Article
Oncology
Moran Yang, Jiaqi Lu, Guodong Zhang, Yiying Wang, Mengdi He, Qing Xu, Congjian Xu, Haiou Liu
Summary: This study reveals the critical role of CXCL13 in shaping the antitumor microenvironment by facilitating the maintenance of CXCR5(+)CD8(+) T cells in TLSs, and supports a clinical investigation for a combination of CXCL13 and PD-1 blockade therapy in HGSC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Xiaoyan Sun, Weiran Liu, Leina Sun, Huilan Mo, Yingnan Feng, Xinyi Wu, Chenguang Li, Chen Chen, Jingjing Li, Ying Xin, Zhenfa Zhang, Changli Wang, Bin Zhang, Dongsheng Yue
Summary: This study investigated the maturation and abundance of tertiary lymphoid structures (TLS) in resectable non-small cell lung cancer (NSCLC) patients receiving neoadjuvant treatments, and found that the maturation of TLS is associated with treatment response and patient prognosis. The neoadjuvant chemoimmunotherapy group showed the highest TLS maturation and abundance, as well as higher rates of major pathological response (MPR) and pathological complete response (pCR). The maturation and abundance of TLS were significantly correlated with MPR and disease-free survival (DFS), and were independent predictors for DFS.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Pharmacology & Pharmacy
Claire L. Ihle, Sabrina J. Wright-Hobart, Philip Owens
Summary: The survival rate of breast cancer patients has improved, but metastatic breast cancer still causes high mortality. Metastasis mainly occurs in the bone, and current treatment methods focus on palliative care and slowing down the progression. Recent advances in molecularly targeted agents have made breakthroughs in the treatment of metastatic breast cancer, but immunotherapies have not been fully applied in estrogen receptor-positive tumors. Therapeutic approaches targeting the bone microenvironment of metastatic breast cancer have potential applications in other bone-resident cancers.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Chunyang Jiang, Xu Li, Bingsheng Sun, Na Zhang, Jing Li, Shijing Yue, Xiaoli Hu
Summary: This study demonstrates the role of ALAHM in tumor-derived extracellular vesicles (EVs) in promoting liver metastasis of lung adenocarcinoma (LUAD) cells. ALAHM enhances the proliferation, invasion, and migration of LUAD cells, and induces hepatocyte secretion of HGF. The findings suggest that LUAD-cell-derived EVs containing ALAHM contribute to the progression of liver metastasis in LUAD.
Article
Oncology
Xiaofeng Chen, Deqiang Wang, Jing Liu, Jingrong Qiu, Jun Zhou, Jieer Ying, Yan Shi, Zhaoxia Wang, Haizhou Lou, Jiuwei Cui, Jingdong Zhang, Yunpeng Liu, Fengjiao Zhao, Lanlan Pan, Jianyi Zhao, Dongqin Zhu, Shiqing Chen, Xiangcheng Li, Xue Li, Liuqing Zhu, Yang Shao, Yongqian Shu
Summary: This study found that KRAS and TP53 mutations are more frequent in advanced BTC, with KRAS-TP53 co-mutations associated with a favorable response to immunotherapy. Compared to GBC, CHOL has more mutations in genes involved in KRAS signaling, potentially leading to inferior immunotherapy outcomes. Additionally, a genomic signature including 11 genes was developed to predict prognosis and immunotherapy outcomes in CHOL and GBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Xiaofang Xing, Jinyao Shi, Yongning Jia, Yunsheng Dou, Zhongwu Li, Bin Dong, Ting Guo, Xiaojing Cheng, Xiaomei Li, Hong Du, Ying Hu, Shuqin Jia, Jian Zhang, Ziyu Li, Jiafu Ji
Summary: The study provides insights into the immune modulation effect of chemotherapy in gastric cancer, suggesting that the immune profile of specimens after standard chemotherapy should be considered for personalized immunotherapy to improve clinical outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Lenka N. C. Boyd, Katarina D. Andini, Godefridus J. Peters, Geert Kazemier, Elisa Giovannetti
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a poor prognosis. The tumor microenvironment (TME) of PDAC, characterized by cancer-associated fibroblasts (CAFs), plays a dual role in tumor progression. Understanding the heterogeneity and plasticity of CAFs, as well as their behavior during PDAC progression, is crucial for improving therapeutic strategies for PDAC patients.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Chemistry, Physical
Shi He, Xinyu Gou, Shuheng Zhang, Xifeng Zhang, Hongyi Huang, Wanyu Wang, Linbin Yi, Rui Zhang, Zhongxin Duan, Peizhi Zhou, Zhiyong Qian, Xiang Gao
Summary: This review summarizes the research progress and prospects of nanodelivery systems for overcoming tumor resistance, highlighting the promising strategy of targeting tumor resistance mechanisms to improve therapeutic efficacy. Nanodelivery systems with precise targeting and drug release capabilities offer hope for overcoming cancer resistance.
Review
Pharmacology & Pharmacy
Adeeb Shehzad, Salman Ul Islam, Raheem Shahzad, Salman Khan, Young Sup Lee
Summary: Cell-to-cell interactions within the tumor microenvironment play a crucial role in cancer promotion, development, and malignant transformation. Extracellular vesicles (EVs), including exosomes and microvesicles, mediate the transportation of regulatory molecules between cells and to distant sites, contributing to the formation of premetastatic niches and the progression of malignancies. EVs have potential applications in disease diagnosis, prognosis, and therapeutics in the field of cancer research.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Oncology
Qiangda Chen, Hanlin Yin, Siyao Liu, Sami Shoucair, Ni Ding, Yuan Ji, Jicheng Zhang, Dansong Wang, Tiantao Kuang, Xuefeng Xu, Jun Yu, Wenchuan Wu, Ning Pu, Wenhui Lou
Summary: Tumor-associated N2 neutrophils were found to significantly increase, while a low N1/N2 ratio was associated with poorly differentiated tumors, easier lymph node metastases, and higher TNM stage. A high N1/N2 ratio was identified as a significant prognostic indicator for overall survival and recurrence-free survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Medicine, Research & Experimental
Ankit Banik, Rishika Sharma, Akansha Chauhan, Sandhya Singh
Summary: This article reviews the recent therapeutics developed to target cancer stem cells (CSCs) through multiple signaling cascades, altered metabolism, and the tumor microenvironment. It discusses the functioning of CSCs and their interaction with different cells in the tumor microenvironment, as well as possible strategies to disrupt this interaction for better treatment outcomes.
Article
Oncology
Quentin Klopfenstein, Valentin Derangere, Laurent Arnould, Marion Thibaudin, Emeric Limagne, Francois Ghiringhelli, Caroline Truntzer, Sylvain Ladoire
Summary: The prognosis of early breast cancer is associated with the clinic-pathological stage and the molecular characteristics of tumor cells. In some patients, the presence of tumor-infiltrating immune cells can impact long term outcome. A new gene expression deconvolution algorithm was developed to estimate immune cell populations in tumors and found that myeloid cells were associated with poor outcomes, while lymphoid cells were linked to favorable prognosis. This information, when combined with clinical stage and PAM50, can improve the prediction of relapse or death in early breast cancer patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Cell Biology
Longfei Deng, Nianfen Jiang, Jun Zeng, Yi Wang, Hongjuan Cui
Summary: CAFs play a critical role in the tumor microenvironment and significantly impact the treatment of CRC, but their therapeutic potential is hindered by limited understanding of their heterogeneity in origins, functions, and mechanisms. Recent studies have identified cellular precursors and molecular markers of CAFs, revealing their versatility and potential for targeted therapy in CRC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Kunpeng Lv, Mengyao Sun, Hanji Fang, Jieti Wang, Chao Lin, Hao Liu, Heng Zhang, He Li, Hongyong He, Yun Gu, Ruochen Li, Fei Shao, Jiejie Xu
Summary: In gastric cancer, Siglec-10 positive tumor-associated macrophages (TAMs) contribute to immune evasion by exhibiting an immunosuppressive phenotype and hindering CD8+ T cell-mediated antitumor immune response. Blocking Siglec-10 can reinvigorate the antitumor immune response and synergistically enhance the efficacy of anti-PD-1 immunotherapy in an ex vivo gastric cancer tumor fragment platform.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Zhijun Zhou, Anuj K. Saluja, Courtney W. Houchen, Min Li
Summary: Replication stress is a prominent feature of tumor cells and plays a crucial role in maintaining genomic integrity. This study establishes a novel biomarker, REST18, based on 18 replication-stress associated genes, which can indicate prognosis and treatment response of chemotherapy in pancreatic cancer.
Review
Biochemical Research Methods
Juan Guo, Xueting Pan, Chaohui Wang, Huiyu Liu
Summary: This review focuses on molecular imaging-guided sonodynamic therapy (SDT), discussing the mechanisms of SDT, major molecular imaging techniques, and design principles based on nanoparticles. Furthermore, it summarizes the applications of imaging-guided SDT in cancer treatment, bacterial infections, and vascular diseases.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shanshan Li, Bolong Xu, Mingzhu Lu, Mengxue Sun, Haokun Yang, Shuang Liu, Zhijun Huang, Huiyu Liu
Summary: Surface reconstruction and lattice tensile strain are utilized to activate the inactive facets of palladium nanosheets, leading to the development of strained palladium nanosheets with photodynamic, catalase-like, and peroxidase-like properties. These strained nanosheets exhibit higher tumor inhibition rate compared to the original palladium nanosheets.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Mingzhu Lu, Shanshan Li, Xiaolu Xiong, Zhijun Huang, Bolong Xu, Yunhang Liu, Qingyuan Wu, Nier Wu, Huiyu Liu, Dongsheng Zhou
Summary: In this study, a manganese-doped dopamine-derived hollow carbon sphere is developed as a nanozyme and photothermal agent for the synergistic treatment of multi-drug resistant bacterial infections. It exhibits multiple enzymatic activities and utilizes near-infrared light to enhance its catalytic and therapeutic effects, showing a broad-spectrum synergistic antibacterial efficiency against multi-drug resistant pathogens.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Chemistry, Physical
Xiaozhou Mou, Qingyuan Wu, Zheao Zhang, Yunhang Liu, Jungang Zhang, Chengwu Zhang, Xiaoyi Chen, Kelong Fan, Huiyu Liu
Summary: This review summarizes the application potentials and recent advances of nanozymes in regeneration medicine, including catalytic mechanisms, strategies to improve biocompatibility, and applications in various fields of tissue regeneration medicine.
Review
Chemistry, Multidisciplinary
Bolong Xu, Zhijun Huang, Yunhang Liu, Shanshan Li, Huiyu Liu
Summary: Nanomedicines with chemical activity have great potential as therapeutic agents in various biomedical fields. The idea of bioinspired design has provided guidance for designing and manufacturing nanomedicines with high chemical activity and desired therapeutic outcomes. This review focuses on nanomedicines inspired by structures of natural active components, with a particular emphasis on the recent development of metal-organic framework (MOF)-based bioinspired nanomedicines.
Article
Chemistry, Multidisciplinary
Shuang Liu, Tianshu Zhang, Shanshan Li, Qingyuan Wu, Kexin Wang, Xican Xu, MingZhu Lu, Rongguang Shao, Wuli Zhao, Huiyu Liu
Summary: This study reports a nanotherapeutic strategy based on MnOx-loaded polydopamine (MnOx/PDA) nanobombs with chemodynamic, photodynamic, photothermal, and biodegradation properties to simultaneously inhibit cancer stem cells (CSCs) and non-CSCs. The MnOx/PDA nanobombs can directly disrupt the microenvironment and tumorigenic capacity of CSCs by generating hyperthermia, oxidative stress, and alleviating hypoxia. Additionally, they can directly ablate the bulk tumor cells, cutting off the supply of CSCs transformation. The synergistic therapy achieved a tumor inhibition rate of 70.8% in a colorectal cancer (CRC) model.
