Review
Oncology
Maxime Loo, Jean-Baptiste Clavier, Justine Attal Khalifa, Elisabeth Moyal, Jonathan Khalifa
Summary: Brain metastases are a common complication for cancer patients, with stereotactic radiosurgery considered a cornerstone treatment. The ideal dose and fractionation schedule remain unknown, with ongoing debates regarding the use of hypofractionated schedules and the linear-quadratic model. Recent studies have shown the importance of radiation schedule in immunomodulatory responses. Efficacy and toxicity data suggest that hypofractionated schedules may offer benefits in terms of reducing toxicity and improving local control rates compared to single-fraction treatment.
Article
Biochemistry & Molecular Biology
Hideaki Kawabata, Takashi Fujii, Tetsuya Yamamoto, Hiroaki Satake, Katsutoshi Yamaguchi, Yuji Okazaki, Kojiro Nakase, Masatoshi Miyata, Shigehiro Motoi
Summary: This study retrospectively reviewed the efficacy of radiotherapy for bleeding gastric cancer patients, showing a high success rate but also indicating potential risks.
Review
Radiology, Nuclear Medicine & Medical Imaging
Daniela Alterio, Mattia Zaffaroni, Paolo Bossi, Francesco Dionisi, Olgun Elicin, Andrea Falzone, Annamaria Ferrari, Barbara Alicja Jereczek-Fossa, Giuseppe Sanguineti, Petr Szturz, Stefania Volpe, Melissa Scricciolo
Summary: This study reviewed the literature on modern radiation techniques and fractionations used for reirradiation of local recurrent/second primary tumors of the head and neck. Based on the literature data, a stepwise approach was proposed to select patients for curative reirradiation. Two clinical cases were provided for application of this approach.
Article
Oncology
Mateusz Jacek Spalek, Tomasz Mandat
Summary: Brain metastases are common in patients with breast cancer, with treatment options including surgery and radiotherapy. However, some patients may still experience intracranial progression despite local treatment. The choice of optimal treatment methods should take into consideration various factors such as patient performance status, cancer burden, toxicity, and previous therapies.
Review
Oncology
Francois Lucia, Ruben Touati, Nicolae Crainic, Gurvan Dissaux, Olivier Pradier, Vincent Bourbonne, Ulrike Schick
Summary: Approximately 30% of cancer patients will develop brain metastases, leading to local recurrence post intracranial stereotactic radiotherapy. Advances in cancer treatments have increased overall survival, but also local failures (LF) after SRS/SRT. Second courses of SRS or SRT may be used to treat LF, with factors affecting efficacy including histology, tumor size, and prior treatments. Prospective studies with more patients are needed to determine the best management of brain metastases recurrence.
Article
Oncology
Minmin Li, Yanbo Song, Longhao Li, Jian Qin, Hongbin Deng, Tao Zhang
Summary: The case report presented a patient with multiple BMs of NSCLC, who received two courses of WBRT and one course of GK radiotherapy over 5 years. The patient survived for 12 years with good tumor response to each radiotherapy, maintaining a high quality of life throughout the survival period.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Janet E. Squires, Sarah Asad, Melissa Demery Varin, Kristin Dennis, Edward Chow, Alysa Fairchild, Rebecca Wong, Ian D. Graham, Jeremy M. Grimshaw, Kristopher Dennis
Summary: This study explored the behavioral determinants of Canadian radiation oncologists' use of SFRT for uncomplicated bone metastases using the Theoretical Domains Framework (TDF). The results identified factors that encourage and discourage the use of SFRT, with most radiation oncologists being aware of evidence and guidelines on SFRT, while the higher risk of retreatment was identified as a major barrier. Experience and convenience were found to be facilitators for SFRT use.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
V Batumalai, J. Descallar, G. P. Delaney, G. Gabriel, K. Wong, J. Shafiq, S. K. Vinod, M. B. Barton
Summary: The study found that single-fraction radiation therapy (SFRT) is underused for the treatment of bone metastases in New South Wales, Australia, with a higher 30-day mortality rate compared to multi-fraction radiation therapy (MFRT). Older patients, those with lower socioeconomic status, residing in outer regional areas, or with multiple comorbidities were more likely to receive SFRT. This indicates a need to increase the utilization of SFRT for bone metastases treatment.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Rossella Di Franco, Donato Pezzulla, Fabio Arcidiacono, Antonio Pontoriero, Francesco Cellini, Liliana Belgioia, Valentina Borzillo, Sara Lillo, Francesco Pastore, Luca Dominici, Silvia Longo, Alberto Cacciola, Antonella Ciabattoni, Alice Zamagni, Giulio Francolini, Antonella Fontana, Esmeralda Scipilliti, Rosario Mazzola, Elisa D'Angelo, Rossana Ingargiola, Paolo Muto, Ernesto Maranzano
Summary: This survey provides insights into the treatment choices and factors considered by radiation oncologists in Italy for patients with spinal metastases, with a specific focus on reirradiation. Palliative radiotherapy remains a field of interest, with traditional techniques being preferred for patients with shorter life expectancy and newer technologies for those with longer life expectancy. Factors such as time between treatments, dose delivered, vertebral stability, symptoms, and performance status are taken into consideration for retreatment decisions. The most feared complications are myelopathy and vertebral fractures.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
R. Kinj, J. Doyen, J. M. Hannoun-Levi, A. O. Naghavi, M. E. Chand, G. Baudin, J. M. Ferrero, E. Francois, L. Evesque, D. Borchiellini, K. Benezery, P. Y. Bondiau
Summary: This study evaluated the outcomes of SBRT reirradiation for extraosseous recurrences in the pelvis, showing it to be a safe and effective treatment modality. Improved local control was associated with smaller tumour volume and primary prostate location.
