Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing

(2019) Jean-Pierre Etchegaray et al.   MOLECULAR CELL

SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity

(2019) Venkatraman Ravi et al.   NUCLEIC ACIDS RESEARCH

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality

(2018) Christina M. Ferrer et al.   GENES & DEVELOPMENT

SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity

(2018) Shigeru Suzuki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

(2018) Minxian Qian et al.   eLife

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

(2017) Loren M. Lasko et al.   NATURE

SIRT6: Novel Mechanisms and Links to Aging and Disease

(2017) Luisa Tasselli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway

(2017) Shudong Wang et al.   Cell Death & Disease

SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3α-dependent antioxidant defense mechanisms

(2016) Xiao-Xiao Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Depletion of Tip60 from In Vivo Cardiomyocytes Increases Myocyte Density, Followed by Cardiac Dysfunction, Myocyte Fallout and Lethality

(2016) Joseph B. Fisher et al.   PLoS One

Exercise during pregnancy decreases doxorubicin-induced cardiotoxic effects on neonatal hearts

(2016) Verônica B. Brito et al.   TOXICOLOGY

SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy

(2016) Jing Lu et al.   Translational Research

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer

(2015) Sita Kugel et al.   Cell Reports

Ageing is a risk factor in imatinib mesylate cardiotoxicity

(2014) Wael Maharsy et al.   EUROPEAN JOURNAL OF HEART FAILURE

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate

(2014) A Aries et al.   Cell Death & Disease

Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis

(2013) Min-Xian Qian et al.   CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

DNA Methylation Restricts Lineage-specific Functions of Transcription Factor Gata4 during Embryonic Stem Cell Differentiation

(2013) Masaaki Oda et al.   PLoS Genetics

H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells

(2012) Krishanpal Karmodiya et al.   BMC GENOMICS

Sirtuin 6 protects cardiomyocytes from hypertrophyin vitrovia inhibition of NF-κB-dependent transcriptional activity

(2012) Shan-Shan Yu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6

(2012) Yi Cai et al.   FEBS LETTERS

Structural Basis for Sirtuin Activity and Inhibition

(2012) Hua Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site

(2011) Massimo Ghizzoni et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart

(2010) Ah-Mee Park et al.   CARDIOVASCULAR RESEARCH

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

SIRT1 Regulates Autoacetylation and Histone Acetyltransferase Activity of TIP60

(2010) Jiadong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional dissection of SIRT6: Identification of domains that regulate histone deacetylase activity and chromatin localization

(2010) Ruth I. Tennen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death

(2009) Satoru Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity

(2008) Thomas G. Fazzio et al.   CELL

A Novel Histone Acetyltransferase Inhibitor Modulating Gcn5 Network: Cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl)hydrazone

(2008) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structures of Multiple GATA Zinc Fingers Bound to DNA Reveal New Insights into DNA Recognition and Self-Association by GATA

(2008) Darren L. Bates et al.   JOURNAL OF MOLECULAR BIOLOGY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE