterium was utilized to address inherent issues associated with cyanobacterial strains and achieve CO2-based myo-inositol biosynthesis. Through various strategies, the researchers successfully improved cell growth and achieved the highest production of myo-inositol from CO2 in cyanobacteria. Metabolomic analysis was also applied to further optimize the process.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Environmental Sciences
Xiaofei Zhu, Zipeng Li, Yindong Tong, Lei Chen, Tao Sun, Weiwen Zhang
Summary: The over proliferation of harmful cyanobacteria and their cyanotoxins resulted in damaged aquatic ecosystem, polluted drinking water and threatened human health. Cyanophages, as a potential strategy to deal with cyanobacterial blooms, have limited host range and/or lysis efficiency, necessitating the construction of non-natural cyanophages via artificial modification, design and synthesis. This review summarizes the representative cyanophages, explores in-silico design principles, and discusses the progress and challenges of synthesizing artificial cyanophages.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Physical
Xinyu Zhang, Ning Ma, Wei Ling, Gaoju Pang, Tao Sun, Jing Liu, Huizhuo Pan, Meihui Cui, Chunli Han, Chun Yang, Jin Chang, Xian Huang, Hanjie Wang
Summary: This study developed a micro-nano optogenetic system based on probiotics for in situ controllable drug delivery in the intestinal tract. Optogenetic engineered Lactococcus lactis was orally administrated and optical signals were remotely controlled using a wearable optical device. The L. lactis could be customized to secrete peptides according to the optical signals. Upconversion microcapsules were introduced to improve the excitation wavelength of the optogenetic system. This strategy has promising biomedical potential for expanding the toolbox for intestinal engineered bacteria.
Article
Engineering, Biomedical
Xinyu Zhang, Gaoju Pang, Tao Sun, Xinyu Liu, Huizhuo Pan, Yingying Zhang, Jing Liu, Jin Chang, Hanjie Wang, Duo Liu
Summary: Microbes are able to regulate brain function through the gut-brain axis. Engineered probiotics and optogenetics provide a promising approach to modulate the gut-brain axis in situ. In this study, a red-light optogenetic gut probiotic was developed for drug delivery and regulation of host behaviors.
Article
Biochemical Research Methods
Chengzhuang Yu, Shijie Dai, Ziqi Zhang, Shanshan Li, Jingmeng Cheng, Hezhi Hu, Jayne Wu, Junwei Li
Summary: Meat adulteration detection is achieved using a multiplex digital polymerase chain reaction method and a low-cost device. A polydimethylsiloxane microfluidic device is used to automatically load polymerase chain reaction reagents into microchambers. The method can distinguish DNA templates from different animal species and has a limit of detection of 3 copies/μL. The method has potential for point-of-care testing with portable microscopy equipment.
Article
Chemistry, Analytical
Bowen Yang, Chao Wang, Xinyi Liang, Jinchao Li, Shanshan Li, Jie Jayne Wu, Tanbin Su, Junwei Li
Summary: Cell viability is essential for drug screening. This study proposed a low-cost microfluidic impedance cytometry device with 100-micron wide indium tin oxide (ITO) electrodes to assess cell viability without the cytotoxicity of dye staining.
Article
Microbiology
Yu Chen, Pingbo Ge, Tao Sun, Jia Feng, Guorui Li, Jiabao Zhang, Jianting Zhou, Jianlan Jiang
Summary: We synthesized and assembled a truncated cyanophage genome called Syn-P4-8 and transferred it into a nonhost strain to investigate interactions between the virus and the host. Coexpression of certain genes enhanced the salt tolerance of the host strain.
MICROBIOLOGY SPECTRUM
(2023)
Article
Engineering, Electrical & Electronic
Shanshan Li, Chao Wang, Bowen Yang, Xinyi Liang, Junwei Li
Summary: Impedance flow cytometry, as a label-free single cell analysis approach, provides valuable differential signals. However, particle coincidence is inevitable for high throughput detection, especially with high cell concentration or pumping rate. In this study, a numerical model and a novel method for particle coincidence were proposed to investigate multiparticle events. By statistically analyzing signal peaks, the threshold for particle events and the particle numbers were determined. Compared to customized thresholds, a data-driven cutoff line fundamentally improves the accuracy of particle recognition. Moreover, the key operational parameters and the best practices to avoid multiparticle coincidence events in real applications are elucidated.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Jinchao Li, Jingmeng Cheng, Shanshan Li, Jie Jayne Wu, Junwei Li
Summary: In this research, we developed a chamber-based digital PCR (cdPCR) microfluidic device compatible with fluorescence imaging systems for detecting milk adulteration. The device enables digitalization of PCR reagents in microchambers, followed by DNA amplification through thermocycling. Fluorescence images of the microchambers are then analyzed to accurately quantify the target DNA and differentiate intentional adulteration from accidental contamination. The device was validated by authenticating camel milk samples, demonstrating its effectiveness in real biotechnical applications.
Review
Microbiology
Zipeng Li, Xiaofei Zhu, Zhengyu Wu, Tao Sun, Yindong Tong
Summary: This review discusses the classification, biosynthetic pathways, and potential applications of cyanotoxins. By examining representative cyanotoxins and their biosynthetic pathways, the review summarizes and compares recent advances in the heterologous biosynthesis of cyanotoxins in vitro and in vivo, and identifies potential applications and solutions to bottlenecks.
Article
Chemistry, Physical
Xinyu Zhang, Ning Ma, Wei Ling, Gaoju Pang, Tao Sun, Jing Liu, Huizhuo Pan, Meihui Cui, Chunli Han, Chun Yang, Jin Chang, Xian Huang, Hanjie Wang
Summary: A micro-nano optogenetic system based on probiotic was developed to achieve in situ controllable drug delivery in the intestinal tract. The system used a wearable optical device to remotely control optical signals, which customized the secretion of peptides by engineered bacteria. The strategy showed potential in regulating metabolism and improving features in rats and mice models, and the introduction of upconversion microcapsules enhanced the penetrability of the optogenetic system.