Article
Oncology
Laure Kuntz, Clara Le Fevre, Delphine Jarnet, Audrey Keller, Philippe Meyer, Christophe Mazzara, Helene Cebula, Georges Noel, Delphine Antoni
Summary: This retrospective study analyzed the data of patients who received at least two courses of SRT between 2010 and 2020. The results showed that NDFS and OS after SRT were influenced by various factors, including the number of treatments, patient condition, salvage WBRT, and metastasis velocity.
Article
Oncology
Cedric Peters, Julie Vandewiele, Yolande Lievens, Marc van Eijkeren, Valerie Fonteyne, Tom Boterberg, Pieter Deseyne, Liv Veldeman, Wilfried De Neve, Chris Monten, Sabine Braems, Frederic Duprez, Katrien Vandecasteele, Piet Ost
Summary: This study evaluated the adoption of single-fraction radiotherapy (SFRT) and multiple-fraction radiotherapy (MFRT) for uncomplicated painful bone metastases, showing that adherence to the international guidelines for SFRT was high and increased over time to 95%.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2021)
Article
Oncology
Kei Ito, Kentaro Taguchi, Yujiro Nakajima, Hiroaki Ogawa, Keiko Nemoto Murofushi
Summary: This study used propensity score-matched analysis to compare the pain palliation effect of stereotactic body radiotherapy (SBRT) and conventional external beam radiotherapy (cEBRT) for non-spine bone metastases. The results showed that SBRT had a significantly higher pain response rate at 3 months compared to cEBRT. This suggests that large-scale randomized controlled trials are needed to further evaluate the effectiveness of SBRT and cEBRT for painful bone metastases not involving the spine.
Review
Biochemistry & Molecular Biology
Miriam Tomaciello, Miriam Conte, Francesca Romana Montinaro, Arianna Sabatini, Giorgia Cunicella, Federico Di Giammarco, Paolo Tini, Giovanni Luca Gravina, Enrico Cortesi, Giuseppe Minniti, Giuseppe De Vincentis, Viviana Frantellizzi, Francesco Marampon
Summary: The abscopal effect (AE) refers to the ability of radiotherapy (RT) to induce immune-mediated responses in nonirradiated distant metastases. Bone metastases (BMs) are common and provide an immunologically favorable environment for cancer cell proliferation. This study reviewed the literature and evaluated the incidence of AE involving BMs in patients receiving palliative RT.
Article
Oncology
Michael Brada, Helen Forbes, Susan Ashley, John Fenwick
Summary: Big data analysis of a national cohort of patients with NSCLC treated in England suggests that a 6-week regimen of conventional fractionation to a dose of 60 to 66 Gy at 2 Gy per fraction is associated with a survival benefit compared to a 4-week regimen of 55 Gy in 20 fractions.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Review
Health Care Sciences & Services
Eva Oldenburger, Maaike L. De Roo
Summary: This review examines recent literature on the causes, identification, consequences, and interventions to reduce burnout in the professional palliative healthcare provider setting. Research primarily focuses on gaining further insight into the various factors contributing to burnout at individual, social, and organizational levels, with limited studies on prevention interventions. While the results of interventions show promise, data on their long-term effects and impact on healthcare provider retention are lacking. Further research on prevention and treatment of burnout is necessary.
CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE
(2023)
Article
Oncology
Lien Smets, Annelies Debucquoy, Eva Oldenburger, Chantal Van Audenhove, Lynn Debrun, Jeroen Dekervel, Gabriele Bislenghi, Andre D'Hoore, Albert Wolthuis, Karin Haustermans
Summary: This study developed a patient decision aid (PtDA) for rectal cancer patients with a clinical complete response after neo-adjuvant treatment, aiming to facilitate shared decision making. The results of the survey showed that most patients believed using a PtDA in clinical practice would be of added value in decision making.
Article
Oncology
Sebastian M. Christ, Philip Heesen, Urs J. Muehlematter, Kaspar Pohl, Gabriel William Thiel, Jonas Willmann, Maiwand Ahmadsei, Tiuri E. Kroese, Michael Mayinger, Panagiotis Balermpas, Andreas Wicki, Nicolaus Andratschke, Martin Huellner, Matthias Guckenberger
Summary: This study aimed to analyze the recognition of and treatment recommendations for oligometastatic patients by multidisciplinary tumor boards (MDTs) in order to better understand current treatment patterns. The results showed that more than half of oligometastatic cases were discussed in MDTs, and the majority received a recommendation including the addition of local therapy. This highlights the importance of multidisciplinary decision-making and the need for standardization in MDT discussions.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Nynke Willers, Patrick Neven, Giuseppe Floris, Cecile Colpaert, Eva Oldenburger, Sileny Han, Chantal Van Ongeval, Ann Smeets, Francois P. Duhoux, Hans Wildiers, Petra Denolf, Nele Laudus, Els Dequeker, Isabel De Brabander, Nancy Van Damme, Harlinde De Schutter
Summary: Current management of B3 lesions typically involves wide excision, although surveillance may be sufficient for some patients. This study investigates the upgrade risk of B3 lesions diagnosed on core needle biopsy (CNB) or vacuum assisted biopsy (VAB), which is comparable to international literature except for flat epithelial atypia diagnosed on CNB. Based on the observed upgrade rate, a guideline applicable for the Belgian population is proposed.
CLINICAL BREAST CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pavel Nikulin, Sebastian Zschaeck, Jens Maus, Paulina Cegla, Elia Lombardo, Christian Furth, Joanna Kazmierska, Julian M. M. Rogasch, Adrien Holzgreve, Nathalie L. Albert, Konstantinos Ferentinos, Iosif Strouthos, Marina Hajiyianni, Sebastian N. Marschner, Claus Belka, Guillaume Landry, Witold Cholewinski, Joerg Kotzerke, Frank Hofheinz, Joerg van den Hoff
Summary: We developed an automated tool using a neural network for the delineation and classification of metabolic tumor volume (MTV) in head and neck cancer patients. The network performed well in segmenting and classifying primary tumors and lymph node metastases, which can greatly facilitate data evaluation and potentially be applied in clinical settings.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Health Care Sciences & Services
Eva Oldenburger, Julie Devlies, Dylan Callens, Maaike L. L. De Roo
Summary: Proxy-reported outcomes are sometimes used as a substitute for patient-reported outcomes in palliative care due to the difficulty in retrieving patient-reported outcomes. However, recent findings suggest that there are factors influencing the discrepancy between patients' and proxies' reports. Proxy-reported outcomes should be used with caution and considered as a complementary perspective rather than a true substitute for the individual patient's outcome.
CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE
(2023)
Article
Oncology
Ishan Mehta, Alimu Dayimu, Satish Kumar, Clare Boobier, Olabode Oladipo, David Burke, Anna Olson-Brown, Pembe Yesildag, Jenny Nobes, Stephanie Brown, Catherine Booth, Matthew Wheater, Daniel Muller, Vanessa Fountain, Lucy Ford, Ruth Board, Luke McGurk, Sophie Twelves, Nikos Demiris, Pippa Corrie
Summary: This study retrospectively reviewed the prescribing of pembrolizumab for melanoma patients in multiple UK centers. The study found that the toxicity outcomes and efficacy were similar between Q6W and Q3W. Preexisting autoimmune comorbidity and treatment for advanced disease were factors associated with a higher likelihood of receiving Q3W.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Jonas Willmann, Selma Adilovic, Eugenia Vlaskou Badra, Sebastian M. Christ, Maiwand Ahmadsei, Stephanie Tanadini-Lang, Michael Mayinger, Matthias Guckenberger, Nicolaus Andratschke
