Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors

(2018) Satarupa Sengupta et al.   MOLECULAR CANCER THERAPEUTICS

Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance

(2018) Ilgen Mender et al.   NEOPLASIA

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

(2017) Kareen Bartsch et al.   HUMAN MOLECULAR GENETICS

Cancer biology: Genome jail-break triggers lockdown

(2017) Neil T. Umbreit et al.   NATURE

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway

(2017) Yi-An Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A method for measuring the distribution of the shortest telomeres in cells and tissues

(2017) Tsung-Po Lai et al.   Nature Communications

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

(2017) Jessica Vincent et al.   Nature Communications

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway

(2017) Yi-An Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production

(2016) David Millrine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death

(2015) Luxi Sun et al.   NUCLEIC ACIDS RESEARCH

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

DNA Damage to a Single Chromosome End Delays Anaphase Onset

(2014) Bárbara Alcaraz Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Induction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2′-Deoxyguanosine

(2014) Ilgen Mender et al.   Cancer Discovery

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

(2014) Xu Zhang et al.   Cell Reports

Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress

(2014) Fengtao Su et al.   Cell Reports

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

cGAS Dimerization Entangles DNA Recognition

(2013) Philip J. Kranzusch et al.   IMMUNITY

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

(2013) Philip J. Kranzusch et al.   Cell Reports

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair

(2011) Douglas Miller et al.   DNA REPAIR

Unrepaired clustered DNA lesions induce chromosome breakage in human cells

(2011) A. Asaithamby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Give me a break: How telomeres suppress the DNA damage response

(2009) Eros Lazzerini Denchi   DNA REPAIR

SASPense and DDRama in cancer and ageing

(2009) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Cellular responses to DNA double-strand breaks after low-dose γ-irradiation

(2009) Aroumougame Asaithamby et al.   NUCLEIC ACIDS RESEARCH

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL