Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?

Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

(2019) Martina Theresa Hackl et al.   Nature Communications

Leptin and the maintenance of elevated body weight

(2018) Warren W. Pan et al.   NATURE REVIEWS NEUROSCIENCE

Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

(2018) Maximilian Kleinert et al.   Molecular Metabolism

Fluorescent blood–brain barrier tracing shows intact leptin transport in obese mice

(2018) Luke Harrison et al.   INTERNATIONAL JOURNAL OF OBESITY

Maternal Obesity in the Mouse Compromises the Blood-Brain Barrier in the Arcuate Nucleus of Offspring

(2016) Dong Won Kim et al.   ENDOCRINOLOGY

Hypothalamic leptin action is mediated by histone deacetylase 5

(2016) Dhiraj G. Kabra et al.   Nature Communications

Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice

(2015) Chunling Yan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Diet-Induced Obese Mice Retain Endogenous Leptin Action

(2015) Nickki Ottaway et al.   Cell Metabolism

PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy

(2015) Volker Morath et al.   MOLECULAR PHARMACEUTICS

Peptides and the blood–brain barrier

(2015) William A. Banks   PEPTIDES

Therapeutic potential of flurbiprofen against obesity in mice

(2014) Toru Hosoi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress

(2014) Toru Hosoi et al.   EMBO Molecular Medicine

Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis

(2014) K. Byun et al.   EMBO REPORTS

Endospanin 1 silencing in the hypothalamic arcuate nucleus contributes to sustained weight loss of high fat diet obese mice

(2014) V Vauthier et al.   GENE THERAPY

Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity

(2014) Xiang Yi et al.   JOURNAL OF CONTROLLED RELEASE

GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet

(2013) C. Clemmensen et al.   DIABETES

Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing

(2013) L. De Ceuninck et al.   JOURNAL OF CELL SCIENCE

Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21

(2012) Timo D. Müller et al.   JOURNAL OF PEPTIDE SCIENCE

Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure

(2011) Bart C. De Jonghe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of chronic weight perturbation on energy homeostasis and brain structure in mice

(2011) Y. Ravussin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Intranasal Leptin Reduces Appetite and Induces Weight Loss in Rats with Diet-Induced Obesity (DIO)

(2011) Carla Schulz et al.   ENDOCRINOLOGY

Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway

(2011) Karin Séron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fall in Leptin Concentration Is a Major Determinant of the Metabolic Adaptation Induced by Caloric Restriction Independently of the Changes in Leptin Circadian Rhythms

(2011) Virgile Lecoultre et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

Transport across the Blood-Brain Barrier of Pluronic Leptin

(2010) T. O. Price et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of PTP1B by Trodusquemine (MSI-1436) Causes Fat-specific Weight Loss in Diet-induced Obese Mice

(2010) Kristen A. Lantz et al.   Obesity

The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid

(2010) Esteban M. Rodríguez et al.   PEPTIDES

Multi-hormonal weight loss combinations in diet-induced obese rats: Therapeutic potential of cholecystokinin?

(2010) James L. Trevaskis et al.   PHYSIOLOGY & BEHAVIOR

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Leptin-based glycopeptide induces weight loss and simultaneously restores fertility in animal models

(2009) I. Kovalszky et al.   DIABETES OBESITY & METABOLISM

Pegylated Leptin Antagonist Is a Potent Orexigenic Agent: Preparation and Mechanism of Activity

(2009) Eran Elinav et al.   ENDOCRINOLOGY

Tat-modified Leptin is more Accessible to Hypothalamus through Brain-blood Barrier with a Significant Inhibition of Body-weight Gain in High-fat-diet Fed Mice

(2009) C. Zhang et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

(2009) Seongjin Seo et al.   HUMAN MOLECULAR GENETICS

Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy

(2009) Eric Ravussin et al.   Obesity

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

(2009) Juliana C. Moraes et al.   PLoS One

Astrocyte Leptin Receptor (ObR) and Leptin Transport in Adult-Onset Obese Mice

(2008) Weihong Pan et al.   ENDOCRINOLOGY

Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli

(2008) Michael Rosenbaum et al.   JOURNAL OF CLINICAL INVESTIGATION