Sirt6 regulates autophagy in AGE-treated endothelial cells via KLF4

Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis

(2020) Linyuan Peng et al.   NUCLEIC ACIDS RESEARCH

Risk of all-cause and CHD mortality in women versus men with type 2 diabetes: a systematic review and meta-analysis

(2019) Guodong Xu et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice

(2019) Hyeong Geug Kim et al.   JOURNAL OF HEPATOLOGY

SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity

(2019) Venkatraman Ravi et al.   NUCLEIC ACIDS RESEARCH

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection

(2018) Nunzia D'Onofrio et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs

(2018) Yiji Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-dependent regulation of KLF4 by glucose in vascular smooth muscle

(2018) Tran T. Hien et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

(2018) Jian Chen et al.   Cell Death & Disease

mTOR Inhibition & Cardiovascular Diseases

(2017) Ammar Kurdi et al.   TRANSPLANTATION

A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction

(2017) Paishiun N. Hsieh et al.   Nature Communications

Sirt6 mRNA-incorporated endothelial microparticles (EMPs) attenuates DM patient-derived EMP-induced endothelial dysfunction

(2017) Tong Jing et al.   Oncotarget

Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling

(2016) Jessica L. Fetterman et al.   ATHEROSCLEROSIS

Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes

(2016) Manasi S. Shah et al.   CIRCULATION RESEARCH

Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice

(2016) Zhiping Liu et al.   Translational Research

SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy

(2016) Jing Lu et al.   Translational Research

Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy

(2015) Zoltán V. Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirtuin 6 protects the heart from hypoxic damage

(2015) Anna Maksin-Matveev et al.   EXPERIMENTAL CELL RESEARCH

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis

(2015) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired autophagy in mouse embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation

(2015) Changchang Liu et al.   Molecular Cancer

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models

(2015) Irene Riz et al.   Oncotarget

Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

(2015) Jason G. Anderson et al.   Molecular Metabolism

Sirtuin 6 Expression and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Incretin Treatment

(2014) Maria Luisa Balestrieri et al.   DIABETES

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis

(2014) Ismail Sergin et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling inSirt6Mutant Mice

(2012) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

SIRT6 in DNA repair, metabolism and ageing

(2010) D. B. Lombard et al.   JOURNAL OF INTERNAL MEDICINE

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE