PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-Dependent Induction of Polo-Like Kinase 4

(2021) Karuna Mittal et al.   MOLECULAR CANCER RESEARCH

Analysis of the “centrosome-ome” identifies MCPH1 deletion as a cause of centrosome amplification in human cancer

(2020) Ryan A. Denu et al.   Scientific Reports

Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131)

(2019) Ryan A. Denu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for polo-like kinase 4 in mediation of cytokinesis

(2019) Michael F. Press et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Senescence and the Immune System in Cancer

(2019) Luis I. Prieto et al.   GERONTOLOGY

4′‐Bromo‐resveratrol, a dual Sirtuin‐1 and Sirtuin‐3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming

(2019) Jasmine George et al.   MOLECULAR CARCINOGENESIS

Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma

(2018) Ryan A. Denu et al.   MOLECULAR CANCER RESEARCH

Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway

(2018) Xiangdong Tian et al.   Cell Death & Disease

Analysis of centrosome and DNA damage response in PLK4 associated Seckel syndrome

(2017) Tuba Dinçer et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumors

(2017) Angela Ogden et al.   Scientific Reports

Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer

(2016) Ryan A. Denu et al.   BMC CANCER

Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton

(2016) Karineh Kazazian et al.   CANCER RESEARCH

A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

(2016) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

(2016) Franz Meitinger et al.   JOURNAL OF CELL BIOLOGY

Analysis of Zinc-Exporters Expression in Prostate Cancer

(2016) Chandra K. Singh et al.   Scientific Reports

53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

(2016) Chii Shyang Fong et al.   eLife

Expression of Polo-Like Kinase 4(PLK4) in Breast Cancer and Its Response to Taxane-Based Neoadjuvant Chemotherapy

(2016) Zhenhua Li et al.   Journal of Cancer

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer

(2015) KAZUYA SHINMURA et al.   ONCOLOGY REPORTS

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

Rampant centrosome amplification underlies more aggressive disease course of triple negative breast cancers

(2015) Vaishali Pannu et al.   Oncotarget

CAND1 Promotes PLK4-Mediated Centriole Overduplication and Is Frequently Disrupted in Prostate Cancer

(2015) Nina Korzeniewski et al.   NEOPLASIA

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance

(2014) Mihaela Marina   Frontiers in Bioscience-Landmark

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

A novel role for Plk4 in regulating cell spreading and motility

(2014) C O Rosario et al.   ONCOGENE

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Loss of centrioles causes chromosomal instability in vertebrate somatic cells

(2013) Joo-Hee Sir et al.   JOURNAL OF CELL BIOLOGY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis

(2012) Andrew J. Holland et al.   MOLECULAR BIOLOGY OF THE CELL

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

(2011) Chieh-Ju C Tang et al.   EMBO JOURNAL

PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update

(2011) X. Wang et al.   NUCLEIC ACIDS RESEARCH

Control of daughter centriole formation by the pericentriolar material

(2008) Jadranka Loncarek et al.   NATURE CELL BIOLOGY