Hypothalamic mechanisms of obesity-associated disturbance of hypothalamic–pituitary–ovarian axis

Leptin and inflammatory factors play a synergistic role in the regulation of reproduction in male mice through hypothalamic kisspeptin-mediated energy balance

(2021) Bo Chang et al.   Reproductive Biology and Endocrinology

Epidemiology and determinants of obesity in China

(2021) Xiong-Fei Pan et al.   Lancet Diabetes & Endocrinology

Effect of neuronal nitric oxide synthase serine-1412 phosphorylation on hypothalamic-pituitary-ovarian function and leptin response

(2020) Damian D Guerra et al.   BIOLOGY OF REPRODUCTION

The effect of excess body fat on female and male reproduction

(2020) Gesthimani Mintziori et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Direct inhibition of arcuate kisspeptin neurones by neuropeptide Y in the male and female mouse

(2020) Sabine Hessler et al.   JOURNAL OF NEUROENDOCRINOLOGY

Brain-specific deletion of TRIM13 promotes metabolic stress-triggered insulin resistance, glucose intolerance, and neuroinflammation

(2020) Yang Qian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypothalamic reproductive neurons communicate through signal transduction to control reproduction

(2020) Emma K. McIlwraith et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

High-Fat Diet Alters LH Secretion and Pulse Frequency in Female Mice in an Estrous Cycle-Dependent Manner

(2020) Ariel L Negrón et al.   ENDOCRINOLOGY

The Association of Serum Levels of Leptin and Ghrelin with the Dietary Fat Content in Non-Obese Women with Polycystic Ovary Syndrome

(2020) Aleksandra Maria Polak et al.   Nutrients

Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment

(2020) Stephanie Constantin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central, but not systemic, thermoregulatory effects of leptin are impaired in rats with obesity: interactions with GABAB agonist and antagonist

(2019) Milen Hristov et al.   AMINO ACIDS

POMC processing in the hypothalamus is directly regulated by saturated fat – implications for the development of obesity

(2019) Daniela S. Razolli et al.   NEUROENDOCRINOLOGY

Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet‐Induced Obese Minipigs

(2019) Alexandra Chmielewski et al.   Obesity

Estradiol Protects Neuropeptide Y/Agouti-related Peptide Neurons against Insulin Resistance in Females

(2019) Jian Qiu et al.   NEUROENDOCRINOLOGY

Diet-induced hypothalamic dysfunction and metabolic disease, and the therapeutic potential of polyphenols

(2019) Ebrahim Samodien et al.   Molecular Metabolism

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

(2019) Shangang Zhao et al.   Cell Metabolism

Role of kisspeptin neurons as a GnRH surge generator: Comparative aspects in rodents and non‐rodent mammals

(2019) Fuko Matsuda et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Attenuation of Inflammation and Leptin Resistance by Pyrogallol-Phloroglucinol-6,6-Bieckol on in the Brain of Obese Animal Models

(2019) Myeongjoo Son et al.   Nutrients

Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?

(2019) Andrea G. Izquierdo et al.   Nutrients

Role of POMC and AgRP neuronal activities on glycaemia in mice

(2019) Aykut Göktürk Üner et al.   Scientific Reports

High-fat diet-induced dysregulation of ovarian gene expression is restored with chronic omega-3 fatty acid supplementation

(2019) Natalie M. Hohos et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Fertility and infertility: Definition and epidemiology

(2018) Mélodie Vander Borght et al.   CLINICAL BIOCHEMISTRY

Is leptin resistance the cause or the consequence of diet-induced obesity?

(2018) Kathy C. G. de Git et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity as disruptor of the female fertility

(2018) Erica Silvestris et al.   Reproductive Biology and Endocrinology

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

(2018) Paul J. Meakin et al.   Scientific Reports

Preoptic leptin signaling modulates energy balance independent of body temperature regulation

(2018) Sangho Yu et al.   eLife

Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence

(2018) Angela K. Odle et al.   Frontiers in Endocrinology

Genetics of Severe Obesity

(2018) Una Fairbrother et al.   Current Diabetes Reports

Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1

(2018) Noah J. Levi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Short-Term High-Fat Diet Increases Leptin Activation of CART Neurons and Advances Puberty in Female Mice

(2017) Jade Cabestre Venancio et al.   ENDOCRINOLOGY

High-Fat Diet and Female Fertility

(2017) Natalie M Hohos et al.   ENDOCRINOLOGY

Obesity and female infertility: potential mediators of obesity's impact

(2017) Darcy E. Broughton et al.   FERTILITY AND STERILITY

How effective are weight-loss interventions for improving fertility in women and men who are overweight or obese? A systematic review and meta-analysis of the evidence

(2017) Damian Best et al.   HUMAN REPRODUCTION UPDATE

Glutamatergic Transmission to Hypothalamic Kisspeptin Neurons Is Differentially Regulated by Estradiol through Estrogen Receptor α in Adult Female Mice

(2017) Luhong Wang et al.   JOURNAL OF NEUROSCIENCE

Melanocortin 4 receptor is not required for estrogenic regulations on energy homeostasis and reproduction

(2017) Pingwen Xu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus

(2017) Konstantina Chachlaki et al.   Nature Reviews Endocrinology

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

AgRP to Kiss1 neuron signaling links nutritional state and fertility

(2017) Stephanie L. Padilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Energy Balance: An Integrated Framework for Discussing Diet and Physical Activity in Obesity Prevention—Is it More than Eating Less and Exercising More?

