Role of synovial lymphatic function in osteoarthritis

Effect of Human Synovial Fluid From Osteoarthritis Patients and Healthy Individuals On Lymphatic Contractile Activity

(2022) Eleftheria Michalaki et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

(2020) Eric Song et al.   NATURE

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

(2020) Stefano Alivernini et al.   NATURE MEDICINE

Biological functions of lymphatic vessels

(2020) Tatiana V. Petrova et al.   SCIENCE

IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

(2020) Heather J. Faust et al.   JOURNAL OF CLINICAL INVESTIGATION

Lineage tracing reveals evidence of a popliteal lymphatic muscle progenitor cell that is distinct from skeletal and vascular muscle progenitors

(2020) H. Mark Kenney et al.   Scientific Reports

Endothelin-1 inhibits size dependent lymphatic clearance of PEG-based conjugates after intra-articular injection into the rat knee

(2019) Thanh N. Doan et al.   Acta Biomaterialia

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Vascular endothelial growth factor signaling in development and disease

(2018) Sinem Karaman et al.   DEVELOPMENT

Inducible nitric oxide synthase as a target for osteoarthritis treatment

(2018) Andreas Leonidou et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Gene Delivery to Joints by Intra-Articular Injection

(2018) Christopher H. Evans et al.   HUMAN GENE THERAPY

Intra-articular clearance of labeled dextrans from naive and arthritic rat knee joints

(2018) Timothy K. Mwangi et al.   JOURNAL OF CONTROLLED RELEASE

Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis

(2018) Echoe M. Bouta et al.   Nature Reviews Rheumatology

Gender-related differences observed among immune cells in synovial fluid in knee osteoarthritis

(2018) E. Kriegova et al.   OSTEOARTHRITIS AND CARTILAGE

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

(2018) William Stephenson et al.   Nature Communications

Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

(2018) Hwee Ying Lim et al.   IMMUNITY

Antioxidant Properties of Ferulic Acid and Its Possible Application

(2018) Kamila Zduńska et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Bortezomib Attenuates Joint Tissue Damage in a Mouse Model of Experimental Post-Traumatic Osteoarthritis, which is Associated with Improved Synovial Lymphatic Function

(2018) Wensheng Wang et al.   Arthritis & Rheumatology

Lymphangiogenesis guidance by paracrine and pericellular factors

(2017) Kari Vaahtomeri et al.   GENES & DEVELOPMENT

Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function

(2016) Yan Chen et al.   Evidence-based Complementary and Alternative Medicine

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis

(2016) Chandran S. Abhinand et al.   Journal of Cell Communication and Signaling

Lymphatic vessel development: fluid flow and valve-forming cells

(2015) Tsutomu Kume   JOURNAL OF CLINICAL INVESTIGATION

Soluble Macrophage Biomarkers Indicate Inflammatory Phenotypes in Patients With Knee Osteoarthritis

(2015) Hikmat N. Daghestani et al.   Arthritis & Rheumatology

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation

(2014) Michael Jeltsch et al.   CIRCULATION

A Normative Study of the Synovial Fluid Proteome from Healthy Porcine Knee Joints

(2014) Tue Bennike et al.   JOURNAL OF PROTEOME RESEARCH

Upregulation of miR-23b Enhances the Autologous Therapeutic Potential for Degenerative Arthritis by Targeting PRKACB in Synovial Fluid-Derived Mesenchymal Stem Cells from Patients

(2014) Onju Ham et al.   MOLECULES AND CELLS

Randomized Trial Investigating the Efficacy of Manual Lymphatic Drainage to Improve Early Outcome After Total Knee Arthroplasty

(2013) Jay R. Ebert et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Distribution and Alteration of Lymphatic Vessels in Knee Joints of Normal and Osteoarthritic Mice

(2013) Jixiang Shi et al.   Arthritis & Rheumatology

A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee

(2012) Marie-Pierre Hellio le Graverand et al.   ANNALS OF THE RHEUMATIC DISEASES

Lymphatic vessels in osteoarthritic human knees

(2012) D.A. Walsh et al.   OSTEOARTHRITIS AND CARTILAGE

Vascular Endothelial Growth Factor Receptor-3 Directly Interacts with Phosphatidylinositol 3-Kinase to Regulate Lymphangiogenesis

(2012) Sanja Coso et al.   PLoS One

Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice

(2011) Quan Zhou et al.   ARTHRITIS AND RHEUMATISM

Therapeutic lymphangiogenesis using stem cell and VEGF-C hydrogel

(2011) Ji Hye Hwang et al.   BIOMATERIALS

T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ

(2011) P.-C. Shen et al.   OSTEOARTHRITIS AND CARTILAGE

Impaired lymphatic contraction associated with immunosuppression

(2011) S. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis

(2009) Ruolin Guo et al.   ARTHRITIS AND RHEUMATISM

Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution

(2009) R. P. Kataru et al.   BLOOD

Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans

(2009) Marielle Alders et al.   NATURE GENETICS

Cell Traffic and the Lymphatic Endothelium

(2008) Louise A. Johnson et al.   Annals of the New York Academy of Sciences

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

(2008) Tuomas Tammela et al.   NATURE