Summary: This study compared the characteristics and outcomes of patients with oligometastatic disease (OMD) treated with a single course and repeat stereotactic body radiotherapy (SBRT). The results showed that although patients treated with repeat SBRT had shorter progression-free survival (PFS), they had longer overall survival (OS). Therefore, the role of repeat SBRT for OMD patients deserves further investigation.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Maiwand Ahmadsei, Sebastian M. Christ, Tiuri E. Kroese, Anja Kuhnis, Jonas Willmann, Panagiotis Balermpas, Nicolaus Andratschke, Stephanie Tanadini-Lang, Matthias Guckenberger
Summary: This study analyzed the safety and efficacy profile of radiotherapy in patients treated with multiple repeat courses of irradiation. The results showed that multiple courses of repeat radiotherapy maintain a favorable therapeutic ratio of high response combined with reasonable safety profile. Increasing numbers of radiotherapy courses, type 1 reirradiation, and poor overall health status were associated with worse treatment responses.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Meeting Abstract
Oncology
Charlotte Berteloot, Patrick Neven, Maja Vangoitsenhoven, Annouschka Laenen, Hans Wildiers, Kevin Punie, Ann Smeets, Ines Nevelsteen, Sileny Han, Thais Baert, Hilde Janssen, Eva Oldenburger, Adinda Baten, Patrick Berteloot, Rani Vanhoudt, Anne Deblander, Chantal Remmeriev, Christine Desmedt
Article
Oncology
Michal Kazmierski, Mattea Welch, Sejin Kim, Chris McIntosh, Katrina Rey-McIntyre, Shao Hui Huang, Tirth Patel, Tony Tadic, Michael Milosevic, Fei-Fei Liu, Adam Ryczkowski, Joanna Kazmierska, Zezhong Ye, Deborah Plana, Hugo J. W. L. Aerts, Benjamin H. Kann, Scott V. Bratman, Andrew J. Hope, Benjamin Haibe-Kains
Summary: Artificial intelligence and machine learning are critical in personalized medicine and clinical trials. We developed machine learning models to predict overall survival in head and neck cancer using electronic medical records and imaging data. The model with the highest accuracy used multitask learning on clinical data and tumor volume.
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Jonas Willmann, L. Appelt, Panagiotis Balermpas, G. Baumert, Dirk de Ruysscher, Morten Hoyer, Coen Hurkmans, Orit Kaidar-Person, Icro Meattini, Maximilian Niyazi, Philip Poortmans, Nick Reynaert, Stephanie Tandini-Lang, Yvette van der Linden, Carsten Nieder, Nicolaus Andratschke
Summary: This study investigated the patterns of care for re-irradiation internationally and found significant heterogeneity across anatomical regions, highlighting the need for high-quality evidence from prospective studies to guide treatment decisions and establish safe cumulative dose constraints.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Marcin Miszczyk, Agata Suleja, Szymon Sobel, Maria Stec, Artur Jan Chyrek, Miroslaw Kolbusz, Mateusz Spalek, Aleksandra Nasiek, Magdalena Stankiewicz, Piotr Lelek, Matthias Moll, Adam Kluska, Damian Kazalski, Piotr Saniewski, Konrad Kaminiow, Wojciech Maria Burchardt, Piotr Wojcieszek, Adam Chichel, Piotr Cichone, Tomasz Krzysztofiakf
Summary: A multicentre real-world study on radical salvage re-irradiation for non-melanoma skin cancer (nMSC) recurrences showed that the treatment is associated with high recurrence rates, and the size of the treated lesion is a significant prognostic factor.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Sebastian M. Christ, Kim Borsky, Johannes Kraft, Simon Frei, Jonas Willmann, Maiwand Ahmadsei, Corinna Kirchner, Luisa Sabrina Stark Schneebeli, Federico Camilli, Stephanie Tanadini-Lang, Rifaquat Rahman, Ayal A. Aizer, Matthias Guckenberger, Nicolaus Andratschke, Michael Mayinger
Summary: This study externally validated cBMV and iBMV as prognostic scores for overall survival in patients with brain metastases treated with SRT, while validation of vBMV was not achieved.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Henry C. Y. Wong, Shing Fung Lee, Adrian Wai Chan, Saverio Caini, Peter Hoskin, Charles B. Simone Ii, Peter Johnstone, Yvette van der Linden, Joanne M. van der Velden, Emily Martin, Sara Alcorn, Candice Johnstone, Gustavo Nader Marta, Eva Oldenburger, Srinivas Raman, Agata Rembielak, Vassilios Vassiliou, Pierluigi Bonomo, Quynh-Nhu Nguyen, Edward Chow, Samuel Ryu
Summary: This study compared the efficacy of SBRT and cEBRT in treating spinal metastases through a systematic review and meta-analysis of randomized controlled trials. The results showed that SBRT may provide better complete pain response compared to cEBRT. However, there were no significant differences in overall pain response, local progression, and overall survival between the two treatments. Adverse events were similar, except for a lower incidence of radiation dermatitis in the SBRT group.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)