Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA

Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell

(2021) Lars K. Petersen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Affinity Selections of DNA‐Encoded Chemical Libraries on Carbonic Anhydrase IX‐Expressing Tumor Cells Reveal a Dependence on Ligand Valence

(2021) Sebastian Oehler et al.   CHEMISTRY-A EUROPEAN JOURNAL

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

(2020) Peiyuan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A method for estimating binding affinity from primary DEL selection data

(2020) Qiuxia Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch

(2020) Stephen E. Motika et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

(2020) Pei-Pei Kung et al.   ACS Medicinal Chemistry Letters

PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions

(2020) Herschel Mukherjee et al.   ACS Chemical Biology

Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells

(2020) Yiran Huang et al.   Nature Chemistry

Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2

(2019) Yu Ren et al.   Clinical Epigenetics

Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry

(2019) Litovchick et al.   MOLECULES

Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells

(2019) Bo Cai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploring the Lower Limit of Individual DNA-Encoded Library Molecules in Selection

(2019) Qiuxia Chen et al.   SLAS Discovery

Crowding Shifts the FMN Recognition Mechanism of Riboswitch Aptamer from Conformational Selection to Induced Fit

(2018) Ambadas B. Rode et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SamSelect: a sample sequence selection algorithm for quorum planted motif search on large DNA datasets

(2018) Qiang Yu et al.   BMC BIOINFORMATICS

Principles for targeting RNA with drug-like small molecules

(2018) Katherine Deigan Warner et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

(2018) Hasane Ratni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Automated screening for small organic ligands using DNA-encoded chemical libraries

(2016) Willy Decurtins et al.   Nature Protocols

Selective small-molecule inhibition of an RNA structural element

(2015) John A. Howe et al.   NATURE

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

(2015) James Palacino et al.   Nature Chemical Biology

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor

(2015) Zining Wu et al.   ACS Combinatorial Science

Sequence-based design of bioactive small molecules that target precursor microRNAs

(2014) Sai Pradeep Velagapudi et al.   Nature Chemical Biology

A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication

(2013) Mi-Kyung Lee et al.   CHEMICAL COMMUNICATIONS

RNA structure and dynamics: A base pairing perspective

(2013) Sukanya Halder et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Thermodynamics of Ligand Binding to a Heterogeneous RNA Population in the Malachite Green Aptamer

(2011) Joshua E. Sokoloski et al.   BIOCHEMISTRY

Defining the RNA Internal Loops Preferred by Benzimidazole Derivatives via 2D Combinatorial Screening and Computational Analysis

(2011) Sai Pradeep Velagapudi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-Activity Relationships through Sequencing (StARTS) Defines Optimal and Suboptimal RNA Motif Targets for Small Molecules

(2010) Sai Pradeep Velagapudi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein

(2009) A. Davidson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA