Review
Engineering, Biomedical
Arezoo Esrafili, Avery Wagner, Sahil Inamdar, Abhinav P. Acharya
Summary: Covalent organic frameworks (COFs) are porous organic polymeric materials with desirable properties like high stability, low density, and large surface area, making them suitable for applications in the energy sector and drug delivery. This review discusses different types of COFs, synthesis methods, and their potential applications in the biomedical field, highlighting the specific advantages that can be utilized for specialized biomedical applications such as immune engineering.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Alvaro Carcamo-Martinez, Bronach Mallon, Juan Dominguez-Robles, Lalitkumar K. Vora, Qonita K. Anjani, Ryan F. Donnelly
Summary: Microneedles have the potential to be a highly progressive device for drug delivery and monitoring purposes by penetrating the skin and piercing the stratum corneum barrier. Hollow microneedles have entered the pharmaceutical market as medical devices, with continuous development in materials and methods for fabrication, and expanding applications in drug delivery, vaccine delivery, and monitoring.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Lijuan Wang, Yushuang Shang, Jie Zhang, Jiang Yuan, Jian Shen
Summary: The development of keratin-based biomaterials provides a valuable approach for addressing environmental pollutants and transforming waste into wealth. The properties and biomedical applications of keratin biomaterials, such as drug delivery, wound healing, and tissue engineering, are extensively discussed in this review, offering valuable insights for further research and development.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Hossein Omidian, Sumana Dey Chowdhury, Niloofar Babanejad
Summary: Cryogels, versatile biomaterials composed of synthetic and natural materials, have wide applications in tissue engineering, drug delivery, regenerative medicine, and therapeutics. However, optimizing cryogel properties remains challenging, and researchers are exploring advanced manufacturing techniques and addressing long-term stability. Combination therapies and drug delivery systems using cryogels show promise, but in vivo evaluation and clinical trials are crucial for determining safety and efficacy. Overcoming practical challenges such as scalability, structural integrity, mass transfer constraints, biocompatibility, seamless integration, and cost-effectiveness is essential for the successful application of cryogels in biomedical fields.
Review
Pharmacology & Pharmacy
Sairish Malik, Sundarrajan Subramanian, Tanveer Hussain, Ahsan Nazir, Seeram Ramakrishna
Summary: This paper highlights the importance and potential role of electrosprayed nanoparticles in biomedical applications through a literature review. Electrosprayed nanoparticles offer unique advantages and can be used in drug delivery systems to improve drug efficacy and reduce side effects.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Biochemistry & Molecular Biology
Sara La Manna, Concetta Di Natale, Valentina Onesto, Daniela Marasco
Summary: Self-assembling peptides are a novel class of agents with versatile applications in the biomedical field. They exhibit biocompatibility and molecular recognition capabilities, making them suitable for drug delivery and tissue engineering purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yang Gao, Qingming Ma, Jie Cao, Yiwen Wang, Xin Yang, Qiulong Xu, Qing Liang, Yong Sun
Summary: The review highlights the recent progress in fabricating chitosan-based biomaterials using microfluidic technology, emphasizing the precise control over morphology and microstructures, as well as the potential applications of chitosan-based materials in the field of biomedicine.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Yu Chen, Samira Pal, Quanyin Hu
Summary: Relay delivery strategy is a two-step targeting approach that artificially creates a target/environment for subsequent effectors, amplifying targeted signals at the disease site. Cell-based therapeutics, with their inherent homing abilities and feasibility of modifications, serve as excellent candidates in relay delivery strategies. In this review, recent advances in relay delivery systems are surveyed, with a specific focus on the roles of various cells.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Applied
Ameya Sharma, Ishnoor Kaur, Divya Dheer, Manju Nagpal, Pradeep Kumar, D. Nagasamy Venkatesh, Vivek Puri, Inderbir Singh
Summary: Numerous compounds in the oceans have extensive applications in biomedical and biotechnological fields, which make them a prime renewable source of natural substances and promote the development of novel medical systems and devices. Polysaccharides, abundantly present in the marine ecosystem, have advantages such as low extraction costs, solubility in extraction media, interactions with biological compounds, and the ability to be modified for various shapes and sizes. These properties have led to their use as raw materials for drug delivery carrier systems.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Biomedical
Cho-E Choi, Aishik Chakraborty, Ali Coyle, Yasmeen Shamiya, Arghya Paul