(2017) Melinda Manore et al.   Nutrients

Hypothalamic Integration of Metabolic, Endocrine, and Circadian Signals in Fish: Involvement in the Control of Food Intake

(2017) María J. Delgado et al.   Frontiers in Neuroscience

Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation

(2017) J.D. Douglass et al.   Molecular Metabolism

Insulin controls food intake and energy balance via NPY neurons

(2017) Kim Loh et al.   Molecular Metabolism

Leptin/leptinR-kisspeptin/kiss1r-GnRH pathway reacting to regulate puberty onset during negative energy balance

(2016) Qianqian Luo et al.   LIFE SCIENCES

A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

(2016) Henning Fenselau et al.   NATURE NEUROSCIENCE

Long-Term High Fat Diet Has a Profound Effect on Body Weight, Hormone Levels, and Estrous Cycle in Mice

(2016) Tandra R. Chakraborty et al.   MEDICAL SCIENCE MONITOR

Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty

(2016) Maria Manfredi-Lozano et al.   Molecular Metabolism

Hypothalamic Inflammation in the Control of Metabolic Function

(2015) Martin Valdearcos et al.   Annual Review of Physiology

Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat Diet–Induced Obesity and Glucose Intolerance

(2015) Jonas Benzler et al.   DIABETES

Positive, But Not Negative Feedback Actions of Estradiol in Adult Female Mice Require Estrogen Receptor α in Kisspeptin Neurons

(2015) Sharon L. Dubois et al.   ENDOCRINOLOGY

Insulin Receptor Signaling in the GnRH Neuron Plays a Role in the Abnormal GnRH Pulsatility of Obese Female Mice

(2015) Sara A. DiVall et al.   PLoS One

Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction

(2014) Nicole Bellefontaine et al.   JOURNAL OF CLINICAL INVESTIGATION

Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction

(2013) Sharone Sheffer-Babila et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cocaine- and Amphetamine-Regulated Transcript Is a Potent Stimulator of GnRH and Kisspeptin Cells and May Contribute to Negative Energy Balance-induced Reproductive Inhibition in Females

(2013) Cadence True et al.   ENDOCRINOLOGY

Free Fatty Acids InduceLhbmRNA but SuppressFshbmRNA in Pituitary LβT2 Gonadotropes and Diet-Induced Obesity Reduces FSH Levels in Male Mice and Disrupts the Proestrous LH/FSH Surge in Female Mice

(2013) Shweta Sharma et al.   ENDOCRINOLOGY

Leptin Signaling in Kiss1 Neurons Arises after Pubertal Development

(2013) Roberta M. Cravo et al.   PLoS One

Effects of Leptin and Melanocortin Signaling Interactions on Pubertal Development and Reproduction

(2012) Davelene D. Israel et al.   ENDOCRINOLOGY

Kisspeptin-GPR54 Signaling in Mouse NO-Synthesizing Neurons Participates in the Hypothalamic Control of Ovulation

(2012) N. K. Hanchate et al.   JOURNAL OF NEUROSCIENCE

Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance

(2012) Rebecca L Leshan et al.   NATURE MEDICINE

Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility

(2012) Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction

(2012) Christa M. Patterson et al.   Molecular Metabolism

Leptin Deficiency and Diet-Induced Obesity Reduce Hypothalamic Kisspeptin Expression in Mice

(2011) Janette H. Quennell et al.   ENDOCRINOLOGY

Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor

(2010) Kathryn J. Brothers et al.   Cell Metabolism

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

(2010) Jennifer W. Hill et al.   Cell Metabolism

Leptin Induces Phosphorylation of Neuronal Nitric Oxide Synthase in Defined Hypothalamic Neurons

(2010) Jose Donato et al.   ENDOCRINOLOGY

Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons

(2010) Jose Donato et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function

(2009) Janette H. Quennell et al.   ENDOCRINOLOGY

Activation of ERβ increases levels of phosphorylated nNOS and NO production through a Src/PI3K/Akt-dependent pathway in hypothalamic neurons

(2008) Sarah Gingerich et al.   NEUROPHARMACOLOGY