Article
Chemistry, Multidisciplinary
Mengxue Sun, Meichen Yang, Shanshan Li, Chaohui Wang, Fengrong Zhang, Bolong Xu, Yulian Zhang, Xinxiao Sun, Qipeng Yuan, Huiyu Liu
Summary: A novel light-controlled engineered bacterial material is developed for synergistic regulation of amino acid metabolism to combat tumors. In vitro and in vivo experiments demonstrate that this method effectively inhibits tumor growth and induces apoptosis of tumor cells. This strategy provides new ideas for the combination of synthetic biology and nanotechnology in anti-tumor therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mengya He, Xican Xu, Hongyu Wang, Qingyuan Wu, Linghao Zhang, Dongsheng Zhou, Yigang Tong, Xin Su, Huiyu Liu
Summary: A cut-price colorimetric method using iron manganese silicate nanozyme (IMSN) has been developed for detecting SARS-CoV-2 RNA. This method catalyzes the oxidation of chromogenic substrates by the peroxidase-like activity of IMSN, which is inhibited by pyrophosphate ions (PPi). With a detection limit of 240 copies mL(-1), SARS-CoV-2 RNA can be detected by a colorimetric readout visible to the naked eye. This low-cost and instrumental-free approach has been successfully applied to differentiate positive and negative oropharyngeal swab samples of COVID-19 patients.
Article
Chemistry, Multidisciplinary
Xuan Ouyang, Xican Xu, Qingqing Qin, Chenxi Dai, Hongyu Wang, Shuang Liu, Lingfei Hu, Xiaolu Xiong, Huiyu Liu, Dongsheng Zhou
Summary: Bacterial pneumonia is a leading cause of death worldwide. Current vaccines have limitations, so there is a need to develop next-generation vaccines. This study developed a novel nanoparticle vaccine that effectively prevents pneumonic plague.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shuncheng Yao, Qingyuan Wu, Shaobo Wang, Yunchao Zhao, Zhuo Wang, Quanhong Hu, Linlin Li, Huiyu Liu
Summary: A self-driven electrical stimulation system is constructed to enhance the cascade catalytic activity of alloy nanoparticles (ANs) for cancer therapy. When delivering the electric stimulation to AuPd ANs through a triboelectric nanogenerator, multiple catalytic activities are substantially improved, forming proper cascade reactions to boost the final production of free radicals and improve therapeutic outcomes.
Article
Chemistry, Multidisciplinary
Qingyuan Wu, Jie Zhang, Xueting Pan, Zhijun Huang, Haoyuan Zhang, Juan Guo, Yun Xue, Rui Shi, Huiyu Liu
Summary: Sonodynamic therapy (SDT) is a noninvasive and high-penetration therapy for cancer, but the design of an efficient sonosensitizer is still lacking. Researchers have designed molybdenum disulfide nanoflowers (MoS2 NF) as piezo-sonosensitizers and introduced sulfur vacancies on the MoS2 NF (Sv-MoS2 NF) to improve their piezoelectric property for cancer therapy. Under ultrasonic mechanical stress, the Sv-MoS2 NF exhibited enhanced piezoelectric polarization and band tilting, leading to improved charge carrier separation and migration, resulting in enhanced reactive oxygen species (ROS) production and ultimately improved SDT performance. The Sv-MoS2 NF demonstrated a promising anticancer effect in vitro and in vivo, and also showed good biocompatibility.
Article
Chemistry, Multidisciplinary
Shanshan Li, Bolong Xu, Haokun Yang, Chong Zhang, Jiali Chen, Shuang Liu, Zhijun Huang, Huiyu Liu
Summary: This paper reports a biodegradable Pt1Pd single-atom alloy nanozyme, which exhibits enzyme-like catalytic performance and photodynamic effect. The introduction of single-atom Pt sites is proven to enhance its catalytic efficiency towards substrates, resulting in photo-controlled therapeutic effects.
Review
Biochemistry & Molecular Biology
Bolong Xu, Shanshan Li, Rui Shi, Huiyu Liu
Summary: Mesoporous silica nanoparticles (MSNs) have great potential in the biomedical field, with their easily tunable structure and composition, diverse surface functionalization properties, and excellent biocompatibility. This review provides a comprehensive summary of the development history, nanostructured architectures, and surface functionalization of MSNs, as well as their biomedical applications and progress in clinical trials. The future direction and challenges of MSNs in the biomedical field are also discussed.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Chemistry, Physical
Xican Xu, Jin Zhang, Shuang Liu, Chaohui Wang, Hongyu Wang, Huahao Fan, Yigang Tong, Huiyu Liu, Dongsheng Zhou
Summary: This article summarizes the recent advances in nanomaterial-based antiviral strategies, including antiviral nanodrugs, drug nanocarriers, and nanovaccines, and discusses the clinical challenges and prospects of these strategies.