Summary: Considerable progress has been made in synthesizing intelligent, biodegradable hydrogels that undergo rapid changes in physicochemical properties once exposed to external stimuli. These advantageous properties of stimulus-triggered materials make them highly appealing to diverse biomedical applications. Of late, research on the incorporation of light-triggered nanoparticles (NPs) into polymeric hydrogel networks has gained momentum due to their ability to remotely tune hydrogel properties using facile, contact-free approaches, such as adjustment of wavelength and intensity of light source.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Farzad Seidi, Mohsen Khodadadi Yazdi, Maryam Jouyandeh, Midhun Dominic, Haleh Naeim, Mojtaba Nasiri Nezhad, Babak Bagheri, Sajjad Habibzadeh, Payam Zarrintaj, Mohammad Reza Saeb, Masoud Mozafari
Summary: Polysaccharides are abundant carbohydrate polymers, with chitosan being the most widely used; blending chitosan with other polymers can improve its properties and bioactivity. This review paper summarizes progress in chitosan blends with biodegradable polymers and polysaccharides for biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Materials Science, Biomaterials
Indra J. Budiarso, Novi D. W. Rini, Annisa Tsalsabila, Muhammad D. Birowosuto, Arie Wibowo
Summary: Over the past decade, smart and functional biomaterials have become one of the most rapidly emerging fields in life sciences due to their potential to improve biomaterial performance through their interaction and response with living systems. Chitosan, with its beneficial properties such as biodegradability, hemostatic and antibacterial activity, biocompatibility, and versatility, plays a crucial role in this field. This review provides an up-to-date development of various structures of chitosan-based smart biomaterials and highlights their applications in the biomedical field, specifically in drug delivery systems, bone scaffolds, wound healing, and dentistry.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Engineering, Biomedical
Sarah J. Shepherd, David Issadore, Michael J. Mitchell
Summary: Nanomedicine has advanced significantly in clinical applications, with microfluidic devices showing potential for generating reproducible nanoparticle formulations. These formulations enhance biomedical applications with controlled physical properties, pointing towards future production scale-independent formulations through parallelization and multi-step reactions.
Review
Biochemistry & Molecular Biology
Marcin Sobczak, Karolina Kedra
Summary: With the development of polymeric biomaterials, drug delivery systems (DDSs) have become crucial in cancer therapy. Polyurethanes (PUs) are widely used in medicine and biomaterial engineering, and can be synthesized for anti-cancer DDSs by selecting suitable building blocks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Applied
Masoud Hamidi, Oseweuba Valentine Okoro, Peiman Brouki Milan, Mohammad Reza Khalili, Hadi Samadian, Lei Nie, Amin Shavandi
Summary: Fungal exopolysaccharides have diverse potential applications in various industries. However, there are only a few commercialized products based on fungal EPSs in the biomedical field. This review critically discusses the potential biomedical applications of fungal EPSs in tissue engineering, drug and gene delivery.
CARBOHYDRATE POLYMERS
(2022)
Article
Biotechnology & Applied Microbiology
Peizhou Chen, Christopher Ference, Xiuxiu Sun, Ying Lin, Lianjiang Tan, Tian Zhong
JOURNAL OF FOOD PROTECTION
(2020)
Article
Biochemistry & Molecular Biology
Tao Jiang, Liang Wang, Angjie Ma, Yi Wu, Qiwen Wu, Qiulin Wu, Jianwei Lu, Tian Zhong
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Article
Plant Sciences
Tian Zhong, Jiuxu Zhang, Xiuxiu Sun, Jingjing Kou, Zhike Zhang, Jinhe Bai, Mark A. Ritenour
Summary: The study found that using ClO2 gas technology can effectively control postharvest stem-end rot of citrus, especially when ClO2 treatment is initiated 0 to 6 hours after inoculation.
Article
Food Science & Technology
Ying Lin, Ran Huang, Xiuxiu Sun, Xi Yu, Ying Xiao, Ling Wang, Wenzhong Hu, Tian Zhong
Summary: The inclusion complexes prepared using co-precipitation method showed promising results for food preservation, with improved physical properties, antioxidant activity, and inhibition of bacterial growth. Comparing with pure PAA, the complexes demonstrated superior storage stability and equal efficacy against Escherichia coli and Staphylococcus aureus.
Article
Polymer Science
Yuanbao Jin, Liying Wang, Yumeng Liu, Xiaomei Liu, Tian Zhong
Summary: Amphiphilic floxuridine-poly epsilon-caprolactone conjugates were synthesized and self-assembled with phenylsulfonyl furoxan to form drug-loading micelles, which released chemotherapeutic drug FdU and NO in cancer cells synergistically. This drug-polymer conjugate-based micelles showed high therapeutic efficacy for cancer with low side effects, providing a new approach to cancer chemotherapy.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Food Science & Technology
Ying Lin, Ran Huang, Xiuxiu Sun, Xi Yu, Ying Xiao, Ling Wang, Wenzhong Hu, Tian Zhong
Summary: The developed beta-cyclodextrin/p-Anisaldehyde inclusion complexes showed inhibitory effects on fungal growth and effectively controlled postharvest decay in strawberries. Fruit quality and sensory attributes were not significantly affected by the inclusion complexes treatment.
