LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells

Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity

(2020) Juan Tur et al.   Cell Reports

Mitofusin1 in oocyte is essential for female fertility

(2019) Xiaojing Hou et al.   Redox Biology

Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury

(2019) Wenjun Xiong et al.   Frontiers in Physiology

Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging

(2019) Man Zhang et al.   Aging-US

Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway

(2019) Zhi-li Jia et al.   CHEMOSPHERE

E2F1 activates MFN2 expression by binding to the promoter and decreases mitochondrial fission and mitophagy in HeLa cells

(2019) Sudha Bucha et al.   FEBS Journal

Melatonin maintains mitochondrial membrane potential and decreases excessive intracellular Ca2+ levels in immature human oocytes

(2019) Ya-Jing Liu et al.   LIFE SCIENCES

Mitochondrial division, fusion and degradation

(2019) Daisuke Murata et al.   JOURNAL OF BIOCHEMISTRY

Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos

(2018) Tianren Wang et al.   AGING CELL

Natural history of ovarian function including assessment of ovarian reserve and premature ovarian failure

(2018) Raelia Lew   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Mitochondrial dynamics: overview of molecular mechanisms

(2018) Lisa Tilokani et al.   Essays in Biochemistry

Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

(2018) Nadee Nissanka et al.   FEBS LETTERS

Mitochondrial dynamics: Biological roles, molecular machinery, and related diseases

(2018) Ayman W. El-Hattab et al.   MOLECULAR GENETICS AND METABOLISM

Low MFN2 expression related to ageing in granulosa cells is associated with assisted reproductive technology outcome

(2018) Lingjuan Wang et al.   REPRODUCTIVE BIOMEDICINE ONLINE

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ESHRE Guideline: management of women with premature ovarian insufficiency

(2016)   HUMAN REPRODUCTION

Ovarian ageing: the role of mitochondria in oocytes and follicles

(2016) Pascale May-Panloup et al.   HUMAN REPRODUCTION UPDATE

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

A human leucyl-tRNA synthetase as an anticancer target

(2015) Dawei Li et al.   OncoTargets and Therapy

Are there roles for brain cell senescence in aging and neurodegenerative disorders?

(2014) Florence C. C. Tan et al.   BIOGERONTOLOGY

Mitochondrial dynamics controlled by mitofusins define organelle positioning and movement during mouse oocyte maturation

(2014) Takuya Wakai et al.   MOLECULAR HUMAN REPRODUCTION

Mutations in LARS2, Encoding Mitochondrial Leucyl-tRNA Synthetase, Lead to Premature Ovarian Failure and Hearing Loss in Perrault Syndrome

(2013) Sarah B. Pierce et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The role of Akt signalling in the mammalian ovary

(2013) Sandra Cecconi et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of Mitochondrial Fission and Fusion

(2013) A. M. van der Bliek et al.   Cold Spring Harbor Perspectives in Biology

Chromosomal abnormalities & oxidative stress in women with premature ovarian failure (POF)

(2012) Rima Dada et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Follicular Growth and Atresia in Mammalian Ovaries: Regulation by Survival and Death of Granulosa Cells

(2012) Fuko MATSUDA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Blood Cell Mitochondrial DNA Content and Premature Ovarian Aging

(2012) Marco Bonomi et al.   PLoS One

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of LARS2, located at the commonly deleted region 3p21.3, by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma

(2010) W. Zhou et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Oxidative stress and ATPase6 mutation is associated with primary ovarian insufficiency

(2010) S. Venkatesh et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Primary ovarian insufficiency

(2010) Michel De Vos et al.   LANCET

MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility

(2009) H.-Y. Fan et al.   SCIENCE

ERK activation is regulated by E2F1 and is essential for E2F1-induced S phase entry

(2008) Katya Korotayev et al.   CELLULAR SIGNALLING

Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis

(2008) Seung-Hun Shin et al.   EXPERIMENTAL AND MOLECULAR MEDICINE