Article
Orthopedics
Zhao-lin Teng, Xiong-gang Yang, Xiang Geng, Yan-jie Gu, Ran Huang, Wen-ming Chen, Chen Wang, Li Chen, Chao Zhang, Maimaitirexiati Helili, Jia-zhang Huang, Xu Wang, Xin Ma
Summary: This study developed a novel dynamic measurement technique to test the material properties and investigate the effect of continuous compression load on the structural and mechanical properties of the human heel pad during actual gait. The results showed that repetitive loading decreased the primary thickness and viscous modulus of the heel pad, while age was negatively correlated with the primary thickness and peak strain, and positively correlated with the viscous modulus.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Endocrinology & Metabolism
Xiong-gang Yang, Zhao-lin Teng, Zhen-ming Zhang, Kan Wang, Ran Huang, Wen-ming Chen, Chen Wang, Li Chen, Chao Zhang, Jia-zhang Huang, Xu Wang, Xin Ma, Xiang Geng
Summary: This study compared the material properties of heel pad between diabetes patients and healthy adults, and investigated the impact of compressive loading history and length of diabetes course on the material properties of heel pad. The results showed significant differences in material properties between diabetes patients and healthy adults.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Food Science & Technology
Yujia Zhang, Jiafan Qiu, Kewen Yang, Yuting Lu, Zixian Xu, Huanqi Yang, Yuqing Xu, Letao Wang, Yu Lin, Xinyang Tong, Junge He, Ying Xiao, Xiuxiu Sun, Ran Huang, Xi Yu, Tian Zhong
Summary: Food preservation is crucial for ensuring food safety and quality. Gaseous ClO2 has gained attention as an effective and eco-friendly preservation technique, with strong oxidizing properties and high efficacy in inactivating microorganisms. However, challenges such as large-scale generation, cost, and environmental considerations limit its widespread use in the food industry. This review provides an overview of the research on gaseous ClO2, including preparation methods, preservation mechanisms, and predictive kinetic models. It also summarizes the impact of gaseous ClO2 on the quality of fresh produce and low-moisture foods. Future studies should focus on addressing the challenges and developing standardized protocols and databases for its safe and effective use.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Article
Food Science & Technology
Anyu Wang, Xiao Feng, Guangyun He, Ying Xiao, Tian Zhong, Xi Yu
Summary: Food safety issues are a global concern, and traditional detection methods cannot meet the demands for timely and accurate food safety detection due to their limitations. Digital microfluidic chips offer a promising solution with their ultra-high sensitivity, wide applicability, and real-time detection capabilities.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Food Science & Technology
Xiaohan Zhao, Xiao Feng, Jingwen Chen, Lanxin Zhang, Lingzi Zhai, Sizhe Lv, Yonghao Ye, Yongqi Chen, Tian Zhong, Xi Yu, Ying Xiao
Summary: A rapid and efficient method using alkyl-functionalized magnetic nanoparticles-based extraction technique combined with Ultra-High Performance Liquid Chromatography was developed for detecting trace amounts of polycyclic aromatic hydrocarbons in tea leaves. The C-18-alkyl coating was found to be effective in separating polycyclic aromatic hydrocarbons. The magnetism of the nanomaterials accelerated the extraction process while their high surface ratio enabled desirable dispersity in the sample matrix. Moreover, the adsorbents can be washed and reused 30 times without compromising recovery, greatly reducing the budget.
Article
Biochemistry & Molecular Biology
Yao Liu, Caijiao Wei, Hui Wan, Sarengaowa Sarengaowa, Xiaoping Liang, Tao Jiang, Yuhe Dong, Xihong Zhao, Tian Zhong
Summary: A rapid and practical technique (PMA-mPCR) was developed for the simultaneous detection of viable E. coli O157:H7, S. aureus, and Salmonella in pure culture and in a food matrix. The use of propidium monoazide (PMA) at an optimum concentration of 5.0 μg/mL successfully eliminated false positive results. The PMA-mPCR assay showed a detection limit of 10(4) CFU/mL for both pure culture and food matrix samples.
Article
Polymer Science
Xiaoyan He, Lisheng Tang, Jun Zheng, Yuanyuan Jin, Ruobin Chang, Xiaoquan Yu, Yihu Song, Ran Huang
Summary: Cellulose was extracted from coconut shell powder and used as a reinforcing material in PLA/PBS films. The extracted cellulose showed improved thermal stability and higher crystallinity compared to the raw coconut shell powder.
Article
Food Science & Technology
Yao Liu, Lvzhou Zhu, Xi Yu, Yuqing Xu, Tian Zhong
Summary: This study develops a new ultrasound-microwave assisted method to improve the solubility of granulated cold-water-soluble starch. The optimized parameters and proportions are determined through single-factor and orthogonal experiments. The results show that this method significantly improves the solubility of modified starch.
